Pengaruh Pemberian Koro Benguk (Mucuna pruriens L) terhadap Kadar Gula Darah Tikus Diabetes Melitus yang Diinduksi Streptozotocin

The Influence of Blowed Coro (Mucuna Pruriens L) on Blood Sugar Levels of Diabetes Mellitus Diabetes Induced by Streptozotocin

Authors

  • Endang Widhiyastuti STIKES Nasional
  • Mastuti Widi Lestari STIKES Nasional

DOI:

https://doi.org/10.33084/bjmlt.v2i2.1386

Keywords:

diabetes mellitus, koro benguk coffee, (Mucuna pruriens L), Streptozotocin, blood sugar

Abstract

Diabetes which is well-known in the community as diabetes in Indonesia is a chronic disease, which occurs when the pancreas does not produce enough insulin or when the body cannot utilize the insulin produced by its own products. The Provision of antioxidants in DM mice can reduce blood sugar levels. One of the herbs that can be used for control and management of blood sugar in diabetes is swollen koro. Koro Benguk (Mucuna pruriens L) is a plant that can be used as an alternative treatment because it contains antioxidants that can maintain health without causing toxic effects. The purpose of this study was to determine whether there is an effect of giving koro benguk coffee (Mucuna pruriens L) on blood sugar levels of Streptozotocin-induced Diabetes Mellitus Rats. This study is an experimental study of Sprague Dawley mice. A total of 35 male wistar rats were divided into 5 groups each: normal control (K1); diabetes control (K2); diabetic rats were given a large coffee extract 0.63 mg / g BW rat (P1); diabetic rats were given a large infusion of coffee koro 1.26 mg / g BW rats (P2). Diabetic rats were given an infusion of coffee koro benguk20,52 mg / g BW rats. Fasting blood glucose (GDP) levels were analyzed weekly for 3 weeks using the GOD-PAP method. The results of the study showed a decrease in blood sugar for 4 times the observation time in almost all treatment groups except the positive control group. The conclusions in this study were the provision of related coffee (Mucuna pruriens L) can reduce fasting blood glucose levels in Sprague Dawley rats with diabetes models significantly compared to controls.

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References

Agbafor,K.N. dan Nwachukwu N. 2011. Phytochemical Analysis and Antioxidant Property of Leaf Extracts of Vitexdoniana and Mucuna pruriens. Research Article. Biochemistry Research International.pp 1-4
Bors, W. C., Michel, K. dan Stettmaier. 2001. Flavonoids and Other Polyphenols. Packer, L.Ed. Academic Press. San Diego.
Guyton, A. C., Hall, J. E. 2014. Buku Ajar Fisiologi Kedokteran. Edisi 12. Jakarta : EGC, 1022
James P, Leu, Joel Zonszein. 2010. Principles of Diabetes Mellitus. New York: Springer Science
Kementerian Kesehatan RI. 2014. Situasi dan Analisis Diabetes. Jakarta: Kementerian Kesehatan RI
Matough, Budin., S.B., Hamid, Z.A., Alwahaibi, N., and Mohamed, J., 2012, The Role of Oxidative Stress and Antioxidants in Diabetic Complications, Sultan Qaboos Univ Med J. 12(1): 5–18.
Miller, A. L. 2002. Antioxidant Flavonoid Structure Function and Clinical Usage. http :// www. Thorne. Com/alt medrev/fulltext/flavonoids 1-2 html. Diunduh tanggal 18 Oktober 2019
Perkumpulan Endokrinologi Indonesia, 2015. Konsensus Pengendalian dan Pencegahan Diabetes Mellitus Tipe 2 di Indonesia. PB. PERKENI. Jakarta
Poitout,V dan Robertson, R. P. 2008. Glucotoxicity: Fuel excess and beta cell dysfunction. Endocrine Reviews 29(3):351-366
Rajeshwar, Y., Kumar, G.P.S., Gupta, M. U. K. dan Mazumber. 2005. Studies on In Vitro Antioxidant Activities of Methanol Extract of Mucuna pruriens (Fabaceae) Seeds. European Bulletin of Drug Research. Vol 13 (1)
Retnaning, C. 2017. Penurunan Kadar Glukosa Pada Tikus Hiperglikemi Dengan Asupan Tempe Koro Benguk (Mucuna pruriens L) Desertasi. Program Studi Teknologi Pangan Fakultas Teknologi Pertanian Unika Soegijapranata
Roy, D. C., Barman, S. K., & Shaik, M. M. 2013. Current updates on Centella asiatica: Phytochemistry, pharmacology and traditional uses. Medicinal Plant Research, 3, (4), 20-36.
Shahidi, F. 1999. Natural Antioxidants. Chemistry, Health Effect, and Applications, hal 235- 73. AOCS Press. Champaign, Illinois
Szkudelski T. 2012. Streptozotocin- nicotinamide-induced diabetes in the rat. Characteristics of the experimental model. Experimetal Biolology and Medicine 237:481-490
World Health Organization. 2011. Diabetes: The Problem and The Solution.

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Published

2020-04-30

How to Cite

Widhiyastuti, E., & Lestari, M. W. (2020). Pengaruh Pemberian Koro Benguk (Mucuna pruriens L) terhadap Kadar Gula Darah Tikus Diabetes Melitus yang Diinduksi Streptozotocin: The Influence of Blowed Coro (Mucuna Pruriens L) on Blood Sugar Levels of Diabetes Mellitus Diabetes Induced by Streptozotocin. Borneo Journal of Medical Laboratory Technology, 2(2), 136–140. https://doi.org/10.33084/bjmlt.v2i2.1386