Review: Effect of Red Cabbage Juice (Brassica oleracea var. Capitata f. Rubra) on SGPT Level

Keywords: DILI, SGPT, Red cabbage, Acetaminophen

Abstract

Red cabbage (Brassica oleracea var. Capitata f. Rubra) is a vegetable widely used in Indonesian cuisine. Red cabbage is rich in anthocyanins to reduce SGPT levels in drug-induced liver injury (DILI). This study aims to determine the effect of red cabbage juice on SGPT levels in acetaminophen-induced liver injury. In this post-test, only the control group study, male Wistar rats (300g), were randomly divided into 5 groups (K1-K2-K3-K4-K5). Acetaminophen was given to induce liver injury in rats. The rats were treated with the cabbage juice  (at the dose of 0.5g/ml or 0.7g/ml or 0.9g/ ml. Data were analyzed using One way ANOVA  and LSD post hoc test. Mean SGPT levels for K1, K2, K3, K4, K5 was 58.43 ± 7.18 UI / L, 71.20 ± 9.13 UI/L, 55.73 ± 9.51 UI / L, 72.80 ± 3.47 UI /L, 72.63 ± 3.01 UI /L, respectively. One way ANOVA resulted in p=0.00 (p <0.05). The post hoc LSD test showed significant differences (P <0.05) between all groups except between groups K1-K3, K2-K4, and K2-K5 (p> 0.05). Red cabbage juice can reduce SGPT in acetaminophen-induced liver injury in rats. The most effective dose was 0.5 g/ml.

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References

Ashurst, V.J., dan Nappe, M.T., 2018, Methanol Toxicity, Stat Pearls Publishing.
Bouayed, J. dan Bohn, T., 2010, Exogenous Antioxidants Double-edged Swords in Cellular Redox State, Health Beneficial Effects at Physiologic Doses Versus Deleterious Effects at High Doses, Oxidative Medicine and Cellular Longevity, 228–237.
Cahaya, N., dan Mutia, R., 2014, Evaluasi Obat-Obatan Berpotensi Hepatotoksik pada Pasien Dengan Gangguan Fungsi Hepar di Ruang Rawat Inap RSUD Ulin Banjarmasin, 16–26.
El-Motaleb el-Mowafy, M.A., 2012, Treatment Effect of Red Cabbage and Cysteine Against Paracetamol Induced, 5852–5859.
Elijah, J. P., Ukegbu, C. Y.,Eze. C., Nkwocha, C. C., Okafor, J. O., Amaechi, O., Nduka, F. O., Ozougwu, V., Eyenike, J. O., Ugochukwu, N. E., 2017, Biochemical Effects of the Aqueous Extract of Hibiscus sabdariffa on Liver Marker and Lipid Profiles in Acetaminophen-challenged Rats, Research Journal of Medical Plant, 49–54.
Iyanda, A. A. dan Adeniyi, F. A. A., 2011, Biochemical and Histologic Presentations of Female Wistar Rats Administered With Different Doses of Paracetamol / Methionine, 151–160.
Kozłowska, A. dan Szostak-węgierek, D., 2014, Flavonoids - Food Sources and Health Benefits, 79–85.
Li, D., Wang, P., Luo, Y., Zhao, M., Chen, F., 2017, Health Benefits of Anthocyanins and Molecular Mechanisms : Update From Recent Decade, Critical Reviews in Food Science and Nutrition, Taylor & Francis, 1729–1741.
Licata, A., Minissale, M.G., Calvaruso, V., Craxl, A., 2017, A Focus on Epidemiology of Drug-Induced Liver Injury : Analysis of A Prospective Cohort, 112–121.
Nielsen, I., Inge, L., Dragsted, L., Ravn-Haren, G., Freese, R., Rasmussen, S., 2003, Absorption and Excretion of Black Currant Anthocyanins in Humans and Watanabe Heritable Hyperlipidemic Rabbits, Journal of agricultural and food chemistry, 51, 2813-2820.
Pandey, K.B. dan Rizvi, S.I., 2009, Plant Polyphenols as Dietary Antioxidants in Human Health and Disease, 270–278.
Suganda, G., 2010, Rosella Hibiscus sabdariffa L. Serial Data Ilmiah Terkini Tumbuhan Obat, Badan Pengawas Obat dan Makanan Deputi Bidang Pengawasan Obat Traditional, Kosmetik dan Produk Komplemen Direktorat Obat Asli Indonesia, 8-9.
Waszkowiak, K. dan Gliszczyńska-Świgło, A., 2016, Binary Ethanol–Water Solvents Affect Phenolic Profile and Antioxidant Capacity of Flaxseed Extracts, European Food Research and Technology, 242(5), 777–786.
Wolkoff, A. W., 2010, Disorders of The Liver and Biliary Tree, Approach to Pthe Patient with Liver Disease, Harrison’s Gastroenterology and Hepatology, Editor Dan L. L dan Anthony, S.F., McGraw-Hill Education dan EGC Medical Publiser, 340-384.
Wulandari, T., 2015, Pengaruh Jus Kubis Merah dalam Menurunkan Kadar Kolestrol dan Berat Badan Tikus Putih, Skripsi, Universitas Sebelas Maret, Surakarta.
Yoon, E., Babar, A., Choudhary, M., Kutner, M., Pyrsopoulus, N., 2016, Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update, Journal of Clinical and Translational Hepatology, 4(2), 131–142.
Zeitschrift, D.L., 2014, Anthocyanin Content and Antioxidant Activity of Various Red Fruit Juices.
Zhang, J.I.E., Wang, Z., Liu, X., 2017, Characterization Of Acylated Anthocyanins In Red Cabbage Via Comprehensive Two-Dimensional High Performance Liquid Chromatography and HPLC-MS, 1–7.
Published
2020-10-31
How to Cite
Wahyuningsih, H., & Aulia, A. P. (2020). Review: Effect of Red Cabbage Juice (Brassica oleracea var. Capitata f. Rubra) on SGPT Level. Borneo Journal of Medical Laboratory Technology, 3(1), 172-177. https://doi.org/10.33084/bjmlt.v3i1.1791