Rasio AST/ALT pada Laki-Laki Pengkonsumsi Alkohol di Jalan Mendawai Kota Palangka Raya
AST/ALT Ratio on Alcohol Consumption Men in Mendawai Street Palangka Raya
Abstract
Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) are enzymes predominantly found in hepatocytes, the increased activity in the serum shows liver damage. The AST / ALT ratio is used as a marker for alcoholic liver disease. This study aims to determine the effects of long-term alcohol consumption on the risk of alcoholic liver disease. This study was a descriptive study, involving 20 alcoholic drinkers aged 25-45 years, had consumed alcohol> 5 years and consumed alcohol every day. Our results showed a significant increase (p <0.05) in AST and ALT values based on age group, duration of consumption and dose. While the ratio of AST / ALT, a significant increase was found in the age group and period. In alcohol drinkers, the AST value is higher than ALT. The AST / ALT ratio for heavy drinkers is 1.64. Conclusion: Alcohol-consuming subjects in our study, especially heavy drinkers, were suspected of having a risk of alcoholic liver disease because most had an AST / ALT ratio > 1,5.
Downloads
References
Botros, M. et al. 2013. The De Ritis Ratio : The Test of Time. Clin Biochem. 34: 117–130.
Dakeishi, M. et al. 2004. Effects of Alcohol Consumption on Hepatocellular Injury in Japanese Men. The Tohoku Journal of Experimental Medicine. 202(1): 31–39.
Dguzeh, U. et al. 2018. Alcoholism: A multi-systemic cellular insult to organs. International Journal of Environmental Research and Public Health. 15(6).
Gao, B. and Bataller, R. 2011. Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets. Gastroenterology. 141(5): 1572–1585
Hardjoeno H. 2003. Interpretasi Hasil Tes Laboratorium Dan Diagnostic. Universitas Hasanudin : Makasar
King, MW. 2017. Ethanol Metabolism. Available at:https://themedicalbiochemistrypage.org/ethanol-metabolism.php diakses pada 15 April 2019
Mcdonald, H. et al. 2013. Comparative performance of biomarkers of alcohol consumption in a population sample of working-aged men in Russia: The Izhevsk Family Study. Addiction. 108(9): 1579–1589
Purbayanti, D., dan Saputra, N. A. R. 2017. Efek Mengkonsumsi Minuman Beralkohol Terhadap Kadar Triglisrida. Jurnal Surya Medika (JSM). 3(1): 75-81
Shreevastva, N. K., Pandeya, A. and Mishra, D. K. 2017. A study of AST : ALT ratio in alcoholic and nonalcoholic liver diseases’, Saudi Journal of Medical and Pharmaceutical Sciences, 49 (29): 1047–1050.
Singal, A. K. et al. 2018. ACG clinical guideline: Alcoholic liver disease. American Journal of Gastroenterology. Nature Publishing Group, 113(2): 175–194
Steiner, J. L. and Lang, C. H. 2017. Alcohol, adipose tissue and lipid dysregulation. Biomolecules.
Thursz, M. et al. 2018. EASL Clinical Practice Guidelines: Management of alcohol-related liver disease. Journal of Hepatology. European Association for the Study of the Liver. 69(1): 154–181.
World Health Organisation and Management of Substance Abuse Team (2018) Global status report on alcohol and health 2018., World Health Organisation. doi: /entity/substance_abuse/publications/global_alcohol_report/en/index.html.
Wu, C.-Y. et al. 2010. Relationship Between Blood Alcohol Concentration and Hepatic Enzymes in an Emergency Department. Tzu Chi Medical Journal. Buddhist Compassion Relief Tzu Chi Foundation. 22(1): 24–28
Xu, Q., Higgins, T. and Cembrowski, G. S. 2015. Limiting the Testing of AST. American Journal of Clinical Pathology. 144(3): 423–426
Copyright (c) 2019 Dwi Purbayanti, Muhammad Rizwan Nafarin
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
All rights reserved. This publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording.
