Formulation of Snail Slime (Achatina Fulica) Anti-Acne Emulgel using Tween 80-Span 80 as Emulsifying and HPMC as Gelling Agent

  • Nur Saadah Daud Politeknik Bina Husada Kendari
  • Achnis Jum Akbar Politeknik Bina Husada Kendari
  • Eny Nurhikma Politeknik Bina Husada Kendari
  • Karmilah Karmilah Politeknik Bina Husada Kendari
Keywords: Snail slime, Emulgel, Tween 80, Span 80, HPMC

Abstract

Acne is the condition of abnormal skin which is indicated by inflammation caused by the bacterial infection of Propionibacterium acnes. The natural one which can be used for the medical treatment of acne is the snail mucus (Achatina fulica). The achasin protein of it has antibacterial activity. That snail mucus was made to the emulgel form. This research has used an experimental method and the emulgel formulation used the various concentration of emulsifying agents and the gelling agent. They were Tween 80 1.76%, 2.44%, 3.12%, Span 80 2.24%, 4.06%, 5.88% and HPMC 3.5%, 4.5%, 5.5%. Other additives were propylene glycol, Methylparaben, Propylparaben, paraffin liquid, menthol, and aquadest. Those formulations were tested in physical evaluation during 4 weeks of storage in room temperature, irritation test, hedonic test, and cycling test. The organoleptic test showed that the emulgel were the milk-white color with a distinctive smell. All emulgel were homogenous, non-irritant, with emulsion type oil in water (o/w). This emulgel also met the normal skin of pH value and spread ability’s range. The emulgel viscosity shift was < 10%, with the viscosity value inversely proportional to spreadability. Formula C with 3.12% of Tween 80, 5.88% of Span 80 and 5.5% of HPMC was claimed as the most stable formula both in room temperature and after cycling test. It was also the most preferred by the panelist.

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Author Biographies

Nur Saadah Daud, Politeknik Bina Husada Kendari

Lecturer of Pharmacy

Politeknik Bina Husada Kendari

Achnis Jum Akbar, Politeknik Bina Husada Kendari

Politeknik Bina Husada Kendari

Eny Nurhikma, Politeknik Bina Husada Kendari

Politeknik Bina Husada Kendari

Karmilah Karmilah, Politeknik Bina Husada Kendari

Politeknik Bina Husada Kendari

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Published
2018-10-10
How to Cite
Daud, N. S., Akbar, A. J., Nurhikma, E., & Karmilah, K. (2018). Formulation of Snail Slime (Achatina Fulica) Anti-Acne Emulgel using Tween 80-Span 80 as Emulsifying and HPMC as Gelling Agent. Borneo Journal of Pharmacy, 1(2), 64-67. https://doi.org/10.33084/bjop.v1i2.369