Borneo Journal of Pharmacy <p style="text-align: justify;"><strong>Title:&nbsp;</strong>Borneo Journal of Pharmacy<br><strong>ISSN: </strong><a href="">2621-4814</a> (Online)<br> <strong>Accreditation: </strong>Immediately propose (as of November 2019)<br> <strong>Subject: </strong>Pharmacy<br> <strong>Frequency: </strong>Semiannual (2 issues per year in May and November)<br><strong>Indexed at: </strong><a href=";search_type=kws&amp;search_field=doi">Dimensions</a>, <a href="">DOAJ</a>,&nbsp;<a href="">Crossref,</a>&nbsp;<a href="">ICI</a>,&nbsp;<a href="">ResearchBib</a>, <a href=";user=R7G787AAAAAJ">Google Scholar,</a> <a href="">Garuda,</a> and more<br> <strong>DOI: </strong><a href="">10.33084/bjop</a><br><strong>Archive preservation: </strong><a href="[]=repoId:IOS6026">Indonesia OneSearch,</a><strong>&nbsp;</strong><a href="">GARUDA Ristekdikti</a><br> <strong>Publisher: </strong><a href="" target="_blank" rel="noopener">Institute for Researches and Community Services</a> <a href="" target="_blank" rel="noopener">Universitas Muhammadiyah Palangkaraya</a><br> <strong>Editor in Chief: </strong><a href="">Mohammad Rizki Fadhil Pratama</a></p> <p style="text-align: justify;"><strong>Borneo Journal of Pharmacy</strong> (<em>Borneo J Pharm</em>, ISSN: <em><a href="">2621-4814</a></em> (online)) is a Scientific Journal managed by&nbsp;<strong><a title="Department of Pharmacy Faculty of Health Science" href="" target="_blank" rel="noopener">Department of Pharmacy Faculty of Health Science</a> <a href="" target="_blank" rel="noopener">Universitas Muhammadiyah Palangkaraya</a></strong>&nbsp;and published twice a year (in <strong>May</strong> and <strong>November)</strong> by <strong><a href="" target="_blank" rel="noopener">Institute for Researches and Community Services</a> <a href="" target="_blank" rel="noopener">Universitas Muhammadiyah Palangkaraya</a></strong>, contains articles of research and critical analysis studies in various topics of pharmaceutical science, including:&nbsp;<strong>Pharmacology-Toxicology</strong>;&nbsp;<strong>Pharmacognosy-Phytochemistry</strong>;&nbsp;<strong>Pharmaceutical</strong>;&nbsp;<strong>Analytical Pharmacy-Medicinal Chemistry</strong>;&nbsp;<strong>Microbiology Pharmacy</strong>;&nbsp;<strong>Natural Product Development</strong>;&nbsp;<strong>Clinical-Community Pharmacy</strong>;&nbsp;<strong>Management Pharmacy</strong>; and other Pharmacy aspects.</p> ​Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya en-US Borneo Journal of Pharmacy 2621-4814 <p style="text-align: justify;">Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.</p> <p style="text-align: justify;">Authors who publish with this journal agree to the following terms:</p> <ol> <li class="show" style="text-align: justify;">Any article on the copyright is retained by the author(s).</li> <li class="show" style="text-align: justify;">The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgement of the work authors and initial publications in this journal.</li> <li class="show" style="text-align: justify;">Authors are able to enter into a separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgement of its initial publication in this journal.</li> <li class="show" style="text-align: justify;">Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.</li> <li class="show" style="text-align: justify;">The article and any associated published material is distributed under the Creative Commons Attribution-ShareAlike 4.0 International License</li> </ol> Cover, Content, and Editorial Note from Borneo J Pharm Vol. 2 No. 1 May 2019 <p style="text-align: justify;">Starting from this edition, Borneo J Pharm makes changes to the template in the article that will be published. The amendment aims to make it easier for readers to observe essential parts of each page of the article.<br>In this edition, we succeeded in obtaining several achievements, including publishing all English-language articles and successfully gaining support from several international reviewers from various countries, such as Brunei Darussalam, Russia, India and Libya. We will ensure this achievement as a start and will continue to improve the quality of Borneo J Pharm in the future.<br>This journal aims to publish high-quality articles dedicated to all aspects of the latest outstanding developments in the field but not limited to Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Clinical-Community Pharmacy, Management Pharmacy, and other Pharmacy aspects. This edition contains six articles consisting of Pharmacology-Toxicology, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, and Management Pharmacy topics.<br>Editorial boards are fully aware that there is still room for improvement in this edition, hence with all humility willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank the University, all editors and reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors of the articles, could re-participate for the success of the publication in the next edition in November 2019.</p> Chief Editor of Borneo J Pharm ##submission.copyrightStatement## 2019-05-13 2019-05-13 2 1 10.33084/bjop.v2i1.726 Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp <p style="text-align: justify;">The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.</p> Wa Ode Sitti Zubaydah Wahyuni Wahyuni Sahidin Sahidin Tian Amalia Halik Rina Andriani Astrid Indalifiany Adryan Fristiohady ##submission.copyrightStatement## 2019-05-04 2019-05-04 2 1 1 9 10.33084/bjop.v2i1.694 Antidiarrheal Activity of Ethanolic Extract of Vernonia amygdalina Del Leaves againts Male Mice Induced by Oleum Ricini <p style="text-align: justify;">Leaves of<em> Vernonia amygdalina </em>Del. is one of the alternative plants that people use as antidiarrheal in Martapura, Banjar. The purpose of research to determine the antidiarrheal activity and the effectiveness of ethanolic extract of leaves against male mice. The negative control was given NaCMC 0.5% orally, positive control was given Loperamide HCl 0.005 mg/20 g orally, and groups of ethanolic extract of leaves were given dosages in 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW orally. After 1 hour of treatment, the groups were induced by Oleum ricini orally and were observed for 4 hours. Based on three parameters were frequency, weight, and consistency of diarrhea. From the results observation of that negative control, positive control, EEDA 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW for diarrhea frequency parameter was 7.4 ± 2.30; 2 ± 1.22; 5.8 ± 3.34; 6.2 ± 4.08; 2.4 ± 1.67; the weight parameter was 1.34 ± 0.43; 0.38 ± 0.29;0.66 ± 0.56; 0.57 ± 0.38; 0.49 ± 0.33 and then consistency of diarrhea with EEDA 400 mg/kg BW improved the consistency at 180 minutes compared to control group at 210 minutes. In conclusion, from all parameters of ethanolic extract of&nbsp;<em>Vernonia amygdalina </em>Del. leaves can give an antidiarrhea effect with optimum dosage is 400 mg/kg BW.</p> Karunita Ika Astuti Lusiana Dwi Wulandari Eka Fitri Susiani ##submission.copyrightStatement## 2019-05-04 2019-05-04 2 1 10 14 10.33084/bjop.v2i1.707 Identification of Chemical Compounds from Karamunting Stem (Rhodomyrtus tomentosa) by Thin Layer Chromatography <p style="text-align: justify;">Karamunting or Kalimantan Grapes (Rhodomyrtus tomentosa) is a medicinal plant from Central Kalimantan that is easily found in shrubs. Based on hereditary experiences of the people of Central Kalimantan, karamunting can be used for the treatment of various diseases, one of which is diabetes. This study aims to identify the chemical compounds contained in the karamunting stem. The method used is thin layer chromatography with eluent n-hexane : ethyl acetate and methanol : chloroform. Besides, a color reaction was carried out to determine the group of compounds contained in the methanol extract of the karamunting stem. The TLC results show better stain separation in eluent n-hexane : ethyl acetate with the formation of four stains. Positive results are indicated by the content of phenol, saponin, flavonoid and terpenoid compounds. The existence of this group of compounds can be a clue to further research on the truth of the efficacy of karamunting.</p> Agustinawati Umaternate ##submission.copyrightStatement## 2019-05-03 2019-05-03 2 1 15 19 10.33084/bjop.v2i1.695 In Silico Study to Assess Antibacterial Activity from Cladophora Sp. on Peptide Deformylase: Molecular Docking Approach <p style="text-align: justify;">Increasing antibiotic-resistant pathogenic bacteria is a severe problem in the world. Therefore, there is a need to identify new drugs from natural products and also new drug targets. Cladophora sp. is a marine organism which is known to have bioactive compounds and a potential antibacterial. On the other hand, Peptide Deformylase (PDf) may prove to be a novel drug target since it is crucial for native peptide functioning in most pathogenic bacteria. This study screens for PDf inhibition activity of compounds from Cladophora sp. using molecular docking approach and screening the binding affinity of bioactive compounds against the peptide receptor PDf using Pyrex Autodock Vina software. Docking results were stored and visualized using Biovia Discovery Studio and PyMOL ligand. Ligands were obtained from previous literature in PubChem, and receptor peptide PDf from pathogenic bacteria: Pseudomonas aeruginosa (PDB ID:1N5N), Escherichia coli (PDB ID:1BSK), Enterococcus faecium (PDB ID:3G6N) and Staphylococcus aureus (PDB ID:1LQW), was obtained from the peptide data bank. The results of this screening show with ligand the highest binding affinity against PDf of P. aeruginosa, E. coli, E. faecium, and S. aureus is stearic acid (-5.9 kcal/mol), eicosapentaenoic acid (-6.6 kcal/mol), stearic acid (-5.8 kcal/mol), and stearic acid (-6.2 kcal/mol) respectively. The binding of natural compounds from Cladophora sp. with PDf models may provide a new drug with a different drug target for antibacterial potential.</p> Yoni Rina Bintari Rio Risandiansyah ##submission.copyrightStatement## 2019-05-04 2019-05-04 2 1 20 23 10.33084/bjop.v2i1.717 Phytochemical Screening of Sunflower Leaf (Helianthus annuus) and Anting-Anting (Acalypha indica Linn) Plant Ethanol Extract <p style="text-align: justify;">Many local plants in Indonesia were used as traditional medicines, such as sunflower (Helianthus annuus) and anting-anting (Acalypha indica Linn) plants. Both of them can be used as an antimalarial, antibacterial, antifungal, analgesic, and antihyperlipidemic. This study aims to provide an overview of the secondary metabolites groups contained in sunflower leaf and anting-anting plants for the testing of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and sesquiterpenoids. This study included the extraction of sunflower leaves and anting-anting plants separately using the maceration method for 24 hours with 80% ethanol solvent. The stirring was aided by a shaker for three hours. Each extract was tested by phytochemicals with reagents. The results of phytochemical tests with reagents showed that 80% ethanol extract of sunflower leaves contained an alkaloid, tannin, steroid, and sesquiterpenoid compounds whereas anting-anting plants contained an alkaloid, flavonoid, and triterpenoid compounds.</p> Khoirul Ngibad ##submission.copyrightStatement## 2019-05-02 2019-05-02 2 1 24 30 10.33084/bjop.v2i1.689 Evaluation of Patient Satisfaction Towards Pharmacy Services at Hospital Outpatient Pharmacies in Padang <p style="text-align: justify;">Patient satisfaction with the quality of pharmaceutical services is an essential indicator in the variety of health services in hospitals. Service quality is said to be enjoyable and satisfying if the services received are by or exceeding expectations. Otherwise, service quality is supposed to be inadequate or unsatisfactory if the service received is lower than expected. This study aims to determine the percentage level of patient satisfaction with pharmacy services at hospital outpatient pharmacies in Padang and to find out the pharmaceutical service system carried out by pharmacists on duty at hospital outpatient pharmacies that were located in Padang.&nbsp; This study used descriptive data collection. Satisfaction was assessed by giving questionnaires to respondents, and then the surveys were analyzed descriptively. Assessment of patient satisfaction was conducted by taking data through a poll of 100 respondents. Satisfaction analysis was carried out using a Likert scale, and then the data was displayed in the cartesian form.</p> Sara Surya Sefrianita Kamal Lusia Eka Putri ##submission.copyrightStatement## 2019-05-02 2019-05-02 2 1 31 34 10.33084/bjop.v2i1.571