2024-03-28T12:42:40Z
https://journal.umpr.ac.id/index.php/bjop/oai
oai:journal.umpr.ac.id:article/236
2019-10-11T09:04:12Z
bjop:Nat-Pro-Dev
"180501 2018 eng "
2621-4814
dc
Uji Daya Hambat Ekstrak Etanol Daun Jerangau Hijau terhadap Staphylococcus aureus
Novaryatiin, Susi
Universitas Muhammadiyah Palangkaraya http://umpalangkaraya.ac.id https://orcid.org/0000-0003-0696-6546
Pratomo, Guntur Satrio
Universitas Muhammadiyah Palangkaraya http://umpalangkaraya.ac.id https://orcid.org/0000-0003-2396-1069
Yunari, Cindia
Universitas Muhammadiyah Palangkaraya http://umpalangkaraya.ac.id
Jerangau Hijau is a medicinal plant believed by the people of Central Kalimantan to have an efficacy of treating fever, postpartum injuries, and anti-inflammatory. Based on previous research, Jerangau Hijau is known to contain chemical compounds namely flavonoids and saponins that have activity as an antibacterial. The purpose of this study was to find out whether the ethanolic extract of Jerangau Hijau leaves able to inhibit the growth of Staphylococcus aureus bacteria and to know the concentration of ethanolic extract of Jerangau Hijau leaves that able to inhibit the growth of Staphylococcus aureus bacteria. This research was conducted using the Kirby-Bauer method with disc paper. The extraction process was carried out by percolation method using 96% ethanol solvent. The results showed that the ethanolic extract of Jerangau Hijau leaves was able to inhibit the growth of Staphylococcus aureus bacteria, at concentrations of 1%, 5%, 10%, and 15% with mean inhibitory zones respectively 22±0.2 mm; 32.3±1.4 mm; 26.5±3.8 mm; and 13.1±3 mm.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2018-05-01 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/236
Borneo Journal of Pharmacy; Vol. 1 No. 1 (2018): Borneo Journal of Pharmacy
eng
Copyright (c) 2018 Susi Novaryatiin, Guntur Satrio Pratomo, Cindia Yunari
oai:journal.umpr.ac.id:article/237
2019-10-11T09:04:09Z
bjop:Nat-Pro-Dev
"180501 2018 eng "
2621-4814
dc
Uji Daya Hambat Ekstrak Etanol Batang Saluang Belum terhadap Bakteri Escherichia coli
Handayani, Rezqi
Universitas Muhammadiyah Palangkaraya http://umpalangkaraya.ac.id https://orcid.org/0000-0002-5628-0940
Qamariah, Nurul
Universitas Muhammadiyah Palangkaraya http://umpalangkaraya.ac.id https://orcid.org/0000-0002-2010-4961
Mardova, Saftaria Ayu
Universitas Muhammadiyah Palangkaraya http://umpalangkaraya.ac.id
Saluang Belum one of the herbal plants that have the benefits as a traditional medicine in Central Kalimantan. People in Central Kalimantan trusted Saluang Belum stem has an empirical benefit as a stamina enhancing agent and as an antioxidant. From previous research, Saluang Belum stem has a secondary metabolite that was saponin and tannin. Of these two secondary metabolites scientifically have pharmacological effects one of which was able to inhibit bacterial growth. To prove it in this research, the inhibitory test of ethanol extract of Saluang Belum stem from the growth of Escherichia coli bacteria. The inhibitory test method used in this study was the diffusion method using a variety of concentrations of 0.5%, 1%, 5%, 10%, and 15%. The result of this research, that there was no inhibition zone on the media used in all concentration. From these results can be concluded Saluang Belum stem ethanol extract unable to inhibit the growth of E. coli bacteria at concentrations of 0.5%, 1%, 5%, 10%, and 15%.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2018-05-01 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/237
Borneo Journal of Pharmacy; Vol. 1 No. 1 (2018): Borneo Journal of Pharmacy
eng
Copyright (c) 2018 Rezqi Handayani, Nurul Qamariah, Saftaria Ayu Mardova
oai:journal.umpr.ac.id:article/368
2019-12-01T13:46:09Z
bjop:Nat-Pro-Dev
"181101 2018 eng "
2621-4814
dc
RETRACTED: Antibacterial Activity Test Combination of Kencur (Kaempferia galanga L) Rhizome and Sapodilla (Manilkara zapota L) Leaf Extract against Escherichia coli
Ilhani, Amanda Fadilah
Poltekkes Kemenkes Medan http://www.poltekkes-medan.ac.id/
Ismedsyah, Ismedsyah
Poltekkes Kemenkes Medan http://www.poltekkes-medan.ac.id/
This article has been retracted as a result of multiple publications from the article by the relevant author. Similar articles can be found at the URL https://ejurnal.stmik-budidarma.ac.id/index.php/pelita/article/view/892
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2018-11-01 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/368
Borneo Journal of Pharmacy; Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy
eng
Copyright (c) 2018 Amanda Fadilah Ilhani, Ismedsyah Ismedsyah
oai:journal.umpr.ac.id:article/370
2019-12-01T13:54:50Z
bjop:Nat-Pro-Dev
"181101 2018 eng "
2621-4814
dc
Uji Aktivitas Antioksidan Ekstrak Etanol Buah dan Biji Buah Kalangkala (Litsea angulata) asal Kalimantan Selatan
Saputri, Revita
Sekolah Tinggi Ilmu Kesehatan Borneo Lestari http://stikesborneolestari.ac.id/ https://orcid.org/0000-0002-0406-1367
Susiani, Eka Fitri
Sekolah Tinggi Ilmu Kesehatan Borneo Lestari http://stikesborneolestari.ac.id/
Free radicals are atoms or molecules, having one or more unpaired electrons. Increased production of free radicals can cause oxidative stress and cause many pathological conditions, e.g. cancers, heart diseases, and other diseases. The antioxidant can inhibit oxidative stress. Kalangkala (Litsea angulata) usually found in the South Kalimantan that can be used as an antioxidant. The study aimed to determine the antioxidant activity of ethanolic extract of Kalangkala fruits and seeds from South Kalimantan. Antioxidant activity was conducted qualitatively and quantitative uses the method DPPH. The result of the antioxidant activity of ethanolic extract of Kalangkala fruits and seeds qualitatively showed the presence of yellow spots on a purple background at Thin Layer Chromatography (TLC). The result of the activity of ethanolic extract of Kalangkala seeds quantitatively obtained IC50 value was 48.78 ppm and activity of ethanolic extract of Kalangkala fruits quantitatively obtained IC50 value was 243.14 ppm. Ethanolic extract of Kalangkala fruits and seeds from South Kalimantan has antioxidant activity.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2018-11-01 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/370
Borneo Journal of Pharmacy; Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy
eng
Copyright (c) 2018 Revita Saputri, Eka Fitri Susiani
oai:journal.umpr.ac.id:article/427
2019-12-01T14:18:27Z
bjop:Nat-Pro-Dev
"181101 2018 eng "
2621-4814
dc
Antibacterial Activity of Ethanolic Extract of Sangkareho (Callicarpa longifolia Lam.) against Staphylococcus epidermidis
Novaryatiin, Susi
Universitas Muhammadiyah Palangkaraya http://umpalangkaraya.ac.id https://orcid.org/0000-0003-0696-6546
Sari, Asma'ul Ayuriska
Universitas Muhammadiyah Palangkaraya http://umpalangkaraya.ac.id/
Mulyani, Evi
Universitas Muhammadiyah Palangkaraya http://umpalangkaraya.ac.id/ https://orcid.org/0000-0002-6533-1260
One of the plants believed as traditional medicine by the Dayak tribes in Central Kalimantan was Sangkareho (Callicarpa longifolia Lam.). This plant was usually used as traditional medicine by society in Puruk Cahu, Murung Raya Regency, Central Kalimantan and empirically believed could cure skin disease such as wound infection. This study was aimed to determine the antibacterial activity of ethanolic extract of Sangkareho (Callicarpa longifolia Lam). Antibacterial activity of ethanolic extract of Sangkareho was performed using disc diffusion technique, with four variations of concentration of 1%, 5%, 10%, and 15%. In this present study showed that ethanolic extract of Sangkareho has antibacterial activity against Staphylococcus epidermidis, wherein the resulting inhibition zone diameter was 7.3±0.8 mm, 8.3±1.2 mm, 10.5±0.5 mm, and 12.2±0.7 mm, respectively. Further research is needed to obtain an antibacterial activity of the fraction of Sangkareho.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2018-11-01 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/427
Borneo Journal of Pharmacy; Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy
eng
Copyright (c) 2018 Susi Novaryatiin, Asma'ul Ayuriska Sari, Evi Mulyani
oai:journal.umpr.ac.id:article/689
2022-11-09T14:16:41Z
bjop:Nat-Pro-Dev
"190531 2019 eng "
2621-4814
dc
Phytochemical Screening of Sunflower Leaf (Helianthus annuus) and Anting-Anting (Acalypha indica Linn) Plant Ethanol Extract
Ngibad, Khoirul
Universitas Maarif Hasyim Latif https://www.umaha.ac.id/en/home/ https://orcid.org/0000-0003-1471-7347
Many local plants in Indonesia were used as traditional medicines, such as sunflower (Helianthus annuus) and anting-anting (Acalypha indica Linn) plants. Both of them can be used as an antimalarial, antibacterial, antifungal, analgesic, and antihyperlipidemic. This study aims to provide an overview of the secondary metabolites groups contained in sunflower leaf and anting-anting plants for the testing of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and sesquiterpenoids. This study included the extraction of sunflower leaves and anting-anting plants separately using the maceration method for 24 hours with 80% ethanol solvent. The stirring was aided by a shaker for three hours. Each extract was tested by phytochemicals with reagents. The results of phytochemical tests with reagents showed that 80% ethanol extract of sunflower leaves contained an alkaloid, tannin, steroid, and sesquiterpenoid compounds whereas anting-anting plants contained an alkaloid, flavonoid, and triterpenoid compounds.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2019-05-31 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/689
Borneo Journal of Pharmacy; Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy
eng
Copyright (c) 2019 Khoirul Ngibad
oai:journal.umpr.ac.id:article/928
2022-11-11T07:46:41Z
bjop:Nat-Pro-Dev
"191130 2019 eng "
2621-4814
dc
Antibacterial Activity Test of Ethanol Extract Pineapple (Ananas comosus (L.) Merr.) Peel against Growth of Propionibacterium acnes
Fitriyanti, Fitriyanti
Sekolah Tinggi Ilmu Kesehatan Borneo Lestari https://stikesborneolestari.ac.id/ https://orcid.org/0000-0002-6183-3132
Hendrawan, Muhammad Nur Rahman
Sekolah Tinggi Ilmu Kesehatan Borneo Lestari https://stikesborneolestari.ac.id/
Astuti, Karunita Ika
Sekolah Tinggi Ilmu Kesehatan Borneo Lestari https://stikesborneolestari.ac.id/
Pineapple peel (Ananas comosus (L.) Merr.) is waste from the pineapple fruit. The purpose of this study was to determine the content of pineapple peel extract and to antibacterial activity in various concentrations effective in inhibiting the growth of Propionibacterium acnes. The pineapple peel extract is made by using the extraction method in the form of maceration. The method used in the inhibitory test using the three replication samples in each treatment group. The sample consisted of 10 treatment groups ie pineapple peel extract concentration 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, 87.5%, and 100%, as well as positive and negative control. The results obtained from pineapple peel screening contain flavonoid and saponin compounds. The data analysis shows that pineapple peel extract concentrations of 50%, 62.5%, 75%, 87.5%, and 100% had inhibitory zones with the medium-strong category while clindamycin as the control has a strong inhibition zone. The conclusion of this research proves that pineapple peel extract has antibacterial power to P. acnes with effective concentration is 100% with the strong category.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2019-11-30 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/928
Borneo Journal of Pharmacy; Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy
eng
Copyright (c) 2019 Fitriyanti Fitriyanti, Muhammad Nur Rahman Hendrawan, Karunita Ika Astuti
oai:journal.umpr.ac.id:article/1070
2022-11-11T07:46:41Z
bjop:Nat-Pro-Dev
"191130 2019 eng "
2621-4814
dc
Antioxidant Activity of Ethanolic Extract from Tandui Leaves (Mangifera rufocostata Kosterm.) by DPPH Radical Scavenging Method
Saputri, Revita
Sekolah Tinggi Ilmu Kesehatan Borneo Lestari https://stikesborneolestari.ac.id/ https://orcid.org/0000-0002-0406-1367
Melati, Tia Mariati Risma
Sekolah Tinggi Ilmu Kesehatan Borneo Lestari https://stikesborneolestari.ac.id/
Fitriyanti, Fitriyanti
Sekolah Tinggi Ilmu Kesehatan Borneo Lestari https://stikesborneolestari.ac.id/ https://orcid.org/0000-0002-6183-3132
Tandui (Mangifera rufocostata Kosterm.) is a typical plant from South Kalimantan which belongs to the genus of Mangifera. Several species of Mangifera are known to have antioxidant activity. This study aimed to determine the antioxidant activity of ethanol extract of Tandui leaves. Tandui leaves that were obtained from the maceration method used 70% ethanol. Antioxidant activity was conducted quantitative using the DPPH (2,2-diphenyl-1-picrylhydrazil) method. The result of the antioxidant activity of Ethanol extract of Tandui leaves quantitatively obtained IC50 value was 60.7042 µg/mL. The ethanol extract of Tandui leaves has strong antioxidant activity
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2019-11-30 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1070
Borneo Journal of Pharmacy; Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy
eng
Copyright (c) 2019 Revita Saputri, Tia Mariati Risma Melati, Fitriyanti Fitriyanti
oai:journal.umpr.ac.id:article/1242
2020-04-15T01:05:28Z
bjop:Nat-Pro-Dev
"200227 2020 eng "
2621-4814
dc
Test on the Antioxidant Activities of Methanol Extract of Bidara Leaves (Ziziphus spina-christi L.) using the DPPH Radical Immersion Method
Pambudi, Dwi Bagus
Universitas Muhammadiyah Pekajangan Pekalongan https://umpp.ac.id/ https://orcid.org/0000-0001-7201-9411
Fajriyah, Nuniek Nizmah
Universitas Muhammadiyah Pekajangan Pekalongan https://umpp.ac.id/
Shalekhah, Vidiah Rizka
Universitas Muhammadiyah Pekajangan Pekalongan https://umpp.ac.id/
Bidara (Ziziphus spina-christi L.) is a tropical tree originating from Sudan in which it is commonly known as "Nebeq" in Saudi Arabia. It is of a bioactive compound - a flavonoid compound, which is the potential to be used as an antioxidant. It is capable of inhibiting any cell damages caused by free radicals. This study aimed to measure the activities of the free radicals in methanol extracts of Z. spina-christi leaves. The process of extracting the Z. spina-christi leaves was carried out through the maceration method using methanol as a solvent. The qualitative analysis of chemical compounds with certain eluents using thin-layer chromatography (TLC) was purposely to determine the groups of active compounds in extracts. The measurement of antioxidant activities was carried out using the 1,1-Diphenyl-2-picryl Hidrazyl (DPPH) immersion method in which absorption was measured at a maximum wavelength of 513 nm. The results showed that the methanol extract of Z. spina-christi leaves had a very weak antioxidant activity with the IC50 value of 466.804 μg/ml. The results of the bioautographic profile showed the presence of flavonoid compounds, phenols, saponins, and tannins.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2020-02-27 00:00:00
Peer-reviewed Article
application/pdf
application/xml
https://journal.umpr.ac.id/index.php/bjop/article/view/1242
Borneo Journal of Pharmacy; Vol. 3 No. 1 (2020): Borneo Journal of Pharmacy
eng
Copyright (c) 2020 Dwi Bagus Pambudi, Nuniek Nizmah Fajriyah, Vidiah Rizka Shalekhah
oai:journal.umpr.ac.id:article/1415
2020-09-04T12:20:36Z
bjop:Nat-Pro-Dev
"200831 2020 eng "
2621-4814
dc
Advantages of Herbal Over Allopathic Medicine in the Management of Kidney and Urinary Stones Disease
Nimesh, Saurabh
Shri Gopichand College of Pharmacy http://shrigopichandpharmacy.org/ https://orcid.org/0000-0002-7138-131X
Ashwlayan, Vrish Dhwaj
Meerut Institute of Engineering and Technology https://www.miet.ac.in/ https://orcid.org/0000-0002-8902-2358
Rani, Rubi
NKBR College of Pharmacy and Research Centre http://www.nkbr.org/ https://orcid.org/0000-0001-8032-8476
Prakash, Om
Shri Gopichand College of Pharmacy http://shrigopichandpharmacy.org/ https://orcid.org/0000-0002-3196-5855
Kidney and urinary stone disease (Nephrolithiasis and urolithiasis) are the condition where urinary stones or calculi are formed in the urinary tract. The problem of urinary stones is very ancient; these stones are found in all parts of the urinary tract, kidney, ureters, and the urinary bladder and may vary considerably in size. It is a common disease estimated to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males and 47-60% in females. The treatment of kidney and urinary stone diseases such as a western (allopathy) medicine and surgery is now in trends. However, most people preferred plant-based (herbal) therapy because of the overuse of allopathic drugs, which results in a higher incidence rate of adverse or severe side effects. Therefore, people every year turn to herbal therapy because they believe plant-based medicine is free from undesirable side effects, although herbal medicines are generally considered to be safe and effective. In the present article, an attempt has been made to emphasize an herbal therapy is better than allopathic therapy for the management of the kidney and urinary stone disease.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2020-08-31 00:00:00
Peer-reviewed Article
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1415
Borneo Journal of Pharmacy; Vol. 3 No. 3 (2020): Borneo Journal of Pharmacy
eng
Copyright (c) 2020 Saurabh Nimesh, Vrish Dhwaj Ashwlayan, Rubi Rani, Om Prakash
oai:journal.umpr.ac.id:article/1500
2020-12-08T00:50:01Z
bjop:Nat-Pro-Dev
"201130 2020 eng "
2621-4814
dc
Determination of Antiradical Activity, Total Phenolic, and Total Flavonoid Contents of Extracts and Fractions of Langsat (Lansium domesticum Coor.) Seeds
Yamin, Yamin
Universitas Halu Oleo http://uho.ac.id https://orcid.org/0000-0001-8509-463X
Ruslin, Ruslin
Universitas Halu Oleo http://uho.ac.id https://orcid.org/0000-0003-1974-5021
Sabarudin, Sabarudin
Universitas Halu Oleo http://uho.ac.id https://orcid.org/0000-0003-3485-2319
Sida, Nurramadhani A
Universitas Halu Oleo http://uho.ac.id https://orcid.org/0000-0002-2731-3977
Kasmawati, Henny
Universitas Halu Oleo http://uho.ac.id https://orcid.org/0000-0002-4355-5933
Diman, La Ode Muhammad
Universitas Halu Oleo http://uho.ac.id
Lansium domesticum Coor. is a fruit species from the Meliaceae family, which is a tropical plant native to Southeast Asia. Local citizens call it langsat, longkong, or duku and have used it as traditional medicine. The seeds of L. domesticum are used as a fever medicine, its bark is used to treat scorpion sting, and its leaves are used to repel mosquitoes. Because of its various uses, it is necessary to explore the antiradical potential of L. domesticum seeds. This study aims to determine the antiradical potential of L. domesticum seeds extract and fractions by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and to discover compounds that act as antiradical. Lansium domesticum seed powder was macerated with methanol, and then the extract was concentrated using a rotary evaporator and fractionated by n-hexane and ethyl acetate. The antiradical assay was conducted on extract and fractions by using DPPH radicals. Phenolic and flavonoid contents from extract and fractions were also tested. The ethyl acetate fraction obtained strong antiradical potential with an IC50 value of 8.938 ± 0.031 µg/mL. Total phenolic and flavonoid contents of ethyl acetate fraction were higher with values of 58.25 ± 0.501 mgGAE/g sample and 75.123 ± 0.175 mgQE/g sample, respectively. Correlation of phenolic and flavonoid contents, which inhibited radicals had R2 values of 0.9182 and 0.7658. Ethyl acetate fraction of L. domesticum seeds had very strong antiradical activity. Further isolation is expected to be conducted to discover which compounds are the most responsible as antiradical.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2020-11-30 12:10:26
Peer-reviewed Article
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1500
Borneo Journal of Pharmacy; Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy
eng
Copyright (c) 2020 Yamin Yamin, Ruslin Ruslin, Sabarudin Sabarudin, Nurramadhani A Sida, Henny Kasmawati, La Ode Muhammad Diman
oai:journal.umpr.ac.id:article/1578
2021-05-20T02:39:24Z
bjop:Nat-Pro-Dev
"210228 2021 eng "
2621-4814
dc
The Combination of Turmeric (Curcuma domestica) Rhizome Extract and Collagen in A Serum Formulation as an Antioxidant
Pratiwi, Denia
Universitas Abdurrab https://univrab.ac.id/ https://orcid.org/0000-0002-6087-2367
Sidoretno, Wahyu Margi
Universitas Abdurrab https://univrab.ac.id/ https://orcid.org/0000-0003-1887-3232
Aisah, Nur
Universitas Abdurrab https://univrab.ac.id/
Turmeric (Curcuma domestica) has nutritious compounds called curcuminoids, which can be used as antioxidants. As an antioxidant, C. domestica extract can be used to ward off free radicals that damage collagen and elastin, a protein that keeps skin moist. This study aimed to determine the antioxidant activity of serum combined with collagen's addition using the DPPH method. The DPPH was made at a concentration of 80 μg/mL, and the absorption was read at a wavelength of 520 nm using a microplate rider. The study was conducted by making six formulations: F0, F1, F2, F3, F4, and F5 obtained the results of serum made from C. domestica extract that could inhibit free radicals and meet the physical evaluation test requirements of serum. Furthermore, the formula was made using only one active ingredient and only collagen to determine the extract or collagen's antioxidant activity. The results obtained indicate that collagen had a supporting role in adding antioxidant activity apart from its extract. The highest % inhibition value at F5 with 90.526% could ward off free radicals.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-02-28 00:00:00
Peer-reviewed Article
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1578
Borneo Journal of Pharmacy; Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy
eng
Copyright (c) 2021 Denia Pratiwi, Wahyu Margi Sidoretno, Nur Aisah
oai:journal.umpr.ac.id:article/1589
2021-05-20T02:39:24Z
bjop:Nat-Pro-Dev
"210228 2021 eng "
2621-4814
dc
Formulation and Antibacterial Activity of Liquid Soap Containing Ketapang (Terminalia catappa L.) Leaves Extract
Dewi, Asiska Permata
Universitas Abdurrab https://univrab.ac.id/
Mardhiyani, Dini
Universitas Abdurrab https://univrab.ac.id/ https://orcid.org/0000-0003-0823-7259
Ketapang (Terminalia catappa L.) is traditionally used by the community to treat the skin's infections caused by bacteria or fungi. In this study, T. catappa leaves extract was added to the liquid soap formula as an antibacterial. The purpose of this study was to determine the secondary metabolite compounds contained in T. catappa leaves extract, physical evaluation of the preparation, and antibacterial activity of liquid soap. Liquid soap formula was made with various concentrations of T. catappa leaves extract F0 (0%), F1 (1%), F2 (2%), and F3 (3%). The resulting soap was evaluated for organoleptic, pH, high foam, homogeneity, irritation, and its activity against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli using the disc diffusion method. The results showed that the T. catappa leaves extract contained flavonoids, tannins, saponins, and triterpenoids. The liquid soap formula F0 was clear, while F1, F2, and F3 had the characteristics of brown-dark brown, homogeneous, pH between 4.6-5.2, foam stability between 67-72%, which was not significantly different and stable after five minutes of testing, and it did not irritate the skin. Terminalia catappa leaves extracts liquid soap has antibacterial activity at a concentration of 1%, 2%, and 3%, with the largest inhibition zone diameter produced by S. aureus.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-02-28 00:00:00
Peer-reviewed Article
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1589
Borneo Journal of Pharmacy; Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy
eng
Copyright (c) 2021 Asiska Permata Dewi, Dini Mardhiyani
oai:journal.umpr.ac.id:article/1644
2020-12-08T00:49:43Z
bjop:Nat-Pro-Dev
"201130 2020 eng "
2621-4814
dc
Potential of Frangipani (Plumeria alba) Leaves Extract as Ultra Violet Protection
Putra, I Gusti Ngurah Agung Windra Wartana
Universitas Bali Internasional http://farmasi.unbi.ac.id/
Arimbawa, Putu Eka
Universitas Bali Internasional http://farmasi.unbi.ac.id/ https://orcid.org/0000-0001-5557-7059
Artini, Ni Putu Rahayu
Universitas Bali Internasional http://farmasi.unbi.ac.id/
Sunlight is the source of life and energy. Besides that, sunlight also creates skin challenges such as sunburn, pigmentation, wrinkles, dermatitis, aging, and skin cancer. Natural sunscreen protection is a popular and preferred way among various regions of the world to reduce sunlight's harmful effect. This study aimed to determine the potential of frangipani (Plumeria alba) leaves extract in some concentrations as ultraviolet protection. Plumeria alba extract contained secondary metabolites such as flavonoids, phenolics, and alkaloids that function as impeding ultraviolet radiation. This study used an experimental method consisting of four treatments and six replications. This study shows that the extract with concentration 2500; 5000; 7500; and 10000 ppm consecutively have SPF value of 6.24; 12.00; 18.45; and 22.64. It can be concluded the P. alba leaves extract potential as ultraviolet protection.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2020-11-30 12:10:26
Peer-reviewed Article
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1644
Borneo Journal of Pharmacy; Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy
eng
Copyright (c) 2020 I Gusti Ngurah Agung Windra Wartana Putra, Putu Eka Arimbawa, Ni Putu Rahayu Artini
oai:journal.umpr.ac.id:article/1817
2021-05-20T02:39:24Z
bjop:Nat-Pro-Dev
"210228 2021 eng "
2621-4814
dc
Formulation, Organoleptic Evaluation, and Acceptability of Various Teas from Underutilized Nutritious Herbs Compared with Marketed Chinese and Yellow Lipton Tea
Ehoche, Elijah Edache
Federal University of Technology Minna https://www.futminna.edu.ng/ https://orcid.org/0000-0002-7821-3220
Patel, Parth
Humera Khan College of Pharmacy https://hkcp.edu.in/site/ https://orcid.org/0000-0002-3694-9213
Madu, Chijioke
University of Abuja https://www.uniabuja.edu.ng/ https://orcid.org/0000-0002-6803-8449
Adejoh, Johnson
University of Abuja https://www.uniabuja.edu.ng/ https://orcid.org/0000-0001-8978-1779
Herbal teas are nutrient, antioxidant, and hydration-rich brews made from herbs and spices and taken for various purposes. The objective of this study was to formulate tea from clove (Syzygium aromaticum), leaves of lemongrass (Cymbopogon citratus), guava (Psidium guajava), and moringa (Moringa oleifera), as well as compared with Chinese and yellow Lipton Tea. The samples were analyzed for comparative sensory analysis using the 7 points hedonic scale. The sensory evaluation result demonstrated that the color of the clove tea sample (5.87) was most acceptable by participants, while the lemongrass tea (4.46) sample was least acceptable amongst all the tea samples. The clove remained the most accepted tea for aroma (6.07), taste (5.92), texture (5.76), general appearance (5.74), and general acceptability (5.93), in 7 points hedonic scale. However, all tea samples were had significant acceptable scores above average (p <0.05). Owing to the above results, these herbs can be successfully used to produce tea of relatively good quality to encourage herbs' local consumption and stay healthy.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-02-28 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/1817
Borneo Journal of Pharmacy; Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy
eng
Copyright (c) 2021 Elijah Edache Ehoche, Parth Patel, Chijioke Madu, Johnson Adejoh
oai:journal.umpr.ac.id:article/1955
2021-09-15T08:41:27Z
bjop:Nat-Pro-Dev
"210830 2021 eng "
2621-4814
dc
In-vitro Cytotoxicity and In-silico Insights of the Multi-target Anticancer Candidates from Haplophyllum tuberculatum
Al-Nour, Mosab Yahya
Omdurman Islamic University http://www.oiu.edu.sd/en/ https://orcid.org/0000-0002-5044-3948
Arbab, Ahmed H
University of Khartoum https://www.uofk.edu/en/ https://orcid.org/0000-0002-5975-112X
Parvez, Mohammad Khalid
King Saud University https://ksu.edu.sa/en/ https://orcid.org/0000-0002-7154-9151
Mohamed, Arwa Y
Omdurman Islamic University http://www.oiu.edu.sd/en/ https://orcid.org/0000-0003-1209-2689
Al-Dosari, Mohammed S
King Saud University https://ksu.edu.sa/en/ https://orcid.org/0000-0001-8980-6606
This study aimed to investigate the anticancer activity of Haplophyllum tuberculatum(Forsk.) aerial parts ethanol extract and fractions and reveal the potential anticancer targets, binding modes, pharmacokinetics, and toxicity properties of its phytoconstituents. MTT assay was used to investigate the anticancer activity. TargetNet, ChemProt version 2.0, and CLC-Pred web servers were used for virtual screening, and Cresset Flare software was used for molecular docking with the 26 predicted targets. Moreover, pkCSM, swiss ADME, and eMolTox web servers were used to predict pharmacokinetics and safety. Ethanolic extracts of H. tuberculatum on HepG2 and HeLa cell lines showed promising activities with IC50 values 54.12 and 48.1 µg/mL, respectively. Further, ethyl acetate fraction showed the highest cytotoxicity on HepG2 and HeLa cell lines with IC50 values 41.7 and 52.31 µg/mL. Of 70 compounds screened virtually, polygamain, justicidin A, justicidin B, haplotubine, kusunokinin, and flindersine were predicted as safe anticancer drugs candidates. They showed the highest binding scores with targets involved in cell growth, proliferation, survival, migration, tumor suppression, induction of apoptosis, metastasis, and drug resistance. Our findings revealed the potency of H. tuberculatum as a source of anticancer candidates that further studies should support.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-08-30 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/1955
Borneo Journal of Pharmacy; Vol. 4 No. 3 (2021): Borneo Journal of Pharmacy
eng
Copyright (c) 2021 Mosab Yahya Al-Nour, Ahmed H Arbab, Mohammad Khalid Parvez, Arwa Y Mohamed, Mohammed S Al-Dosari
oai:journal.umpr.ac.id:article/2154
2021-09-15T08:41:13Z
bjop:Nat-Pro-Dev
"210830 2021 eng "
2621-4814
dc
Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa
Septiana, Eris
Indonesian Institute of Sciences http://lipi.go.id/
Rizka, Nurul Maulida
Universitas Pancasila http://www.univpancasila.ac.id/
Yadi, Yadi
Indonesian Institute of Sciences http://lipi.go.id/
Simanjuntak, Partomuan
Indonesian Institute of Sciences http://lipi.go.id/ https://orcid.org/0000-0002-8501-908X
Traditionally and scientifically, research has shown that Orthosiphon aristatus and Oryza sativa L. var. glutinosa have antidiabetic activity. The combination of two medicinal plants can increase their biological activity. This study aimed to determine the antidiabetic activity of O. aristatus and O. sativa L. var. glutinosa on single and combined extracts. Phytochemical screening of the single extract was done qualitatively. The α-glucosidase inhibitory method was used as an antidiabetic activity. The results showed that every extract contained alkaloids, steroids/triterpenoids, flavonoids, tannins, quinones, and coumarins. A single extract of O. sativa L. var glutinosa, O. aristatus, and their combinations (1:1, 1:2, and 2:1) had an α-glucosidase enzyme inhibitory activity with an IC50 value of 67.82, 80.93, 73.81, 88.72, and 61.51 µg/ml, respectively. The combination shows that the ratio of 1:1 was nearly additive, 1:2 was slight to moderate antagonism, and 2:1 was moderate to slight synergism. The combination of 96% ethanol extract of O. sativa L. var. glutinosa and O. aristatus in a ratio of 2:1 was the most effective in increasing its inhibitory activity.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-08-30 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/2154
Borneo Journal of Pharmacy; Vol. 4 No. 3 (2021): Borneo Journal of Pharmacy
eng
Copyright (c) 2021 Eris Septiana, Nurul Maulida Rizka, Yadi Yadi, Partomuan Simanjuntak
oai:journal.umpr.ac.id:article/2544
2022-02-15T08:20:08Z
bjop:Nat-Pro-Dev
"211130 2021 eng "
2621-4814
dc
Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves
Isaac, Johnson Ajeh
National Institute for Pharmaceutical Research and Development https://www.healthresearchweb.org/en/nigeria/keygroups_4117 https://orcid.org/0000-0003-3931-9521
Ekere, Kokonne Elizabeth
National Institute for Pharmaceutical Research and Development https://www.healthresearchweb.org/en/nigeria/keygroups_4117 https://orcid.org/0000-0001-8876-9284
Ezekiel, Ekeh
National Institute for Pharmaceutical Research and Development https://www.healthresearchweb.org/en/nigeria/keygroups_4117
Galadima, Isa Hayatu
National Institute for Pharmaceutical Research and Development https://www.healthresearchweb.org/en/nigeria/keygroups_4117 https://orcid.org/0000-0002-0750-6288
Abdulahi, Rashida
National Institute for Pharmaceutical Research and Development https://www.healthresearchweb.org/en/nigeria/keygroups_4117
Samali, Ayuba
National Institute for Pharmaceutical Research and Development https://www.healthresearchweb.org/en/nigeria/keygroups_4117 https://orcid.org/0000-0001-7638-8273
Traditionally, the leafy part of Andrographis paniculata and Moringa oleifera have been widely reported to manage hypertension. Investigation of its pharmacological actions justifies its use. As part of formulation studies to standardize them, this study focused on their compaction and compression properties. Compacts equivalent to 250 mg of A. paniculata and M. oleifera were produced by compressing powders and granules at various compression pressure. Results show that M. oleifera met the WHO limit for ash values. Relative density values for granulated batches were higher, while their moisture content values were lower when compared to those of direct compression. The result from Heckel plots shows that batches deform mainly by plastic flow. For Kawakita plots, values of 1/b show that batches containing microcrystalline cellulose were less cohesive. The plot of tensile strength signifies that granulated batches achieved maximum crushing strength faster at low pressure. Formulations containing maize starch were shown to have higher percent porosity, and granulated batches gave higher values for apparent density-pressure relationship and lower friability values. Tablets produced by the wet granulation method showed better compression and compaction properties than those formulated by direct compression.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-11-30 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/2544
Borneo Journal of Pharmacy; Vol. 4 No. 4 (2021): Borneo Journal of Pharmacy
eng
Copyright (c) 2021 Johnson Ajeh Isaac, Kokonne Elizabeth Ekere, Ekeh Ezekiel, Isa Hayatu Galadima, Rashida Abdulahi, Ayuba Samali
oai:journal.umpr.ac.id:article/2597
2022-04-03T14:01:50Z
bjop:Nat-Pro-Dev
"220228 2022 eng "
2621-4814
dc
Peel-off Kefir Mask Arachi (Arachis hypogaea L.): Characterization and Antioxidant Activity
Khairunnisa, Amalia
Universitas Lambung Mangkurat http://ulm.ac.id
Viogenta, Pratika
Universitas Lambung Mangkurat http://ulm.ac.id
Kartinah, Nani
Universitas Lambung Mangkurat http://ulm.ac.id https://orcid.org/0000-0003-1365-3732
Rahman, Fathur
Universitas Lambung Mangkurat http://ulm.ac.id
Mulia, Mulia
Universitas Lambung Mangkurat http://ulm.ac.id
This study aims to determine the best formulation for the peel-off mask Arachi or peanut (Arachis hypogaea L). Arachis hypogaea kefir as an active ingredient is added with variations in the concentration of F1 (0.5%) and F2 (2%) (w/v). Organoleptic tests, homogeneity, dry time, and pH were carried out on the peel-off mask that had been made. Antioxidant test (DPPH methods) was performed on masks F1 and F2. The results showed that the peel-off mask of A. hypogaea kefir had the best antioxidant activity at a concentration of 2% (F2) kefir with an IC50 value of 1.865 ppm and was very active. The characteristics of the peel-off mask have good physical stability, proven by not experiencing a change in color, odor, being homogeneous, having good dispersion power, and having a dry time ranging from 10-23 minutes. The pH value of the peel-off mask preparation is 4.52, and it is appropriate with SNI and the pH balance of normal human skin. The peel-off mask of A. hypogaea kefir can be produced because has good physical stability and antioxidant activity.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-02-28 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/2597
Borneo Journal of Pharmacy; Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
eng
Copyright (c) 2022 Amalia Khairunnisa, Pratika Viogenta, Nani Kartinah, Fathur Rahman, Mulia Mulia
oai:journal.umpr.ac.id:article/2943
2022-04-03T14:01:30Z
bjop:Nat-Pro-Dev
"220228 2022 eng "
2621-4814
dc
Cytotoxic Effect of the Paku Atai Merah (Angiopteris ferox Copel) Fraction on MCF-7 and HeLa Cells and its Compound Profile by GC-MS
Nur, Syamsu
Sekolah Tinggi Ilmu Farmasi Makassar https://stifa.ac.id/ https://orcid.org/0000-0001-7730-4414
Aisyah, Andi Nur
Sekolah Tinggi Ilmu Farmasi Makassar https://stifa.ac.id/ https://orcid.org/0000-0002-5243-384X
Lukitaningsih, Endang
Universitas Gadjah Mada https://www.ugm.ac.id/ https://orcid.org/0000-0002-4969-5128
Rumiyati, Rumiyati
Universitas Gadjah Mada https://www.ugm.ac.id/ https://orcid.org/0000-0002-6969-0359
Fadri, Alfat
Sekolah Tinggi Ilmu Farmasi Makassar https://stifa.ac.id/ https://orcid.org/0000-0002-0751-0404
Marwati, Marwati
Sekolah Tinggi Ilmu Farmasi Makassar https://stifa.ac.id/ https://orcid.org/0000-0001-5243-9048
Cancer is a condition of abnormal cell proliferation of tissue cells in the body that becomes malignant. It can attack other parts of the body and affect the normal function of the body organs. The sample used in this study was tubers of paku atai merah (Angiopteris ferox Copel), then extracted using 96% ethanol eluent to obtain a thick extract. The ethanolic extract of A. ferox was fractionated using column chromatography to get the active fraction to characterize the compound using thin-layer chromatography and gas chromatography-mass spectroscopy (GC-MS) and tested its cytotoxic effectiveness on MCF-7 and HeLa cancer cells. The results of this study were obtained from fractionation using the column chromatography method to get sub-fraction C and the results of compound characterization using GC-MS and obtained variations in the class of compounds contained in the sample: amino acids, glucosinolates, alkaloids, flavonoids, and terpenoids. Based on the cytotoxic effect test of sub-fraction C on MCF-7 cells, the results obtained moderate cytotoxic effects with an IC50 value of 61.027 µg/mL, and HeLa cells had an IC50 value of 521.03 µg/mL, which was categorized as having a weak cytotoxic effect. Based on the results obtained from this study, it can be concluded that sub-fraction C of A. ferox tubers has a cytotoxic effect on MCF-7 cells to be used as a reference for tracing pure compounds from A. ferox tuber.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-02-28 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/2943
Borneo Journal of Pharmacy; Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
eng
Copyright (c) 2022 Syamsu Nur, Andi Nur Aisyah, Endang Lukitaningsih, Rumiyati Rumiyati, Alfat Fadri, Marwati Marwati
oai:journal.umpr.ac.id:article/2968
2022-04-03T14:01:28Z
bjop:Nat-Pro-Dev
"220228 2022 eng "
2621-4814
dc
Anti-inflammatory Activity of Water Extract of Luvunga sarmentosa (BI.) Kurz Stem in the Animal Models
Deyulita, Sabar
Universitas Airlangga https://www.unair.ac.id/
Ilmi, Hilkatul
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0002-3844-8877
Nisa, Hanifah Khairun
Universitas Airlangga https://www.unair.ac.id/
Tumewu, Lidya
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0003-3132-8909
Widyawaruyanti, Aty
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0003-4639-1599
Hafid, Achmad Fuad
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0002-0570-7975
The study was aimed to determine the anti-inflammatory activity of water extract of the Luvunga sarmentosa stem in an animal model. Twenty-five Wistar rats were divided into five groups (n=5). Group 1 was administered 0.9% normal saline (negative control), group 2 was administered 150 mg/kg diclofenac sodium (positive control), and groups 3 to 5 were administered 50, 300, and 550 mg/kg BW of L. sarmentosa extract, respectively. Carrageenan was injected subcutaneously into each rat's subplantar region of the left hind paw. The paw volume was measured using a plethysmometer. The results showed that the water extract of L. sarmentosa stem (doses of 50, 300, and 550 mg/kg BW) significantly reduced the paw edema volume from the 4th to 5th hour compared to the negative control. The percent inhibition of edema at the 5th hour is 47.45; 46.95; 50.39%. The first phase of the edema (1st and 2nd hour) was not affected by the extract. Meanwhile, diclofenac sodium decreased paw edema volume from the 1st to 5th hour with a percent inhibition of 95.90% at the 5th hour. The histopathology result is relevant to the percentage inhibition of edema. Treatment with L. sarmentosa extract showed slight improvement, destruction of epidermal tissue, hyperkeratotic skin, and subepidermal edema. Meanwhile, positive control showed no inflammatory signs with normal keratin, subepidermal, and subcutaneous layers. The water extract of L. sarmentosa stem has anti-inflammatory activity. This extract effectively reduces the paw edema volume in the late phase with decreased neutrophil infiltration.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-02-28 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/2968
Borneo Journal of Pharmacy; Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
eng
Copyright (c) 2022 Sabar Deyulita, Hilkatul Ilmi, Hanifah Khairun Nisa, Lidya Tumewu, Aty Widyawaruyanti, Achmad Fuad Hafid
oai:journal.umpr.ac.id:article/2983
2022-04-03T14:01:23Z
bjop:Nat-Pro-Dev
"220228 2022 eng "
2621-4814
dc
Free Radical Scavenging and Analgesic Activities of 70% Ethanol Extract of Luvunga sarmentosa (BI.) Kurz from Central Kalimantan
Islamiati, Utami
Universitas Airlangga https://www.unair.ac.id/
Nisa, Hanifah Khairun
Universitas Airlangga https://www.unair.ac.id/
Ilmi, Hilkatul
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0002-3844-8877
Tumewu, Lidya
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0003-3132-8909
Adianti, Myrna
Universitas Airlangga https://www.unair.ac.id/
Wahyuni, Tutik Sri
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0003-2049-7774
Widyawaruyanti, Aty
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0003-4639-1599
Hafid, Achmad Fuad
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0002-0570-7975
Luvunga sarmentosa, commonly known as saluang belum, is widely used in Kalimantan to relieve pains, rheumatism, boost the immune system, and fever. The research on the free radical scavenging and analgesic effect of the L. sarmentosa stem extract has not been reported. This study aimed to evaluate the free radical scavenging and analgesic activity of the ethanol extract of L. sarmentosa. The L. sarmentosa stem was extracted using 70% ethanol and tested for free radical scavenging using the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and analgesic activity, acetic acid-induced writhing test, and hot plate test in an animal model. The results showed that the 70% ethanol extract of the L. sarmentosa had an anti-free radical scavenging and analgesic activity. The extract has weak free radical scavenging with an IC50 value of 293.45 µg/mL. Analgesic activity using the writhing test indicated that the extract significantly reduced the writhes count after oral administration in a dose-dependent manner compared to the negative control. Extract at a dose of 550 mg/kg BW can reduce the writhing test by 67.60% compared to others. In contrast, the diclofenac sodium reduced the number of writhes by 74.74%. While in a hot plate, the extract at a dose of 550 mg/kg BW produced a maximum possible analgesia (MPA) of 17.64%, lower than the MPA of diclofenac sodium (51.01%). Analgesic activity of the extract has higher inhibition on the writhing test than on the hot plate. The extract could be responsible for the peripheral mechanism by inhibiting the prostaglandin biosynthesis.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-02-28 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/2983
Borneo Journal of Pharmacy; Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
eng
Copyright (c) 2022 Utami Islamiati, Hanifah Khairun Nisa, Hilkatul Ilmi, Lidya Tumewu, Myrna Adianti, Tutik Sri Wahyuni, Aty Widyawaruyanti, Achmad Fuad Hafid
oai:journal.umpr.ac.id:article/3052
2022-04-03T14:01:22Z
bjop:Nat-Pro-Dev
"220228 2022 eng "
2621-4814
dc
Cancer Statistics and Anticancer Potential of Peganum harmala Alkaloids: A Review
Nasibova, Tohfa
Azerbaijan Medical University http://www.amu.edu.az/en/home https://orcid.org/0000-0003-4221-3656
Cancer is one of the most common diseases in the world. Although it develops in various organs and tissues, some species maintain a stable position in the ranking. Although the cancer causes are different, the specific grounds for each type are also noted. Sometimes the increase in incidents and mortality is associated with geographical reasons. Increases in statistics, expensive and chemotherapeutic methods focus on plant-based substances. One of such potential plants is Peganum harmala, which contains alkaloids such as harmine, harmaline, harmol, and harmalol. The effects of these compounds on many cancer cells have been tested, and positive results have been obtained. This fact reinforces the claim that more in-depth research on noted alkaloids is needed.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-02-28 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/3052
Borneo Journal of Pharmacy; Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy
eng
Copyright (c) 2022 Tohfa Nasibova
oai:journal.umpr.ac.id:article/3153
2022-07-20T09:01:37Z
bjop:Nat-Pro-Dev
"220531 2022 eng "
2621-4814
dc
Formulation of Anti Acne Loose Powder of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) Ethanol Extract
Novaryatiin, Susi
Universitas Muhammadiyah Palangkaraya http://umpr.ac.id/ https://orcid.org/0000-0003-0696-6546
Amalia, Nursheilla Rizky
Universitas Muhammadiyah Palangkaraya http://umpr.ac.id/
Ardhany, Syahrida Dian
Universitas Muhammadiyah Palangkaraya http://umpr.ac.id/ https://orcid.org/0000-0002-8606-8991
Bawang dayak (Eleutherine bulbosa (Mill.) Urb is one of the notable Iridaceae family, originating from Central Kalimantan, Indonesia. Previous studies have reported that E. bulbosa ethanol extract and its cream preparation have antibacterial properties that can inhibit the growth of acne-causing bacteria and cause no significant skin adverse reaction. This study aimed to make a loose powder preparation from E. bulbosa ethanol extract and determine its physical evaluation and antibacterial activity. Loose powder formulation was made with various concentrations of E. bulbosa ethanol extract, F0 (0%), F1 (5%), F2 (10%), and F3 (15%). Loose powder evaluates for organoleptic, homogeneity, and antibacterial activity by the disc diffusion method. The results show that E. bulbosa ethanol extract can produce a loose powder formulation. The color of the formula is rather yellow (F0), brown-ash (F1), and light brown (F2 and F3), which has a typical mint odor, smooth texture, and homogeneous. All formulations inhibited the growth of Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus. This present study showed the potential of Formula 3 (F3) as an anti-acne loose powder due to its organoleptic properties, homogeneity, and antibacterial activity, which has the largest inhibition zone diameter of 17.6 ± 3.1 mm.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-05-31 00:00:00
Peer-reviewed Article
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https://journal.umpr.ac.id/index.php/bjop/article/view/3153
Borneo Journal of Pharmacy; Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy
eng
Copyright (c) 2022 Susi Novaryatiin, Nursheilla Rizky Amalia, Syahrida Dian Ardhany
oai:journal.umpr.ac.id:article/3155
2023-08-14T09:00:35Z
bjop:Nat-Pro-Dev
"230531 2023 eng "
2621-4814
dc
Ointment Formulation of Tapak Dara (Catharanthus roseus (L.) G. Don) Flower Ethanol Extract and its Activity in Burn-Healing
Leny, Leny
Institut Kesehatan Helvetia https://helvetia.ac.id/ https://orcid.org/0000-0002-3119-0375
Situmorang, Tetty Noverita Khairani
Institut Kesehatan Helvetia https://helvetia.ac.id/ https://orcid.org/0000-0001-6546-8753
Siagian, Rensus
Institut Kesehatan Helvetia https://helvetia.ac.id/
Hafiz, Ihsanul
Institut Kesehatan Helvetia https://helvetia.ac.id/ https://orcid.org/0000-0003-2888-3661
Iskandar, Benni
Taipei Medical University https://eng.tmu.edu.tw/ https://orcid.org/0000-0002-5635-8357
Treatment done on burn wounds is intended to provide local therapy to heal as quickly as possible. The content of secondary metabolites in the tapak dara (Catharanthus roseus (L.) G. Don) flower can help the healing process of burns, namely alkaloids, saponins, tannins, and flavonoids. Alkaloids act as antibacterial; saponins can trigger collagen formation; tannins as astringents that cause shrinkage of skin pores and stop minor bleeding in wounds; and flavonoids have anti-inflammatory effects. This study aimed to formulate an ointment of C. roseus flower ethanol extract and determine its physical characteristics such as organoleptic test, homogeneity, pH value, dispersion, and stability test of the preparation and examine the activity as a burn healer in white male rats. The research data were analyzed statistically using the ANOVA method, followed by the LSD test (least significant difference) to see how the ointment-containing extract reduced the diameter and percentage of the burn wounds. The results show that all ethanol extracts of C. roseus flower ointments met the requirements for its physical characteristic tests. It offers a good activity as a burn healer in white male rats. The most effective concentration is an ointment containing 15% of ethanol extract from C. roseus flower (F3 group), which shows a significant difference (p <0.05) from the blank and the other group formula in burn wound healing.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-05-31 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/3155
Borneo Journal of Pharmacy; Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
eng
Copyright (c) 2023 Leny Leny, Tetty Noverita Khairani Situmorang, Rensus Siagian, Ihsanul Hafiz, Benni Iskandar
oai:journal.umpr.ac.id:article/3262
2022-09-23T19:28:23Z
bjop:Nat-Pro-Dev
"220831 2022 eng "
2621-4814
dc
Metabolite Profiling of the Environmental-Controlled Growth of Marsilea crenata Presl. and Its In Vitro and In Silico Antineuroinflammatory Properties
Ma'arif, Burhan
Universitas Islam Negeri Maulana Malik Ibrahim https://www.uin-malang.ac.id/ https://orcid.org/0000-0001-9182-343X
Muslikh, Faisal Akhmal
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0002-9611-7937
Amalia, Dilla
Universitas Islam Negeri Maulana Malik Ibrahim https://www.uin-malang.ac.id/
Mahardiani, Anisah
Universitas Islam Negeri Maulana Malik Ibrahim https://www.uin-malang.ac.id/ https://orcid.org/0000-0001-5686-9299
Muchlasi, Luthfi Achmad
Universitas Islam Negeri Maulana Malik Ibrahim https://www.uin-malang.ac.id/
Riwanti, Pramudita
Universitas Hang Tuah https://hangtuah.ac.id/ https://orcid.org/0000-0002-8556-7385
Taek, Maximus Markus
Universitas Katolik Widya Mandira https://www.unwira.ac.id/ https://orcid.org/0000-0002-4597-2167
Laswati, Hening
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0003-4512-4018
Agil, Mangestuti
Universitas Airlangga https://www.unair.ac.id/ https://orcid.org/0000-0002-2300-9214
This study was aimed to evaluate the metabolite contents and antineuroinflammatory potential of Marsilea crenata Presl. grown under a controlled environmental condition. The antineuroinflammatory test has been carried out in vitro using ethanolic extract of M. crenata leaves on HMC3 microglia cells. An in silico approach was applied to predict the active compounds of the extract. The HMC3 microglia cells were induced with IFNγ to create prolonged inflammatory conditions and then treated with 96% ethanolic extract of the M. crenata leaves of 62.5, 125, and 250 μg/mL. The expression of MHC II was analyzed using the ICC method with the CLSM instrument. Metabolites of the extract were profiled using UPLC-QToF-MS/MS instrument and MassLynx 4.1 software. In silico evaluation was conducted with molecular docking on 3OLS protein using PyRx 0.8 software, and physicochemical properties of the compounds were analyzed using SwissADME webtool. The ethanolic extract of M. crenata leaves could reduce the MHC II expression in HMC3 microglia cells in all concentrations with the values 97.458, 139.574, and 82.128 AU. The result of metabolite profiling found 79 compounds in the extract. In silico evaluation showed that 19 compounds gave agonist interaction toward 3OLS, and three met all parameters of physicochemical analysis. The ethanolic extract of the environmental-controlled growth of M. crenata leaves antineuroinflammatory activity on HMC3 microglia cells. The extract was predicted to contain some phytoestrogen compounds which act as 3OLS agonists.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-08-31 00:00:00
Peer-reviewed Article
application/pdf
application/xml
https://journal.umpr.ac.id/index.php/bjop/article/view/3262
Borneo Journal of Pharmacy; Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy
eng
Copyright (c) 2022 Burhan Ma'arif, Faisal Akhmal Muslikh, Dilla Amalia, Anisah Mahardiani, Luthfi Achmad Muchlasi, Pramudita Riwanti, Maximus Markus Taek, Hening Laswati, Mangestuti Agil
oai:journal.umpr.ac.id:article/3760
2022-12-17T14:09:42Z
bjop:Nat-Pro-Dev
"221130 2022 eng "
2621-4814
dc
Phenolic and Flavonoid Content of Black Mulberry (Morus nigra L.) Stem and Their Evaluation Antioxidant and Cytotoxic Profile
Nur, Syamsu
Sekolah Tinggi Ilmu Farmasi Makassar https://webfront.stifa.ac.id/ https://orcid.org/0000-0001-7730-4414
Sami, Fitriyanti Jumaetri
Sekolah Tinggi Ilmu Farmasi Makassar https://webfront.stifa.ac.id/ https://orcid.org/0000-0002-4556-303X
Marwati, Marwati
Sekolah Tinggi Ilmu Farmasi Makassar https://webfront.stifa.ac.id/ https://orcid.org/0000-0001-5243-9048
Nursamsiar, Nursamsiar
Sekolah Tinggi Ilmu Farmasi Makassar https://webfront.stifa.ac.id/ https://orcid.org/0000-0001-5923-8812
Fadri, Alfat
Sekolah Tinggi Ilmu Farmasi Makassar https://webfront.stifa.ac.id/ https://orcid.org/0000-0002-0751-0404
Khairuddin, Khairuddin
Sekolah Tinggi Ilmu Farmasi Makassar https://webfront.stifa.ac.id/ https://orcid.org/0000-0003-1301-018X
The black mulberry (Morus nigra) plant has been widely developed for its bioactivity as natural medicine. This study evaluated plant extracts' total phenolic and flavonoid content and their correlation to M. nigra stem's antioxidant activity and toxicity. Dry powder from the M. nigra stem was extracted by maceration with 96% ethanol to obtain a thick extract (TE) and fractionated using hexane (HF), ethyl acetate (EAF), and ethanol-aqueous (EF). The samples were analyzed for a compound using reagents and the determination of total phenolic and flavonoid content. The samples were evaluated for antioxidant activity using several parameters and their cytotoxic effects using the BSLT method. Identification of compounds in EAF was confirmed to contain phenolic, flavonoids, alkaloids, saponins, tannins, steroids, and terpenoids. EAF showed higher phenolic and flavonoid content than others. The evaluation of antioxidant activity showed that extracts and fractions from M. nigra stems showed the ability to reduce ions and free radicals. EF sample has activity in reducing Mo (IV) ion by TAC method of 98.82±0.53 µM/mg, indicating substantial antioxidant capacity. In addition, EAF samples showed potential activity in reducing DPPH, hydroxyl, and peroxide radicals in the β-carotene bleaching method with IC50 values of 12.13, 42.06, and 57.6 µg/mL, respectively. Similar activity was also seen in the cytotoxic effect of a robust EAF sample with an LC50 value of 16.31 µg/mL. The results show that EAF can be developed as a raw material for traditional medicine as an antioxidant and anticancer candidate with a significant flavonoid and phenolics content.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-11-30 00:00:00
Peer-reviewed Article
application/pdf
text/xml
https://journal.umpr.ac.id/index.php/bjop/article/view/3760
Borneo Journal of Pharmacy; Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy
eng
Copyright (c) 2022 Syamsu Nur, Fitriyanti Jumaetri Sami, Marwati Marwati, Nursamsiar Nursamsiar, Alfat Fadri, Khairuddin Khairuddin
oai:journal.umpr.ac.id:article/3817
2024-03-13T03:22:19Z
bjop:Nat-Pro-Dev
"231130 2023 eng "
2621-4814
dc
Formulation and Evaluation of Nanoemulsion Kelakai (Stenochlaena palustris) Herbs with Composition of Smix (Tween 80 and Glycerin) and Pine Oil
Helsawati, Helsawati
Lambung Mangkurat University https://ulm.ac.id/id/
Ratnapuri, Prima Happy
Lambung Mangkurat University https://ulm.ac.id/id/
Fitriana, Mia
Lambung Mangkurat University https://ulm.ac.id/id/ https://orcid.org/0009-0004-8725-8991
Kelakai (Stenochlaena palustris) herb is a typical South Kalimantan plant containing bioactive substances that can serve as antioxidants. It can be formulated into nanoemulsions to increase bioavailability in the skin. This study aimed to determine the ratio of pine oil and Smix (tween 80 and glycerin) as the optimal base for nanoemulsion based on the highest percent transmittance and to determine the physical characteristics of the S. palustris herb extract nanoemulsion with variations in the amount of extract. Bases of nanoemulsion formula were optimized using a ternary phase diagram and D-Optimal Mixture Design. Nanoemulsion contained three extract concentrations: 0.1; 0.25; and 0.5%, respectively, and nanoemulsion was tested for physical characteristics. The results of this study were a light yellow to light brown, clear, and transparent, with a characteristic weak-strong odor, forming an O/W nanoemulsion. Increasing the concentration of the extract significantly increased the viscosity and decreased the pH and percent transmittance. This study concluded that variations in extract concentration affected the percent transmittance, organoleptic, pH, viscosity, and the optimal ratio of nanoemulsion components was 1% pine oil, 9% Smix, and 90% water.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-11-30 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/3817
Borneo Journal of Pharmacy; Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
eng
Copyright (c) 2023 Helsawati Helsawati, Prima Happy Ratnapuri, Mia Fitriana
oai:journal.umpr.ac.id:article/4034
2024-03-13T03:31:28Z
bjop:Nat-Pro-Dev
"240229 2024 eng "
2621-4814
dc
Total Flavonoid Levels in n-hexane and Ethyl Acetate Fractions of Rosmarinus officinalis L. Leaves and Their Antibacterial and Antioxidant Activities
Esati, Ni Ketut
Sekolah Tinggi Farmasi Mahaganesha https://www.farmasimahaganesha.ac.id/
La, Elisabeth Oriana Jawa
Sekolah Tinggi Farmasi Mahaganesha https://www.farmasimahaganesha.ac.id/ https://orcid.org/0000-0002-2290-6634
Sudiasih, Ni Putu
Sekolah Tinggi Farmasi Mahaganesha https://www.farmasimahaganesha.ac.id/
Saniasih, Ni Nyoman Dina
Sekolah Tinggi Farmasi Mahaganesha https://www.farmasimahaganesha.ac.id/
The rosemary (Rosmarinus officinalis L.) is a plant of the Lamiaceae tribe that has not been widely studied regarding its pharmacological activity, known from previous studies to contain secondary metabolites of flavonoids. Flavonoids are phenol compounds with many pharmacological activities, including antibacterials and antioxidants. This study aims to determine the total flavonoid levels in R. officinalis leaves and their effect on antibacterial and antioxidant activities. This research began with the preparation of ethanol extract from R. officinalis leaves, then the fractionation of the extract produced n-hexane and ethyl acetate fractions. Total flavonoid levels were determined against both fractions by UV-Vis spectrophotometry. A test of the fraction’s antibacterial activity against Staphylococcus aureus was performed using the disc diffusion method. The antioxidant test is carried out by the DPPH method. The total flavonoid content of the ethyl acetate fraction is 47.437 ± 1.947%, higher than the n-hexane fraction. Test antibacterial and antioxidant activity showed more significant results in the ethyl acetate fraction than in the n-hexane fraction. In conclusion, the total flavonoid levels of ethyl acetate fraction are directly proportional to the antibacterial and antioxidant activities of R. officinalis leaves.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2024-02-29 00:00:00
Peer-reviewed Article
https://journal.umpr.ac.id/index.php/bjop/article/view/4034
Borneo Journal of Pharmacy; Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
eng
Copyright (c) 2024 Ni Ketut Esati, Elisabeth Oriana Jawa La, Ni Putu Sudiasih, Ni Nyoman Dina Saniasih
oai:journal.umpr.ac.id:article/4239
2023-11-09T08:03:08Z
bjop:Nat-Pro-Dev
"230830 2023 eng "
2621-4814
dc
Utilization, Phytochemistry and Biological Activity of Hua gabonii Pierre ex De Wild.
Mbadiko, Clément Mutunda
Université de Kinshasa https://www.unikin.ac.cd/ https://orcid.org/0000-0002-9573-2487
Bongo, Gédéon Ngiala
Université de Kinshasa https://www.unikin.ac.cd/ https://orcid.org/0000-0003-0710-0832
Ngbolua, Jean-Paul Koto-te-Nyiwa
Université de Kinshasa https://www.unikin.ac.cd/ https://orcid.org/0000-0002-0066-8153
Yandju, Marie Claire Dembo D’A Letshu
Université de Kinshasa https://www.unikin.ac.cd/
Mpiana, Pius Tshimankinda
Université de Kinshasa https://www.unikin.ac.cd/ https://orcid.org/0000-0002-8590-6017
Mbemba, Théophile Fundu
Université de Kinshasa https://www.unikin.ac.cd/ https://orcid.org/0000-0001-6627-6323
Although few studies are reported, Hua gabonii remains scientifically unknown due to the lack of studies. However, this aromatic plant is used in developing countries as a condiment or in traditional medicine to treat various ailments. The literature reported that this species is rich in proteins, essential amino acids, and vitamins C and E. Its fruits would present an appreciable antioxidant power. Therefore, given its numerous uses in tropical countries, H. gabonii is a good candidate for further studies.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-08-30 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/4239
Borneo Journal of Pharmacy; Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy
eng
Copyright (c) 2023 Clément Mutunda Mbadiko, Gédéon Ngiala Bongo, Jean-Paul Koto-te-Nyiwa Ngbolua, Marie Claire Dembo D’A Letshu Yandju, Pius Tshimankinda Mpiana, Théophile Fundu Mbemba
oai:journal.umpr.ac.id:article/4448
2024-03-13T03:31:28Z
bjop:Nat-Pro-Dev
"240229 2024 eng "
2621-4814
dc
An Initial Investigation of the Potential of Robusta Coffee, Arabica Coffee, and Caffeine in Asthma Treatment through the Evaluation of 5-Lipoxygenase Inhibition Activity
Yuniarta, Tegar Achsendo
University of Surabaya https://orcid.org/0000-0002-5326-7636
Handayani, Rosita
Airlangga University https://orcid.org/0000-0002-3304-3328
Numerous studies have documented the potential of coffee to aid in asthma prevention. Nevertheless, research into how coffee influences asthma management has not been available. One known mechanism by which asthma medications work involves inhibiting 5-Lipoxygenase (5-LOX) activity. This study aims to determine the potency of Coffea canephora var. Robusta extract (CRE), Coffea arabica (CAE), and caffeine are the primary isolates against 5-LOX activity. Extraction was performed by a reflux procedure using 96% ethanol with a sample-total solvent ratio of 1:10, an extraction time of 1 hour, and the extraction was conducted in triplicate. Fractionation was carried out by liquid-liquid partition using a chloroform-water system. Caffeine further purification was performed by the sublimation method, and the inhibition of 5-LOX activity was evaluated using the spectrophotometric method at λ = 234 nm. Apigenin was used as a positive control. From the experiment conducted, the IC50 of the CRE, CAE, caffeine, and apigenin against 5-LOX was 32.2 ± 1.4 µg/mL, 42.1 ± 2.3 µg/mL, 14.3 ± 1.6 µg/mL, and 7.4 ± 1.7 µg/mL, respectively. Continued efforts to isolate bioactive compounds from coffee extract led to the discovery of caffeine, which exhibited a more potent inhibitory effect on 5-LOX. The inhibition of 5-LOX activity by caffeine occurs in a non-competitive manner.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2024-02-29 00:00:00
Peer-reviewed Article
https://journal.umpr.ac.id/index.php/bjop/article/view/4448
Borneo Journal of Pharmacy; Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
eng
Copyright (c) 2024 Tegar Achsendo Yuniarta, Rosita Handayani
oai:journal.umpr.ac.id:article/4546
2023-08-14T09:00:35Z
bjop:Nat-Pro-Dev
"230531 2023 eng "
2621-4814
dc
Antioxidant Activity and Phytochemicals of Locally Consumed Plant Foods from Baguio City, Philippines
Bueno, Paolo Robert P.
University of the Philippines Manila https://www.upm.edu.ph/ https://orcid.org/0000-0002-8127-7516
Cabrera, Rachel Camille R.
University of the Philippines Manila https://www.upm.edu.ph/
Yu, Gracia Fe B.
University of the Philippines Manila https://www.upm.edu.ph/ https://orcid.org/0000-0003-3489-923X
In the Philippines, Baguio City – known as the “City of Pines” – holds the country’s major source of temperate climate vegetables. With increased dietary awareness, the consumption of plant foods rich in antioxidants has become relevant. Twenty-nine methanolic extracts from Baguio-produced plant foods were evaluated for antioxidant potential using DPPH, ferric reduction antioxidant power (FRAP), metal chelation, superoxide anion, nitric oxide, hydroxyl radical scavenging activities, MTT reduction, and phytochemical tests. Fagopyrum tataricum leaves, Vaccinium myrtoides fruit, and Morus alba fruit showed the most effective DPP radical, concentration-dependent reducing power, but low metal chelating activity. Solanum tuberosum tuber (22.86±63.26%) showed effective concentration-dependent chelating activity at 125 μg/mL. Citrus aurantium fruit (26.77±9.24%) and Raphanus raphanistrum root (41.13±0.11%) demonstrated an effective scavenging activity against superoxide anions at 45.5 μg/mL. Significant nitric oxide scavenging activity was observed in some fruits. Brassica oleracea Cab leaves (54.36 ± 2.38%) showed the highest inhibitory activity against hydroxyl radicals at 166.7 μg/mL. Phytochemical analyses showed that most plant samples revealed the presence of glycosides, terpenes/terpenoids, and steroids/phytosterols, while few contained phenolic and tannin components. These phytochemicals may explain the dual behavior as an antioxidant or a prooxidant observed. Thus, determining food antioxidant component types and their concentration is necessary to maximize the potential to scavenge oxidants.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-05-31 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/4546
Borneo Journal of Pharmacy; Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
eng
Copyright (c) 2023 Paolo Robert P. Bueno, Rachel Camille R. Cabrera, Gracia Fe B. Yu
oai:journal.umpr.ac.id:article/4662
2023-11-09T08:03:08Z
bjop:Nat-Pro-Dev
"230830 2023 eng "
2621-4814
dc
Characterization of Secondary Metabolites Profile from Methanol Fraction of Temurui (Murraya koenigii (Linn.) Spreng) Leaves Using UPLC-MS
Permata, Intania
Politeknik ATI Padang https://poltekatipdg.ac.id/ https://orcid.org/0000-0002-5856-6483
Santoni, Adlis
Universitas Andalas https://www.unand.ac.id/ https://orcid.org/0000-0001-6391-0069
Afrizal, Afrizal
Universitas Andalas https://www.unand.ac.id/
Afandi, Trisno
Politeknik Teknologi Kimia Industri Medan https://ptki.ac.id/ https://orcid.org/0000-0002-9173-8603
The leaves of the temurui (Murraya koenigii (Linn.) Spreng) plant have long been known and used by Indonesian and even Asian people as a traditional medicine to treat stomach aches and diabetes. This study aimed to determine the secondary metabolite profile of the methanol extract of M. koenigii leaves. Murraya koenigii leaves fine powder was extracted in stages using n-hexane, ethyl acetate, and methanol. Each extract was prepared using a mixture of water, formic acid, acetonitrile, and formic acid, then injected into the UPLC-MS, then analyzed with MassLynx and ChemSpider. The results showed that the metabolite profile of the methanol extract of M. koenigii leaves contained 13 compounds, including phenolic, steroid, and alkaloid groups. Those compounds could be tested to identify their bioactivity.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-08-30 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/4662
Borneo Journal of Pharmacy; Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy
eng
Copyright (c) 2023 Intania Permata, Adlis Santoni, Afrizal Afrizal, Trisno Afandi
oai:journal.umpr.ac.id:article/5013
2024-03-13T03:22:19Z
bjop:Nat-Pro-Dev
"231130 2023 eng "
2621-4814
dc
The Potential of Natural Based-Skincare Cosmetic Ingredients for Naturally Glowing Skin
Oktaviani, Dede Jihan
Padjadjaran University https://www.unpad.ac.id/ https://orcid.org/0009-0002-9473-6440
Susilawati, Yasmiwar
Padjadjaran University https://www.unpad.ac.id/ https://orcid.org/0000-0003-1907-3405
Tjitraresmi, Ami
Padjadjaran University https://www.unpad.ac.id/ https://orcid.org/0000-0002-7990-0567
Zuhrotun, Ade
Padjadjaran University https://www.unpad.ac.id/ https://orcid.org/0000-0002-7451-9118
The use of skincare products is the primary need in modern society. There is an increase in awareness of maintaining beauty and healthy skin, as well as the desire to have naturally glowing, healthy skin, which is in line with the rise in the use of cosmetics, especially skincare products. Nature provides many plants and marine resources (such as algae) that can be utilized as essential ingredients for cosmetics preparations with various benefits such as cleansers, toners, moisturizers, and sun protectors, a primary series of skincare products to gain naturally glowing, healthy skin. This review aims to provide information about plants and marine algae that can be used as skincare ingredients, their phytochemical contents, and their function in cosmetics to achieve naturally glowing skin. Various plants and marine algae categorized based on their benefits as skincare have great potential to be developed as ingredients in cosmetic preparations. The content of phytochemical compounds in these plants and marine algae supports these benefits. Each skincare category has major phytochemical compounds that play a role in providing these benefits.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-11-30 00:00:00
Peer-reviewed Article
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/5013
Borneo Journal of Pharmacy; Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
eng
2012-2023
Copyright (c) 2023 Dede Jihan Oktaviani, Yasmiwar Susilawati, Ami Tjitraresmi, Ade Zuhrotun
oai:journal.umpr.ac.id:article/6743
2024-03-13T03:31:28Z
bjop:Nat-Pro-Dev
"240229 2024 eng "
2621-4814
dc
Assessment of In Vivo Antioxidant Activity of Anogeissus latifolia Bark in Ethanol-induced Oxidative Stress in Rats
Yerra, Rajeshwar
Komar University of Science and Technology https://komar.edu.iq/ https://orcid.org/0009-0004-1119-0441
Abdullah, Trefa M.
Komar University of Science and Technology https://komar.edu.iq/ https://orcid.org/0000-0002-2026-1617
Substances with hepatoprotective activity can inhibit oxidation to protect the body's cells from the damaging effects of oxidation. It can bind to free oxygen radicals preventing these radicals from damaging healthy cells. The present investigation aims to evaluate the in vivo antioxidant potential of the bark of Anogeissus latifolia in ethanol-induced hepatotoxicity. Animals were treated with the methanol extract of A. latifolia (MEAL) for 15 days and induced oxidative stress with a single dose of ethanol (36 mg/kg po). The activity was measured by measuring oxidative stress markers such as lipid peroxidation, reduced glutathione, superoxide dismutase, and catalase levels in hepatotoxic rats. Administration of MEAL at 100 and 200 mg/kgBW marked decreased ethanol-induced elevation levels of oxidative stress markers and liver in a dose-dependent manner. The effects of the extract were compared with the Silymarin standard at 100 mg/kgBW. In methanol extract-treated animals, the toxic effect of ethanol was controlled significantly (P <0.05) by restoration of the levels of enzymes as compared to the normal and standard groups. The results concluded that the MEAL bark possesses significant in vivo antioxidant activity and can be exploited in protecting hepatic tissue from oxidative stress.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2024-02-29 00:00:00
Peer-reviewed Article
https://journal.umpr.ac.id/index.php/bjop/article/view/6743
Borneo Journal of Pharmacy; Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
eng
Copyright (c) 2024 Rajeshwar Yerra, Trefa M. Abdullah