2024-03-28T12:44:04Z
https://journal.umpr.ac.id/index.php/bjop/oai
oai:journal.umpr.ac.id:article/236
2019-10-11T09:04:12Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/236
2019-10-11T09:04:12Z
I
Vol. 1 No. 1 (2018): Borneo Journal of Pharmacy; 11-15
Uji Daya Hambat Ekstrak Etanol Daun Jerangau Hijau terhadap Staphylococcus aureus
Peer-reviewed Article
Novaryatiin, Susi; Universitas Muhammadiyah Palangkaraya
Pratomo, Guntur Satrio; Universitas Muhammadiyah Palangkaraya
Yunari, Cindia; Universitas Muhammadiyah Palangkaraya
2018-05-01
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/236
Microbiology
Array
Jerangau Hijau is a medicinal plant believed by the people of Central Kalimantan to have an efficacy of treating fever, postpartum injuries, and anti-inflammatory. Based on previous research, Jerangau Hijau is known to contain chemical compounds namely flavonoids and saponins that have activity as an antibacterial. The purpose of this study was to find out whether the ethanolic extract of Jerangau Hijau leaves able to inhibit the growth of Staphylococcus aureus bacteria and to know the concentration of ethanolic extract of Jerangau Hijau leaves that able to inhibit the growth of Staphylococcus aureus bacteria. This research was conducted using the Kirby-Bauer method with disc paper. The extraction process was carried out by percolation method using 96% ethanol solvent. The results showed that the ethanolic extract of Jerangau Hijau leaves was able to inhibit the growth of Staphylococcus aureus bacteria, at concentrations of 1%, 5%, 10%, and 15% with mean inhibitory zones respectively 22±0.2 mm; 32.3±1.4 mm; 26.5±3.8 mm; and 13.1±3 mm.
oai:journal.umpr.ac.id:article/237
2019-10-11T09:04:09Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/237
2019-10-11T09:04:09Z
I
Vol. 1 No. 1 (2018): Borneo Journal of Pharmacy; 16-18
Uji Daya Hambat Ekstrak Etanol Batang Saluang Belum terhadap Bakteri Escherichia coli
Peer-reviewed Article
Handayani, Rezqi; Universitas Muhammadiyah Palangkaraya
Qamariah, Nurul; Universitas Muhammadiyah Palangkaraya
Mardova, Saftaria Ayu; Universitas Muhammadiyah Palangkaraya
2018-05-01
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/237
Microbiology
Array
Saluang Belum one of the herbal plants that have the benefits as a traditional medicine in Central Kalimantan. People in Central Kalimantan trusted Saluang Belum stem has an empirical benefit as a stamina enhancing agent and as an antioxidant. From previous research, Saluang Belum stem has a secondary metabolite that was saponin and tannin. Of these two secondary metabolites scientifically have pharmacological effects one of which was able to inhibit bacterial growth. To prove it in this research, the inhibitory test of ethanol extract of Saluang Belum stem from the growth of Escherichia coli bacteria. The inhibitory test method used in this study was the diffusion method using a variety of concentrations of 0.5%, 1%, 5%, 10%, and 15%. The result of this research, that there was no inhibition zone on the media used in all concentration. From these results can be concluded Saluang Belum stem ethanol extract unable to inhibit the growth of E. coli bacteria at concentrations of 0.5%, 1%, 5%, 10%, and 15%.
oai:journal.umpr.ac.id:article/368
2019-12-01T13:46:09Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/368
2019-12-01T13:46:09Z
I
Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy; 77-80
RETRACTED: Antibacterial Activity Test Combination of Kencur (Kaempferia galanga L) Rhizome and Sapodilla (Manilkara zapota L) Leaf Extract against Escherichia coli
Peer-reviewed Article
Ilhani, Amanda Fadilah; Poltekkes Kemenkes Medan
Ismedsyah, Ismedsyah; Poltekkes Kemenkes Medan
2018-11-01
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/368
Array
This article has been retracted as a result of multiple publications from the article by the relevant author. Similar articles can be found at the URL https://ejurnal.stmik-budidarma.ac.id/index.php/pelita/article/view/892
oai:journal.umpr.ac.id:article/370
2019-12-01T13:54:50Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/370
2019-12-01T13:54:50Z
I
Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy; 81-84
Uji Aktivitas Antioksidan Ekstrak Etanol Buah dan Biji Buah Kalangkala (Litsea angulata) asal Kalimantan Selatan
Peer-reviewed Article
Saputri, Revita; Sekolah Tinggi Ilmu Kesehatan Borneo Lestari
Susiani, Eka Fitri; Sekolah Tinggi Ilmu Kesehatan Borneo Lestari
2018-11-01
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/370
Phytochemistry
Array
Free radicals are atoms or molecules, having one or more unpaired electrons. Increased production of free radicals can cause oxidative stress and cause many pathological conditions, e.g. cancers, heart diseases, and other diseases. The antioxidant can inhibit oxidative stress. Kalangkala (Litsea angulata) usually found in the South Kalimantan that can be used as an antioxidant. The study aimed to determine the antioxidant activity of ethanolic extract of Kalangkala fruits and seeds from South Kalimantan. Antioxidant activity was conducted qualitatively and quantitative uses the method DPPH. The result of the antioxidant activity of ethanolic extract of Kalangkala fruits and seeds qualitatively showed the presence of yellow spots on a purple background at Thin Layer Chromatography (TLC). The result of the activity of ethanolic extract of Kalangkala seeds quantitatively obtained IC50 value was 48.78 ppm and activity of ethanolic extract of Kalangkala fruits quantitatively obtained IC50 value was 243.14 ppm. Ethanolic extract of Kalangkala fruits and seeds from South Kalimantan has antioxidant activity.
oai:journal.umpr.ac.id:article/427
2019-12-01T14:18:27Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/427
2019-12-01T14:18:27Z
I
Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy; 85-88
Antibacterial Activity of Ethanolic Extract of Sangkareho (Callicarpa longifolia Lam.) against Staphylococcus epidermidis
Peer-reviewed Article
Novaryatiin, Susi; Universitas Muhammadiyah Palangkaraya
Sari, Asma'ul Ayuriska; Universitas Muhammadiyah Palangkaraya
Mulyani, Evi; Universitas Muhammadiyah Palangkaraya
2018-11-01
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/427
Microbiology
Array
One of the plants believed as traditional medicine by the Dayak tribes in Central Kalimantan was Sangkareho (Callicarpa longifolia Lam.). This plant was usually used as traditional medicine by society in Puruk Cahu, Murung Raya Regency, Central Kalimantan and empirically believed could cure skin disease such as wound infection. This study was aimed to determine the antibacterial activity of ethanolic extract of Sangkareho (Callicarpa longifolia Lam). Antibacterial activity of ethanolic extract of Sangkareho was performed using disc diffusion technique, with four variations of concentration of 1%, 5%, 10%, and 15%. In this present study showed that ethanolic extract of Sangkareho has antibacterial activity against Staphylococcus epidermidis, wherein the resulting inhibition zone diameter was 7.3±0.8 mm, 8.3±1.2 mm, 10.5±0.5 mm, and 12.2±0.7 mm, respectively. Further research is needed to obtain an antibacterial activity of the fraction of Sangkareho.
oai:journal.umpr.ac.id:article/689
2022-11-09T14:16:41Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/689
2022-11-09T14:16:41Z
I
Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy; 24-30
Phytochemical Screening of Sunflower Leaf (Helianthus annuus) and Anting-Anting (Acalypha indica Linn) Plant Ethanol Extract
Peer-reviewed Article
Ngibad, Khoirul; Universitas Maarif Hasyim Latif
2019-05-31
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/689
Phytochemistry
Array
Many local plants in Indonesia were used as traditional medicines, such as sunflower (Helianthus annuus) and anting-anting (Acalypha indica Linn) plants. Both of them can be used as an antimalarial, antibacterial, antifungal, analgesic, and antihyperlipidemic. This study aims to provide an overview of the secondary metabolites groups contained in sunflower leaf and anting-anting plants for the testing of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and sesquiterpenoids. This study included the extraction of sunflower leaves and anting-anting plants separately using the maceration method for 24 hours with 80% ethanol solvent. The stirring was aided by a shaker for three hours. Each extract was tested by phytochemicals with reagents. The results of phytochemical tests with reagents showed that 80% ethanol extract of sunflower leaves contained an alkaloid, tannin, steroid, and sesquiterpenoid compounds whereas anting-anting plants contained an alkaloid, flavonoid, and triterpenoid compounds.
oai:journal.umpr.ac.id:article/928
2022-11-11T07:46:41Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/928
2022-11-11T07:46:41Z
I
Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy; 108-113
Antibacterial Activity Test of Ethanol Extract Pineapple (Ananas comosus (L.) Merr.) Peel against Growth of Propionibacterium acnes
Peer-reviewed Article
Fitriyanti, Fitriyanti; Sekolah Tinggi Ilmu Kesehatan Borneo Lestari
Hendrawan, Muhammad Nur Rahman; Sekolah Tinggi Ilmu Kesehatan Borneo Lestari
Astuti, Karunita Ika; Sekolah Tinggi Ilmu Kesehatan Borneo Lestari
2019-11-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/928
Natural Product Development
Array
Pineapple peel (Ananas comosus (L.) Merr.) is waste from the pineapple fruit. The purpose of this study was to determine the content of pineapple peel extract and to antibacterial activity in various concentrations effective in inhibiting the growth of Propionibacterium acnes. The pineapple peel extract is made by using the extraction method in the form of maceration. The method used in the inhibitory test using the three replication samples in each treatment group. The sample consisted of 10 treatment groups ie pineapple peel extract concentration 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, 87.5%, and 100%, as well as positive and negative control. The results obtained from pineapple peel screening contain flavonoid and saponin compounds. The data analysis shows that pineapple peel extract concentrations of 50%, 62.5%, 75%, 87.5%, and 100% had inhibitory zones with the medium-strong category while clindamycin as the control has a strong inhibition zone. The conclusion of this research proves that pineapple peel extract has antibacterial power to P. acnes with effective concentration is 100% with the strong category.
oai:journal.umpr.ac.id:article/1070
2022-11-11T07:46:41Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/1070
2022-11-11T07:46:41Z
I
Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy; 114-118
Antioxidant Activity of Ethanolic Extract from Tandui Leaves (Mangifera rufocostata Kosterm.) by DPPH Radical Scavenging Method
Peer-reviewed Article
Saputri, Revita; Sekolah Tinggi Ilmu Kesehatan Borneo Lestari
Melati, Tia Mariati Risma; Sekolah Tinggi Ilmu Kesehatan Borneo Lestari
Fitriyanti, Fitriyanti; Sekolah Tinggi Ilmu Kesehatan Borneo Lestari
2019-11-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/1070
Natural Product Development
Array
Tandui (Mangifera rufocostata Kosterm.) is a typical plant from South Kalimantan which belongs to the genus of Mangifera. Several species of Mangifera are known to have antioxidant activity. This study aimed to determine the antioxidant activity of ethanol extract of Tandui leaves. Tandui leaves that were obtained from the maceration method used 70% ethanol. Antioxidant activity was conducted quantitative using the DPPH (2,2-diphenyl-1-picrylhydrazil) method. The result of the antioxidant activity of Ethanol extract of Tandui leaves quantitatively obtained IC50 value was 60.7042 µg/mL. The ethanol extract of Tandui leaves has strong antioxidant activity
oai:journal.umpr.ac.id:article/1242
2020-04-15T01:05:28Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/1242
2020-04-15T01:05:28Z
I
Vol. 3 No. 1 (2020): Borneo Journal of Pharmacy; 44-51
Test on the Antioxidant Activities of Methanol Extract of Bidara Leaves (Ziziphus spina-christi L.) using the DPPH Radical Immersion Method
Peer-reviewed Article
Pambudi, Dwi Bagus; Universitas Muhammadiyah Pekajangan Pekalongan
Fajriyah, Nuniek Nizmah; Universitas Muhammadiyah Pekajangan Pekalongan
Shalekhah, Vidiah Rizka; Universitas Muhammadiyah Pekajangan Pekalongan
2020-02-27
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/1242
Pharmacognosy-Phytochemistry
Array
Bidara (Ziziphus spina-christi L.) is a tropical tree originating from Sudan in which it is commonly known as "Nebeq" in Saudi Arabia. It is of a bioactive compound - a flavonoid compound, which is the potential to be used as an antioxidant. It is capable of inhibiting any cell damages caused by free radicals. This study aimed to measure the activities of the free radicals in methanol extracts of Z. spina-christi leaves. The process of extracting the Z. spina-christi leaves was carried out through the maceration method using methanol as a solvent. The qualitative analysis of chemical compounds with certain eluents using thin-layer chromatography (TLC) was purposely to determine the groups of active compounds in extracts. The measurement of antioxidant activities was carried out using the 1,1-Diphenyl-2-picryl Hidrazyl (DPPH) immersion method in which absorption was measured at a maximum wavelength of 513 nm. The results showed that the methanol extract of Z. spina-christi leaves had a very weak antioxidant activity with the IC50 value of 466.804 μg/ml. The results of the bioautographic profile showed the presence of flavonoid compounds, phenols, saponins, and tannins.
oai:journal.umpr.ac.id:article/1415
2020-09-04T12:20:36Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/1415
2020-09-04T12:20:36Z
I
Vol. 3 No. 3 (2020): Borneo Journal of Pharmacy; 179-189
Advantages of Herbal Over Allopathic Medicine in the Management of Kidney and Urinary Stones Disease
Peer-reviewed Article
Nimesh, Saurabh; Shri Gopichand College of Pharmacy
Ashwlayan, Vrish Dhwaj; Meerut Institute of Engineering and Technology
Rani, Rubi; NKBR College of Pharmacy and Research Centre
Prakash, Om; Shri Gopichand College of Pharmacy
2020-08-31
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/1415
Pharmacology
Array
Kidney and urinary stone disease (Nephrolithiasis and urolithiasis) are the condition where urinary stones or calculi are formed in the urinary tract. The problem of urinary stones is very ancient; these stones are found in all parts of the urinary tract, kidney, ureters, and the urinary bladder and may vary considerably in size. It is a common disease estimated to occur in approximately 12% of the population, with a recurrence rate of 70-81% in males and 47-60% in females. The treatment of kidney and urinary stone diseases such as a western (allopathy) medicine and surgery is now in trends. However, most people preferred plant-based (herbal) therapy because of the overuse of allopathic drugs, which results in a higher incidence rate of adverse or severe side effects. Therefore, people every year turn to herbal therapy because they believe plant-based medicine is free from undesirable side effects, although herbal medicines are generally considered to be safe and effective. In the present article, an attempt has been made to emphasize an herbal therapy is better than allopathic therapy for the management of the kidney and urinary stone disease.
oai:journal.umpr.ac.id:article/1500
2020-12-08T00:50:01Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/1500
2020-12-08T00:50:01Z
I
Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy; 249-256
Determination of Antiradical Activity, Total Phenolic, and Total Flavonoid Contents of Extracts and Fractions of Langsat (Lansium domesticum Coor.) Seeds
Peer-reviewed Article
Yamin, Yamin; Universitas Halu Oleo
Ruslin, Ruslin; Universitas Halu Oleo
Sabarudin, Sabarudin; Universitas Halu Oleo
Sida, Nurramadhani A; Universitas Halu Oleo
Kasmawati, Henny; Universitas Halu Oleo
Diman, La Ode Muhammad; Universitas Halu Oleo
2020-11-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/1500
Antiradical
Array
Lansium domesticum Coor. is a fruit species from the Meliaceae family, which is a tropical plant native to Southeast Asia. Local citizens call it langsat, longkong, or duku and have used it as traditional medicine. The seeds of L. domesticum are used as a fever medicine, its bark is used to treat scorpion sting, and its leaves are used to repel mosquitoes. Because of its various uses, it is necessary to explore the antiradical potential of L. domesticum seeds. This study aims to determine the antiradical potential of L. domesticum seeds extract and fractions by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and to discover compounds that act as antiradical. Lansium domesticum seed powder was macerated with methanol, and then the extract was concentrated using a rotary evaporator and fractionated by n-hexane and ethyl acetate. The antiradical assay was conducted on extract and fractions by using DPPH radicals. Phenolic and flavonoid contents from extract and fractions were also tested. The ethyl acetate fraction obtained strong antiradical potential with an IC50 value of 8.938 ± 0.031 µg/mL. Total phenolic and flavonoid contents of ethyl acetate fraction were higher with values of 58.25 ± 0.501 mgGAE/g sample and 75.123 ± 0.175 mgQE/g sample, respectively. Correlation of phenolic and flavonoid contents, which inhibited radicals had R2 values of 0.9182 and 0.7658. Ethyl acetate fraction of L. domesticum seeds had very strong antiradical activity. Further isolation is expected to be conducted to discover which compounds are the most responsible as antiradical.
oai:journal.umpr.ac.id:article/1578
2021-05-20T02:39:24Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/1578
2021-05-20T02:39:24Z
I
Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy; 36-42
The Combination of Turmeric (Curcuma domestica) Rhizome Extract and Collagen in A Serum Formulation as an Antioxidant
Peer-reviewed Article
Pratiwi, Denia; Universitas Abdurrab
Sidoretno, Wahyu Margi; Universitas Abdurrab
Aisah, Nur; Universitas Abdurrab
2021-02-28
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/1578
Natural Product
Array
Turmeric (Curcuma domestica) has nutritious compounds called curcuminoids, which can be used as antioxidants. As an antioxidant, C. domestica extract can be used to ward off free radicals that damage collagen and elastin, a protein that keeps skin moist. This study aimed to determine the antioxidant activity of serum combined with collagen's addition using the DPPH method. The DPPH was made at a concentration of 80 μg/mL, and the absorption was read at a wavelength of 520 nm using a microplate rider. The study was conducted by making six formulations: F0, F1, F2, F3, F4, and F5 obtained the results of serum made from C. domestica extract that could inhibit free radicals and meet the physical evaluation test requirements of serum. Furthermore, the formula was made using only one active ingredient and only collagen to determine the extract or collagen's antioxidant activity. The results obtained indicate that collagen had a supporting role in adding antioxidant activity apart from its extract. The highest % inhibition value at F5 with 90.526% could ward off free radicals.
oai:journal.umpr.ac.id:article/1589
2021-05-20T02:39:24Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/1589
2021-05-20T02:39:24Z
I
Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy; 43-50
Formulation and Antibacterial Activity of Liquid Soap Containing Ketapang (Terminalia catappa L.) Leaves Extract
Peer-reviewed Article
Dewi, Asiska Permata; Universitas Abdurrab
Mardhiyani, Dini; Universitas Abdurrab
2021-02-28
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/1589
Natural Product
Array
Ketapang (Terminalia catappa L.) is traditionally used by the community to treat the skin's infections caused by bacteria or fungi. In this study, T. catappa leaves extract was added to the liquid soap formula as an antibacterial. The purpose of this study was to determine the secondary metabolite compounds contained in T. catappa leaves extract, physical evaluation of the preparation, and antibacterial activity of liquid soap. Liquid soap formula was made with various concentrations of T. catappa leaves extract F0 (0%), F1 (1%), F2 (2%), and F3 (3%). The resulting soap was evaluated for organoleptic, pH, high foam, homogeneity, irritation, and its activity against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli using the disc diffusion method. The results showed that the T. catappa leaves extract contained flavonoids, tannins, saponins, and triterpenoids. The liquid soap formula F0 was clear, while F1, F2, and F3 had the characteristics of brown-dark brown, homogeneous, pH between 4.6-5.2, foam stability between 67-72%, which was not significantly different and stable after five minutes of testing, and it did not irritate the skin. Terminalia catappa leaves extracts liquid soap has antibacterial activity at a concentration of 1%, 2%, and 3%, with the largest inhibition zone diameter produced by S. aureus.
oai:journal.umpr.ac.id:article/1644
2020-12-08T00:49:43Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/1644
2020-12-08T00:49:43Z
I
Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy; 257-261
Potential of Frangipani (Plumeria alba) Leaves Extract as Ultra Violet Protection
Peer-reviewed Article
Putra, I Gusti Ngurah Agung Windra Wartana; Universitas Bali Internasional
Arimbawa, Putu Eka; Universitas Bali Internasional
Artini, Ni Putu Rahayu; Universitas Bali Internasional
2020-11-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/1644
Phytochemistry
Array
Sunlight is the source of life and energy. Besides that, sunlight also creates skin challenges such as sunburn, pigmentation, wrinkles, dermatitis, aging, and skin cancer. Natural sunscreen protection is a popular and preferred way among various regions of the world to reduce sunlight's harmful effect. This study aimed to determine the potential of frangipani (Plumeria alba) leaves extract in some concentrations as ultraviolet protection. Plumeria alba extract contained secondary metabolites such as flavonoids, phenolics, and alkaloids that function as impeding ultraviolet radiation. This study used an experimental method consisting of four treatments and six replications. This study shows that the extract with concentration 2500; 5000; 7500; and 10000 ppm consecutively have SPF value of 6.24; 12.00; 18.45; and 22.64. It can be concluded the P. alba leaves extract potential as ultraviolet protection.
oai:journal.umpr.ac.id:article/1817
2021-05-20T02:39:24Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/1817
2021-05-20T02:39:24Z
I
Vol. 4 No. 1 (2021): Borneo Journal of Pharmacy; 51-56
Formulation, Organoleptic Evaluation, and Acceptability of Various Teas from Underutilized Nutritious Herbs Compared with Marketed Chinese and Yellow Lipton Tea
Peer-reviewed Article
Ehoche, Elijah Edache; Federal University of Technology Minna
Patel, Parth; Humera Khan College of Pharmacy
Madu, Chijioke; University of Abuja
Adejoh, Johnson; University of Abuja
2021-02-28
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/1817
Natural product
Array
Herbal teas are nutrient, antioxidant, and hydration-rich brews made from herbs and spices and taken for various purposes. The objective of this study was to formulate tea from clove (Syzygium aromaticum), leaves of lemongrass (Cymbopogon citratus), guava (Psidium guajava), and moringa (Moringa oleifera), as well as compared with Chinese and yellow Lipton Tea. The samples were analyzed for comparative sensory analysis using the 7 points hedonic scale. The sensory evaluation result demonstrated that the color of the clove tea sample (5.87) was most acceptable by participants, while the lemongrass tea (4.46) sample was least acceptable amongst all the tea samples. The clove remained the most accepted tea for aroma (6.07), taste (5.92), texture (5.76), general appearance (5.74), and general acceptability (5.93), in 7 points hedonic scale. However, all tea samples were had significant acceptable scores above average (p <0.05). Owing to the above results, these herbs can be successfully used to produce tea of relatively good quality to encourage herbs' local consumption and stay healthy.
oai:journal.umpr.ac.id:article/1955
2021-09-15T08:41:27Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/1955
2021-09-15T08:41:27Z
I
Vol. 4 No. 3 (2021): Borneo Journal of Pharmacy; 192-201
In-vitro Cytotoxicity and In-silico Insights of the Multi-target Anticancer Candidates from Haplophyllum tuberculatum
Peer-reviewed Article
Al-Nour, Mosab Yahya; Omdurman Islamic University
Arbab, Ahmed H; University of Khartoum
Parvez, Mohammad Khalid; King Saud University
Mohamed, Arwa Y; Omdurman Islamic University
Al-Dosari, Mohammed S; King Saud University
2021-08-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/1955
Array
This study aimed to investigate the anticancer activity of Haplophyllum tuberculatum(Forsk.) aerial parts ethanol extract and fractions and reveal the potential anticancer targets, binding modes, pharmacokinetics, and toxicity properties of its phytoconstituents. MTT assay was used to investigate the anticancer activity. TargetNet, ChemProt version 2.0, and CLC-Pred web servers were used for virtual screening, and Cresset Flare software was used for molecular docking with the 26 predicted targets. Moreover, pkCSM, swiss ADME, and eMolTox web servers were used to predict pharmacokinetics and safety. Ethanolic extracts of H. tuberculatum on HepG2 and HeLa cell lines showed promising activities with IC50 values 54.12 and 48.1 µg/mL, respectively. Further, ethyl acetate fraction showed the highest cytotoxicity on HepG2 and HeLa cell lines with IC50 values 41.7 and 52.31 µg/mL. Of 70 compounds screened virtually, polygamain, justicidin A, justicidin B, haplotubine, kusunokinin, and flindersine were predicted as safe anticancer drugs candidates. They showed the highest binding scores with targets involved in cell growth, proliferation, survival, migration, tumor suppression, induction of apoptosis, metastasis, and drug resistance. Our findings revealed the potency of H. tuberculatum as a source of anticancer candidates that further studies should support.
oai:journal.umpr.ac.id:article/2154
2021-09-15T08:41:13Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/2154
2021-09-15T08:41:13Z
I
Vol. 4 No. 3 (2021): Borneo Journal of Pharmacy; 202-209
Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa
Peer-reviewed Article
Septiana, Eris; Indonesian Institute of Sciences
Rizka, Nurul Maulida; Universitas Pancasila
Yadi, Yadi; Indonesian Institute of Sciences
Simanjuntak, Partomuan; Indonesian Institute of Sciences
2021-08-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/2154
Array
Traditionally and scientifically, research has shown that Orthosiphon aristatus and Oryza sativa L. var. glutinosa have antidiabetic activity. The combination of two medicinal plants can increase their biological activity. This study aimed to determine the antidiabetic activity of O. aristatus and O. sativa L. var. glutinosa on single and combined extracts. Phytochemical screening of the single extract was done qualitatively. The α-glucosidase inhibitory method was used as an antidiabetic activity. The results showed that every extract contained alkaloids, steroids/triterpenoids, flavonoids, tannins, quinones, and coumarins. A single extract of O. sativa L. var glutinosa, O. aristatus, and their combinations (1:1, 1:2, and 2:1) had an α-glucosidase enzyme inhibitory activity with an IC50 value of 67.82, 80.93, 73.81, 88.72, and 61.51 µg/ml, respectively. The combination shows that the ratio of 1:1 was nearly additive, 1:2 was slight to moderate antagonism, and 2:1 was moderate to slight synergism. The combination of 96% ethanol extract of O. sativa L. var. glutinosa and O. aristatus in a ratio of 2:1 was the most effective in increasing its inhibitory activity.
oai:journal.umpr.ac.id:article/2544
2022-02-15T08:20:08Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/2544
2022-02-15T08:20:08Z
I
Vol. 4 No. 4 (2021): Borneo Journal of Pharmacy; 333-344
Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves
Peer-reviewed Article
Isaac, Johnson Ajeh; National Institute for Pharmaceutical Research and Development
Ekere, Kokonne Elizabeth; National Institute for Pharmaceutical Research and Development
Ezekiel, Ekeh; National Institute for Pharmaceutical Research and Development
Galadima, Isa Hayatu; National Institute for Pharmaceutical Research and Development
Abdulahi, Rashida; National Institute for Pharmaceutical Research and Development
Samali, Ayuba; National Institute for Pharmaceutical Research and Development
2021-11-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/2544
Formulation
Array
Traditionally, the leafy part of Andrographis paniculata and Moringa oleifera have been widely reported to manage hypertension. Investigation of its pharmacological actions justifies its use. As part of formulation studies to standardize them, this study focused on their compaction and compression properties. Compacts equivalent to 250 mg of A. paniculata and M. oleifera were produced by compressing powders and granules at various compression pressure. Results show that M. oleifera met the WHO limit for ash values. Relative density values for granulated batches were higher, while their moisture content values were lower when compared to those of direct compression. The result from Heckel plots shows that batches deform mainly by plastic flow. For Kawakita plots, values of 1/b show that batches containing microcrystalline cellulose were less cohesive. The plot of tensile strength signifies that granulated batches achieved maximum crushing strength faster at low pressure. Formulations containing maize starch were shown to have higher percent porosity, and granulated batches gave higher values for apparent density-pressure relationship and lower friability values. Tablets produced by the wet granulation method showed better compression and compaction properties than those formulated by direct compression.
oai:journal.umpr.ac.id:article/2597
2022-04-03T14:01:50Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/2597
2022-04-03T14:01:50Z
I
Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy; 42-47
Peel-off Kefir Mask Arachi (Arachis hypogaea L.): Characterization and Antioxidant Activity
Peer-reviewed Article
Khairunnisa, Amalia; Universitas Lambung Mangkurat
Viogenta, Pratika; Universitas Lambung Mangkurat
Kartinah, Nani; Universitas Lambung Mangkurat
Rahman, Fathur; Universitas Lambung Mangkurat
Mulia, Mulia; Universitas Lambung Mangkurat
2022-02-28
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/2597
Array
This study aims to determine the best formulation for the peel-off mask Arachi or peanut (Arachis hypogaea L). Arachis hypogaea kefir as an active ingredient is added with variations in the concentration of F1 (0.5%) and F2 (2%) (w/v). Organoleptic tests, homogeneity, dry time, and pH were carried out on the peel-off mask that had been made. Antioxidant test (DPPH methods) was performed on masks F1 and F2. The results showed that the peel-off mask of A. hypogaea kefir had the best antioxidant activity at a concentration of 2% (F2) kefir with an IC50 value of 1.865 ppm and was very active. The characteristics of the peel-off mask have good physical stability, proven by not experiencing a change in color, odor, being homogeneous, having good dispersion power, and having a dry time ranging from 10-23 minutes. The pH value of the peel-off mask preparation is 4.52, and it is appropriate with SNI and the pH balance of normal human skin. The peel-off mask of A. hypogaea kefir can be produced because has good physical stability and antioxidant activity.
oai:journal.umpr.ac.id:article/2943
2022-04-03T14:01:30Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/2943
2022-04-03T14:01:30Z
I
Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy; 48-55
Cytotoxic Effect of the Paku Atai Merah (Angiopteris ferox Copel) Fraction on MCF-7 and HeLa Cells and its Compound Profile by GC-MS
Peer-reviewed Article
Nur, Syamsu; Sekolah Tinggi Ilmu Farmasi Makassar
Aisyah, Andi Nur; Sekolah Tinggi Ilmu Farmasi Makassar
Lukitaningsih, Endang; Universitas Gadjah Mada
Rumiyati, Rumiyati; Universitas Gadjah Mada
Fadri, Alfat; Sekolah Tinggi Ilmu Farmasi Makassar
Marwati, Marwati; Sekolah Tinggi Ilmu Farmasi Makassar
2022-02-28
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/2943
Array
Cancer is a condition of abnormal cell proliferation of tissue cells in the body that becomes malignant. It can attack other parts of the body and affect the normal function of the body organs. The sample used in this study was tubers of paku atai merah (Angiopteris ferox Copel), then extracted using 96% ethanol eluent to obtain a thick extract. The ethanolic extract of A. ferox was fractionated using column chromatography to get the active fraction to characterize the compound using thin-layer chromatography and gas chromatography-mass spectroscopy (GC-MS) and tested its cytotoxic effectiveness on MCF-7 and HeLa cancer cells. The results of this study were obtained from fractionation using the column chromatography method to get sub-fraction C and the results of compound characterization using GC-MS and obtained variations in the class of compounds contained in the sample: amino acids, glucosinolates, alkaloids, flavonoids, and terpenoids. Based on the cytotoxic effect test of sub-fraction C on MCF-7 cells, the results obtained moderate cytotoxic effects with an IC50 value of 61.027 µg/mL, and HeLa cells had an IC50 value of 521.03 µg/mL, which was categorized as having a weak cytotoxic effect. Based on the results obtained from this study, it can be concluded that sub-fraction C of A. ferox tubers has a cytotoxic effect on MCF-7 cells to be used as a reference for tracing pure compounds from A. ferox tuber.
oai:journal.umpr.ac.id:article/2968
2022-04-03T14:01:28Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/2968
2022-04-03T14:01:28Z
I
Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy; 56-62
Anti-inflammatory Activity of Water Extract of Luvunga sarmentosa (BI.) Kurz Stem in the Animal Models
Peer-reviewed Article
Deyulita, Sabar; Universitas Airlangga
Ilmi, Hilkatul; Universitas Airlangga
Nisa, Hanifah Khairun; Universitas Airlangga
Tumewu, Lidya; Universitas Airlangga
Widyawaruyanti, Aty; Universitas Airlangga
Hafid, Achmad Fuad; Universitas Airlangga
2022-02-28
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/2968
Array
The study was aimed to determine the anti-inflammatory activity of water extract of the Luvunga sarmentosa stem in an animal model. Twenty-five Wistar rats were divided into five groups (n=5). Group 1 was administered 0.9% normal saline (negative control), group 2 was administered 150 mg/kg diclofenac sodium (positive control), and groups 3 to 5 were administered 50, 300, and 550 mg/kg BW of L. sarmentosa extract, respectively. Carrageenan was injected subcutaneously into each rat's subplantar region of the left hind paw. The paw volume was measured using a plethysmometer. The results showed that the water extract of L. sarmentosa stem (doses of 50, 300, and 550 mg/kg BW) significantly reduced the paw edema volume from the 4th to 5th hour compared to the negative control. The percent inhibition of edema at the 5th hour is 47.45; 46.95; 50.39%. The first phase of the edema (1st and 2nd hour) was not affected by the extract. Meanwhile, diclofenac sodium decreased paw edema volume from the 1st to 5th hour with a percent inhibition of 95.90% at the 5th hour. The histopathology result is relevant to the percentage inhibition of edema. Treatment with L. sarmentosa extract showed slight improvement, destruction of epidermal tissue, hyperkeratotic skin, and subepidermal edema. Meanwhile, positive control showed no inflammatory signs with normal keratin, subepidermal, and subcutaneous layers. The water extract of L. sarmentosa stem has anti-inflammatory activity. This extract effectively reduces the paw edema volume in the late phase with decreased neutrophil infiltration.
oai:journal.umpr.ac.id:article/2983
2022-04-03T14:01:23Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/2983
2022-04-03T14:01:23Z
I
Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy; 63-70
Free Radical Scavenging and Analgesic Activities of 70% Ethanol Extract of Luvunga sarmentosa (BI.) Kurz from Central Kalimantan
Peer-reviewed Article
Islamiati, Utami; Universitas Airlangga
Nisa, Hanifah Khairun; Universitas Airlangga
Ilmi, Hilkatul; Universitas Airlangga
Tumewu, Lidya; Universitas Airlangga
Adianti, Myrna; Universitas Airlangga
Wahyuni, Tutik Sri; Universitas Airlangga
Widyawaruyanti, Aty; Universitas Airlangga
Hafid, Achmad Fuad; Universitas Airlangga
2022-02-28
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/2983
Array
Luvunga sarmentosa, commonly known as saluang belum, is widely used in Kalimantan to relieve pains, rheumatism, boost the immune system, and fever. The research on the free radical scavenging and analgesic effect of the L. sarmentosa stem extract has not been reported. This study aimed to evaluate the free radical scavenging and analgesic activity of the ethanol extract of L. sarmentosa. The L. sarmentosa stem was extracted using 70% ethanol and tested for free radical scavenging using the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and analgesic activity, acetic acid-induced writhing test, and hot plate test in an animal model. The results showed that the 70% ethanol extract of the L. sarmentosa had an anti-free radical scavenging and analgesic activity. The extract has weak free radical scavenging with an IC50 value of 293.45 µg/mL. Analgesic activity using the writhing test indicated that the extract significantly reduced the writhes count after oral administration in a dose-dependent manner compared to the negative control. Extract at a dose of 550 mg/kg BW can reduce the writhing test by 67.60% compared to others. In contrast, the diclofenac sodium reduced the number of writhes by 74.74%. While in a hot plate, the extract at a dose of 550 mg/kg BW produced a maximum possible analgesia (MPA) of 17.64%, lower than the MPA of diclofenac sodium (51.01%). Analgesic activity of the extract has higher inhibition on the writhing test than on the hot plate. The extract could be responsible for the peripheral mechanism by inhibiting the prostaglandin biosynthesis.
oai:journal.umpr.ac.id:article/3052
2022-04-03T14:01:22Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/3052
2022-04-03T14:01:22Z
I
Vol. 5 No. 1 (2022): Borneo Journal of Pharmacy; 71-80
Cancer Statistics and Anticancer Potential of Peganum harmala Alkaloids: A Review
Peer-reviewed Article
Nasibova, Tohfa; Azerbaijan Medical University
2022-02-28
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/3052
Array
Cancer is one of the most common diseases in the world. Although it develops in various organs and tissues, some species maintain a stable position in the ranking. Although the cancer causes are different, the specific grounds for each type are also noted. Sometimes the increase in incidents and mortality is associated with geographical reasons. Increases in statistics, expensive and chemotherapeutic methods focus on plant-based substances. One of such potential plants is Peganum harmala, which contains alkaloids such as harmine, harmaline, harmol, and harmalol. The effects of these compounds on many cancer cells have been tested, and positive results have been obtained. This fact reinforces the claim that more in-depth research on noted alkaloids is needed.
oai:journal.umpr.ac.id:article/3153
2022-07-20T09:01:37Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/3153
2022-07-20T09:01:37Z
I
Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy; 153-160
Formulation of Anti Acne Loose Powder of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) Ethanol Extract
Peer-reviewed Article
Novaryatiin, Susi; Universitas Muhammadiyah Palangkaraya
Amalia, Nursheilla Rizky; Universitas Muhammadiyah Palangkaraya
Ardhany, Syahrida Dian; Universitas Muhammadiyah Palangkaraya
2022-05-31
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/3153
Pharmacy
Array
Bawang dayak (Eleutherine bulbosa (Mill.) Urb is one of the notable Iridaceae family, originating from Central Kalimantan, Indonesia. Previous studies have reported that E. bulbosa ethanol extract and its cream preparation have antibacterial properties that can inhibit the growth of acne-causing bacteria and cause no significant skin adverse reaction. This study aimed to make a loose powder preparation from E. bulbosa ethanol extract and determine its physical evaluation and antibacterial activity. Loose powder formulation was made with various concentrations of E. bulbosa ethanol extract, F0 (0%), F1 (5%), F2 (10%), and F3 (15%). Loose powder evaluates for organoleptic, homogeneity, and antibacterial activity by the disc diffusion method. The results show that E. bulbosa ethanol extract can produce a loose powder formulation. The color of the formula is rather yellow (F0), brown-ash (F1), and light brown (F2 and F3), which has a typical mint odor, smooth texture, and homogeneous. All formulations inhibited the growth of Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus. This present study showed the potential of Formula 3 (F3) as an anti-acne loose powder due to its organoleptic properties, homogeneity, and antibacterial activity, which has the largest inhibition zone diameter of 17.6 ± 3.1 mm.
oai:journal.umpr.ac.id:article/3155
2023-08-14T09:00:35Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/3155
2023-08-14T09:00:35Z
I
Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy; 182-189
Ointment Formulation of Tapak Dara (Catharanthus roseus (L.) G. Don) Flower Ethanol Extract and its Activity in Burn-Healing
Peer-reviewed Article
Leny, Leny; Institut Kesehatan Helvetia
Situmorang, Tetty Noverita Khairani; Institut Kesehatan Helvetia
Siagian, Rensus; Institut Kesehatan Helvetia
Hafiz, Ihsanul; Institut Kesehatan Helvetia
Iskandar, Benni; Taipei Medical University
2023-05-31
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/3155
Array
Treatment done on burn wounds is intended to provide local therapy to heal as quickly as possible. The content of secondary metabolites in the tapak dara (Catharanthus roseus (L.) G. Don) flower can help the healing process of burns, namely alkaloids, saponins, tannins, and flavonoids. Alkaloids act as antibacterial; saponins can trigger collagen formation; tannins as astringents that cause shrinkage of skin pores and stop minor bleeding in wounds; and flavonoids have anti-inflammatory effects. This study aimed to formulate an ointment of C. roseus flower ethanol extract and determine its physical characteristics such as organoleptic test, homogeneity, pH value, dispersion, and stability test of the preparation and examine the activity as a burn healer in white male rats. The research data were analyzed statistically using the ANOVA method, followed by the LSD test (least significant difference) to see how the ointment-containing extract reduced the diameter and percentage of the burn wounds. The results show that all ethanol extracts of C. roseus flower ointments met the requirements for its physical characteristic tests. It offers a good activity as a burn healer in white male rats. The most effective concentration is an ointment containing 15% of ethanol extract from C. roseus flower (F3 group), which shows a significant difference (p <0.05) from the blank and the other group formula in burn wound healing.
oai:journal.umpr.ac.id:article/3262
2022-09-23T19:28:23Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/3262
2022-09-23T19:28:23Z
I
Vol. 5 No. 3 (2022): Borneo Journal of Pharmacy; 209-228
Metabolite Profiling of the Environmental-Controlled Growth of Marsilea crenata Presl. and Its In Vitro and In Silico Antineuroinflammatory Properties
Peer-reviewed Article
Ma'arif, Burhan; Universitas Islam Negeri Maulana Malik Ibrahim
Muslikh, Faisal Akhmal; Universitas Airlangga
Amalia, Dilla; Universitas Islam Negeri Maulana Malik Ibrahim
Mahardiani, Anisah; Universitas Islam Negeri Maulana Malik Ibrahim
Muchlasi, Luthfi Achmad; Universitas Islam Negeri Maulana Malik Ibrahim
Riwanti, Pramudita; Universitas Hang Tuah
Taek, Maximus Markus; Universitas Katolik Widya Mandira
Laswati, Hening; Universitas Airlangga
Agil, Mangestuti; Universitas Airlangga
2022-08-31
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/3262
Array
This study was aimed to evaluate the metabolite contents and antineuroinflammatory potential of Marsilea crenata Presl. grown under a controlled environmental condition. The antineuroinflammatory test has been carried out in vitro using ethanolic extract of M. crenata leaves on HMC3 microglia cells. An in silico approach was applied to predict the active compounds of the extract. The HMC3 microglia cells were induced with IFNγ to create prolonged inflammatory conditions and then treated with 96% ethanolic extract of the M. crenata leaves of 62.5, 125, and 250 μg/mL. The expression of MHC II was analyzed using the ICC method with the CLSM instrument. Metabolites of the extract were profiled using UPLC-QToF-MS/MS instrument and MassLynx 4.1 software. In silico evaluation was conducted with molecular docking on 3OLS protein using PyRx 0.8 software, and physicochemical properties of the compounds were analyzed using SwissADME webtool. The ethanolic extract of M. crenata leaves could reduce the MHC II expression in HMC3 microglia cells in all concentrations with the values 97.458, 139.574, and 82.128 AU. The result of metabolite profiling found 79 compounds in the extract. In silico evaluation showed that 19 compounds gave agonist interaction toward 3OLS, and three met all parameters of physicochemical analysis. The ethanolic extract of the environmental-controlled growth of M. crenata leaves antineuroinflammatory activity on HMC3 microglia cells. The extract was predicted to contain some phytoestrogen compounds which act as 3OLS agonists.
oai:journal.umpr.ac.id:article/3760
2022-12-17T14:09:42Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/3760
2022-12-17T14:09:42Z
I
Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy; 384-395
Phenolic and Flavonoid Content of Black Mulberry (Morus nigra L.) Stem and Their Evaluation Antioxidant and Cytotoxic Profile
Peer-reviewed Article
Nur, Syamsu; Sekolah Tinggi Ilmu Farmasi Makassar
Sami, Fitriyanti Jumaetri; Sekolah Tinggi Ilmu Farmasi Makassar
Marwati, Marwati; Sekolah Tinggi Ilmu Farmasi Makassar
Nursamsiar, Nursamsiar; Sekolah Tinggi Ilmu Farmasi Makassar
Fadri, Alfat; Sekolah Tinggi Ilmu Farmasi Makassar
Khairuddin, Khairuddin; Sekolah Tinggi Ilmu Farmasi Makassar
2022-11-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/3760
Array
The black mulberry (Morus nigra) plant has been widely developed for its bioactivity as natural medicine. This study evaluated plant extracts' total phenolic and flavonoid content and their correlation to M. nigra stem's antioxidant activity and toxicity. Dry powder from the M. nigra stem was extracted by maceration with 96% ethanol to obtain a thick extract (TE) and fractionated using hexane (HF), ethyl acetate (EAF), and ethanol-aqueous (EF). The samples were analyzed for a compound using reagents and the determination of total phenolic and flavonoid content. The samples were evaluated for antioxidant activity using several parameters and their cytotoxic effects using the BSLT method. Identification of compounds in EAF was confirmed to contain phenolic, flavonoids, alkaloids, saponins, tannins, steroids, and terpenoids. EAF showed higher phenolic and flavonoid content than others. The evaluation of antioxidant activity showed that extracts and fractions from M. nigra stems showed the ability to reduce ions and free radicals. EF sample has activity in reducing Mo (IV) ion by TAC method of 98.82±0.53 µM/mg, indicating substantial antioxidant capacity. In addition, EAF samples showed potential activity in reducing DPPH, hydroxyl, and peroxide radicals in the β-carotene bleaching method with IC50 values of 12.13, 42.06, and 57.6 µg/mL, respectively. Similar activity was also seen in the cytotoxic effect of a robust EAF sample with an LC50 value of 16.31 µg/mL. The results show that EAF can be developed as a raw material for traditional medicine as an antioxidant and anticancer candidate with a significant flavonoid and phenolics content.
oai:journal.umpr.ac.id:article/3817
2024-03-13T03:22:19Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/3817
2024-03-13T03:22:19Z
I
Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy; 406-416
Formulation and Evaluation of Nanoemulsion Kelakai (Stenochlaena palustris) Herbs with Composition of Smix (Tween 80 and Glycerin) and Pine Oil
Peer-reviewed Article
Helsawati, Helsawati; Lambung Mangkurat University
Ratnapuri, Prima Happy; Lambung Mangkurat University
Fitriana, Mia; Lambung Mangkurat University
2023-11-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/3817
Array
Kelakai (Stenochlaena palustris) herb is a typical South Kalimantan plant containing bioactive substances that can serve as antioxidants. It can be formulated into nanoemulsions to increase bioavailability in the skin. This study aimed to determine the ratio of pine oil and Smix (tween 80 and glycerin) as the optimal base for nanoemulsion based on the highest percent transmittance and to determine the physical characteristics of the S. palustris herb extract nanoemulsion with variations in the amount of extract. Bases of nanoemulsion formula were optimized using a ternary phase diagram and D-Optimal Mixture Design. Nanoemulsion contained three extract concentrations: 0.1; 0.25; and 0.5%, respectively, and nanoemulsion was tested for physical characteristics. The results of this study were a light yellow to light brown, clear, and transparent, with a characteristic weak-strong odor, forming an O/W nanoemulsion. Increasing the concentration of the extract significantly increased the viscosity and decreased the pH and percent transmittance. This study concluded that variations in extract concentration affected the percent transmittance, organoleptic, pH, viscosity, and the optimal ratio of nanoemulsion components was 1% pine oil, 9% Smix, and 90% water.
oai:journal.umpr.ac.id:article/4034
2024-03-13T03:31:28Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/4034
2024-03-13T03:31:28Z
I
Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Total Flavonoid Levels in n-hexane and Ethyl Acetate Fractions of Rosmarinus officinalis L. Leaves and Their Antibacterial and Antioxidant Activities
Peer-reviewed Article
Esati, Ni Ketut; Sekolah Tinggi Farmasi Mahaganesha
La, Elisabeth Oriana Jawa; Sekolah Tinggi Farmasi Mahaganesha
Sudiasih, Ni Putu; Sekolah Tinggi Farmasi Mahaganesha
Saniasih, Ni Nyoman Dina; Sekolah Tinggi Farmasi Mahaganesha
2024-02-29
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/4034
Array
The rosemary (Rosmarinus officinalis L.) is a plant of the Lamiaceae tribe that has not been widely studied regarding its pharmacological activity, known from previous studies to contain secondary metabolites of flavonoids. Flavonoids are phenol compounds with many pharmacological activities, including antibacterials and antioxidants. This study aims to determine the total flavonoid levels in R. officinalis leaves and their effect on antibacterial and antioxidant activities. This research began with the preparation of ethanol extract from R. officinalis leaves, then the fractionation of the extract produced n-hexane and ethyl acetate fractions. Total flavonoid levels were determined against both fractions by UV-Vis spectrophotometry. A test of the fraction’s antibacterial activity against Staphylococcus aureus was performed using the disc diffusion method. The antioxidant test is carried out by the DPPH method. The total flavonoid content of the ethyl acetate fraction is 47.437 ± 1.947%, higher than the n-hexane fraction. Test antibacterial and antioxidant activity showed more significant results in the ethyl acetate fraction than in the n-hexane fraction. In conclusion, the total flavonoid levels of ethyl acetate fraction are directly proportional to the antibacterial and antioxidant activities of R. officinalis leaves.
oai:journal.umpr.ac.id:article/4239
2023-11-09T08:03:08Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/4239
2023-11-09T08:03:08Z
I
Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy; 287-294
Utilization, Phytochemistry and Biological Activity of Hua gabonii Pierre ex De Wild.
Peer-reviewed Article
Mbadiko, Clément Mutunda; Université de Kinshasa
Bongo, Gédéon Ngiala; Université de Kinshasa
Ngbolua, Jean-Paul Koto-te-Nyiwa; Université de Kinshasa
Yandju, Marie Claire Dembo D’A Letshu; Université de Kinshasa
Mpiana, Pius Tshimankinda; Université de Kinshasa
Mbemba, Théophile Fundu; Université de Kinshasa
2023-08-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/4239
Array
Although few studies are reported, Hua gabonii remains scientifically unknown due to the lack of studies. However, this aromatic plant is used in developing countries as a condiment or in traditional medicine to treat various ailments. The literature reported that this species is rich in proteins, essential amino acids, and vitamins C and E. Its fruits would present an appreciable antioxidant power. Therefore, given its numerous uses in tropical countries, H. gabonii is a good candidate for further studies.
oai:journal.umpr.ac.id:article/4448
2024-03-13T03:31:28Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/4448
2024-03-13T03:31:28Z
I
Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
An Initial Investigation of the Potential of Robusta Coffee, Arabica Coffee, and Caffeine in Asthma Treatment through the Evaluation of 5-Lipoxygenase Inhibition Activity
Peer-reviewed Article
Yuniarta, Tegar Achsendo; University of Surabaya
Handayani, Rosita; Airlangga University
2024-02-29
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/4448
Array
Numerous studies have documented the potential of coffee to aid in asthma prevention. Nevertheless, research into how coffee influences asthma management has not been available. One known mechanism by which asthma medications work involves inhibiting 5-Lipoxygenase (5-LOX) activity. This study aims to determine the potency of Coffea canephora var. Robusta extract (CRE), Coffea arabica (CAE), and caffeine are the primary isolates against 5-LOX activity. Extraction was performed by a reflux procedure using 96% ethanol with a sample-total solvent ratio of 1:10, an extraction time of 1 hour, and the extraction was conducted in triplicate. Fractionation was carried out by liquid-liquid partition using a chloroform-water system. Caffeine further purification was performed by the sublimation method, and the inhibition of 5-LOX activity was evaluated using the spectrophotometric method at λ = 234 nm. Apigenin was used as a positive control. From the experiment conducted, the IC50 of the CRE, CAE, caffeine, and apigenin against 5-LOX was 32.2 ± 1.4 µg/mL, 42.1 ± 2.3 µg/mL, 14.3 ± 1.6 µg/mL, and 7.4 ± 1.7 µg/mL, respectively. Continued efforts to isolate bioactive compounds from coffee extract led to the discovery of caffeine, which exhibited a more potent inhibitory effect on 5-LOX. The inhibition of 5-LOX activity by caffeine occurs in a non-competitive manner.
oai:journal.umpr.ac.id:article/4546
2023-08-14T09:00:35Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/4546
2023-08-14T09:00:35Z
I
Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy; 190-207
Antioxidant Activity and Phytochemicals of Locally Consumed Plant Foods from Baguio City, Philippines
Peer-reviewed Article
Bueno, Paolo Robert P.; University of the Philippines Manila
Cabrera, Rachel Camille R.; University of the Philippines Manila
Yu, Gracia Fe B.; University of the Philippines Manila
2023-05-31
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/4546
Array
In the Philippines, Baguio City – known as the “City of Pines” – holds the country’s major source of temperate climate vegetables. With increased dietary awareness, the consumption of plant foods rich in antioxidants has become relevant. Twenty-nine methanolic extracts from Baguio-produced plant foods were evaluated for antioxidant potential using DPPH, ferric reduction antioxidant power (FRAP), metal chelation, superoxide anion, nitric oxide, hydroxyl radical scavenging activities, MTT reduction, and phytochemical tests. Fagopyrum tataricum leaves, Vaccinium myrtoides fruit, and Morus alba fruit showed the most effective DPP radical, concentration-dependent reducing power, but low metal chelating activity. Solanum tuberosum tuber (22.86±63.26%) showed effective concentration-dependent chelating activity at 125 μg/mL. Citrus aurantium fruit (26.77±9.24%) and Raphanus raphanistrum root (41.13±0.11%) demonstrated an effective scavenging activity against superoxide anions at 45.5 μg/mL. Significant nitric oxide scavenging activity was observed in some fruits. Brassica oleracea Cab leaves (54.36 ± 2.38%) showed the highest inhibitory activity against hydroxyl radicals at 166.7 μg/mL. Phytochemical analyses showed that most plant samples revealed the presence of glycosides, terpenes/terpenoids, and steroids/phytosterols, while few contained phenolic and tannin components. These phytochemicals may explain the dual behavior as an antioxidant or a prooxidant observed. Thus, determining food antioxidant component types and their concentration is necessary to maximize the potential to scavenge oxidants.
oai:journal.umpr.ac.id:article/4662
2023-11-09T08:03:08Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/4662
2023-11-09T08:03:08Z
I
Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy; 278-286
Characterization of Secondary Metabolites Profile from Methanol Fraction of Temurui (Murraya koenigii (Linn.) Spreng) Leaves Using UPLC-MS
Peer-reviewed Article
Permata, Intania; Politeknik ATI Padang
Santoni, Adlis; Universitas Andalas
Afrizal, Afrizal; Universitas Andalas
Afandi, Trisno; Politeknik Teknologi Kimia Industri Medan
2023-08-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/4662
Array
The leaves of the temurui (Murraya koenigii (Linn.) Spreng) plant have long been known and used by Indonesian and even Asian people as a traditional medicine to treat stomach aches and diabetes. This study aimed to determine the secondary metabolite profile of the methanol extract of M. koenigii leaves. Murraya koenigii leaves fine powder was extracted in stages using n-hexane, ethyl acetate, and methanol. Each extract was prepared using a mixture of water, formic acid, acetonitrile, and formic acid, then injected into the UPLC-MS, then analyzed with MassLynx and ChemSpider. The results showed that the metabolite profile of the methanol extract of M. koenigii leaves contained 13 compounds, including phenolic, steroid, and alkaloid groups. Those compounds could be tested to identify their bioactivity.
oai:journal.umpr.ac.id:article/5013
2024-03-13T03:22:19Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/5013
2024-03-13T03:22:19Z
I
Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy; 417-436
The Potential of Natural Based-Skincare Cosmetic Ingredients for Naturally Glowing Skin
Peer-reviewed Article
Oktaviani, Dede Jihan; Padjadjaran University
Susilawati, Yasmiwar; Padjadjaran University
Tjitraresmi, Ami; Padjadjaran University
Zuhrotun, Ade; Padjadjaran University
2023-11-30
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/5013
2012-2023
Array
The use of skincare products is the primary need in modern society. There is an increase in awareness of maintaining beauty and healthy skin, as well as the desire to have naturally glowing, healthy skin, which is in line with the rise in the use of cosmetics, especially skincare products. Nature provides many plants and marine resources (such as algae) that can be utilized as essential ingredients for cosmetics preparations with various benefits such as cleansers, toners, moisturizers, and sun protectors, a primary series of skincare products to gain naturally glowing, healthy skin. This review aims to provide information about plants and marine algae that can be used as skincare ingredients, their phytochemical contents, and their function in cosmetics to achieve naturally glowing skin. Various plants and marine algae categorized based on their benefits as skincare have great potential to be developed as ingredients in cosmetic preparations. The content of phytochemical compounds in these plants and marine algae supports these benefits. Each skincare category has major phytochemical compounds that play a role in providing these benefits.
oai:journal.umpr.ac.id:article/6743
2024-03-13T03:31:28Z
bjop:Nat-Pro-Dev
v2
https://journal.umpr.ac.id/index.php/bjop/article/view/6743
2024-03-13T03:31:28Z
I
Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Assessment of In Vivo Antioxidant Activity of Anogeissus latifolia Bark in Ethanol-induced Oxidative Stress in Rats
Peer-reviewed Article
Yerra, Rajeshwar; Komar University of Science and Technology
Abdullah, Trefa M.; Komar University of Science and Technology
2024-02-29
Authors continue to retain the copyright to the article if the article is published in the Borneo Journal of Pharmacy. They will also retain the publishing rights to the article without any restrictions.
Authors who publish with this journal agree to the following terms:
Any article on the copyright is retained by the author(s).
The author grants the journal, right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share work with an acknowledgment of the work authors and initial publications in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of published articles of work (eg, post-institutional repository) or publish it in a book, with acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their websites) prior to and during the submission process, as can lead to productive exchanges, as well as earlier and greater citation of published work.
The article and any associated published material are distributed under the Creative Commons Attribution-ShareAlike 4.0 International License.
url:https://journal.umpr.ac.id/index.php/bjop/article/view/6743
Array
Substances with hepatoprotective activity can inhibit oxidation to protect the body's cells from the damaging effects of oxidation. It can bind to free oxygen radicals preventing these radicals from damaging healthy cells. The present investigation aims to evaluate the in vivo antioxidant potential of the bark of Anogeissus latifolia in ethanol-induced hepatotoxicity. Animals were treated with the methanol extract of A. latifolia (MEAL) for 15 days and induced oxidative stress with a single dose of ethanol (36 mg/kg po). The activity was measured by measuring oxidative stress markers such as lipid peroxidation, reduced glutathione, superoxide dismutase, and catalase levels in hepatotoxic rats. Administration of MEAL at 100 and 200 mg/kgBW marked decreased ethanol-induced elevation levels of oxidative stress markers and liver in a dose-dependent manner. The effects of the extract were compared with the Silymarin standard at 100 mg/kgBW. In methanol extract-treated animals, the toxic effect of ethanol was controlled significantly (P <0.05) by restoration of the levels of enzymes as compared to the normal and standard groups. The results concluded that the MEAL bark possesses significant in vivo antioxidant activity and can be exploited in protecting hepatic tissue from oxidative stress.