2024-03-29T07:44:53Z
https://journal.umpr.ac.id/index.php/bjop/oai
oai:journal.umpr.ac.id:article/371
2019-12-01T12:06:02Z
bjop:Pharm-Tox
Effect of Giving Celecoxib on Uric Acid Level on Mice
Surya, Sara
Uric Acid
Celecoxib
non-steroidal anti-inflammatory
Pharmacology
Celecoxib is a breakthrough for pain relievers under the trade name Celebrex®, which is a Non-Steroid Anti-Inflammatory drug with its activity as an analgesic, antipyretic and anti-inflammatory. The purpose of this study was to find out the effect of celecoxib on blood uric acid levels of female white mice was induced with fresh cow liver extract. Experimental animals were divided into five groups, namely the control group (-), the control group (+) and the three dose groups, respectively 0.26, 0.52 and 1.04 mg/20 g. Observations were made on 7, 14 and 21 days with the Enzymatic Photometric method. The results showed that administration of celecoxib suspension at a dose of 0.26, 0.52 and 1.04 mg/20 g did not affect blood uric acid levels when compared with controls (P> 0.05).
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2018-11-01
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/371
10.33084/bjop.v1i2.371
Borneo Journal of Pharmacy; Vol. 1 No. 2 (2018): Borneo Journal of Pharmacy; 61-63
2621-4814
10.33084/bjop.v1i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/371/355
Copyright (c) 2018 Sara Surya
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/694
2022-11-09T14:16:41Z
bjop:Pharm-Tox
Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp
Zubaydah, Wa Ode Sitti
Wahyuni, Wahyuni
Sahidin, Sahidin
Halik, Tian Amalia
Andriani, Rina
Indalifiany, Astrid
Fristiohady, Adryan
Gel
Ethanol extract
Xestospongia Sp. sponge
Carrageenan
Anti-inflammatory
Pharmacology
The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2019-05-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/694
10.33084/bjop.v2i1.694
Borneo Journal of Pharmacy; Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy; 1-9
2621-4814
10.33084/bjop.v2i1
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/694/663
Copyright (c) 2019 Wa Ode Sitti Zubaydah, Wahyuni Wahyuni, Sahidin Sahidin, Tian Amalia Halik, Rina Andriani, Astrid Indalifiany, Adryan Fristiohady
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/707
2022-11-09T14:16:41Z
bjop:Pharm-Tox
Antidiarrheal Activity of Ethanolic Extract of Vernonia amygdalina Del Leaves againts Male Mice Induced by Oleum Ricini
Astuti, Karunita Ika
Wulandari, Lusiana Dwi
Susiani, Eka Fitri
Antidiarrheal
Oleum ricini
Vernonia amygdalina Del. leaves
Pharmacology
Leaves of Vernonia amygdalina Del. is one of the alternative plants that people use as antidiarrheal in Martapura, Banjar. The purpose of research to determine the antidiarrheal activity and the effectiveness of ethanolic extract of leaves against male mice. The negative control was given NaCMC 0.5% orally, positive control was given Loperamide HCl 0.005 mg/20 g orally, and groups of ethanolic extract of leaves were given dosages in 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW orally. After 1 hour of treatment, the groups were induced by Oleum ricini orally and were observed for 4 hours. Based on three parameters were frequency, weight, and consistency of diarrhea. From the results observation of that negative control, positive control, EEDA 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW for diarrhea frequency parameter was 7.4 ± 2.30; 2 ± 1.22; 5.8 ± 3.34; 6.2 ± 4.08; 2.4 ± 1.67; the weight parameter was 1.34 ± 0.43; 0.38 ± 0.29;0.66 ± 0.56; 0.57 ± 0.38; 0.49 ± 0.33 and then consistency of diarrhea with EEDA 400 mg/kg BW improved the consistency at 180 minutes compared to control group at 210 minutes. In conclusion, from all parameters of ethanolic extract of Vernonia amygdalina Del. leaves can give an antidiarrhea effect with optimum dosage is 400 mg/kg BW.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2019-05-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/707
10.33084/bjop.v2i1.707
Borneo Journal of Pharmacy; Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy; 10-14
2621-4814
10.33084/bjop.v2i1
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/707/664
Copyright (c) 2019 Karunita Ika Astuti, Lusiana Dwi Wulandari, Eka Fitri Susiani
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/868
2022-11-11T07:46:41Z
bjop:Pharm-Tox
Immunomodulator Activity of Effervescent Granule of Wualae Fruit (Etlingera elatior (Jack) R.M. Smith) Based on Specific Phagocytic Activity
Fristiohady, Adryan
Zubaydah, Wa Ode Siti
Wahyuni, Wahyuni
Mirda, Mirda
Saripuddin, Saripuddin
Andriani, Rina
Purnama, La Ode Muhammad Julian
Sahidin, Sahidin
Effervescent granule
Wualae fruit
phagocytosis activity
Pharmacology
The previous study reported that Etlingera elatior (Wualae) has activity as immunostimulant with dose at 300 mg/kg BW and 400 mg/kg BW. Formulating natural product into effervescent granule (GE) can increase practicality and interest to consume traditional medicine. This study aims to investigate the immunostimulant activity of Wualae ethanolic extract in the effervescent granule. Wualae was macerated with ethanol then formulated into effervescent granule at dose 300 mg/kgBW and 400 mg/kgBW. Formulations were evaluated. Animals were divided into 4 groups and treated with: group I (positive control); group II (negative control); group III (GE dose at 300mg/kgBW); and group IV (GE at dose 400mg/kgBW) for 7 days and at days 8, groups were infected by Staphylococcus aureus intraperitoneally. Immunostimulant activity was measured by calculating the Specific Phagocytic Activity (SPA) of macrophage. Data collected from the evaluation and measurement of the SPA then analyzed using SPSS. Results from the evaluation were considered good except the moisture content of effervescent granule. Results from SPA was found that effervescent granule at dose 300 mg/kgBW and at dose 400 mg/kgBW have 26.33% and 32.5% consecutively with significance 0.02 (p<0.05). Thus, effervescent granule has comparable phagocytosis activity with positive control.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2019-11-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/868
10.33084/bjop.v2i2.868
Borneo Journal of Pharmacy; Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy; 35-40
2621-4814
10.33084/bjop.v2i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/868/969
Copyright (c) 2019 Adryan Fristiohady, Wa Ode Siti Zubaydah, Wahyuni Wahyuni, Mirda Mirda, Saripuddin Saripuddin, Rina Andriani, La Ode Muhammad Julian Purnama, Sahidin Sahidin
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/982
2022-11-11T07:46:41Z
bjop:Pharm-Tox
Evaluation of Biochemical Parameters of Rats Fed with Corn Flour Supplemented with Cricket (Acheta gossypii) Proteins
Ehoche, Elijah Edache
Helmina, Akanya
Sherifat, Adefolalu Funmilola
diets
supplementation
corn
cricket
Biochemistry
African staple diets are mainly of protein-deficient corn. Dried yellow corn was fermented, dried, ground and supplemented with 5% and 10% of cricket (Acheta gossypii) flour. A standard diet of 5% and 10% soybean proteins-based corn flour was also prepared. The diets were fed to albino rats for four weeks. Standard methods for the serum levels of alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), total proteins (TP), and albumin were determined in albino rats using 5% and 10% soybean supplemented corn diets as standard diets. The serum levels of ALP, AST, ALP, TP, and albumin in the rats fed with cricket supplemented diets were in the range of the normal healthy animals but were significantly different from the cornflour and soybean supplemented diets such that the ALP and AST values of the rats fed on the cornflour significantly decreased over the soybean supplemented and cricket supplemented experimental diets. The ALT activity, TP, and albumin levels of the rats fed the cornflour, and the soybean supplemented diets were significantly lower than those fed on the cricket protein supplemented diet (p <0.05). Supplementing corn with crickets has shown improvement in the nutritional quality of corn, therefore, may be used to solve the malnutrition
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2019-11-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/982
10.33084/bjop.v2i2.982
Borneo Journal of Pharmacy; Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy; 41-47
2621-4814
10.33084/bjop.v2i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/982/976
Copyright (c) 2019 Elijah Edache Ehoche, Akanya Helmina, Adefolalu Funmilola Sherifat
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/1020
2022-11-11T07:46:41Z
bjop:Pharm-Tox
The Potential of Walnut Seeds (Canarium indicum L.) in Repairing The Genotoxicity Effect of Mercury on Mice Erythrocytes
Wibowo, Cakra Haryo
Oktarina, Essy
Wardani, Rafika Destiana
Ngibad, Khoirul
Walnut
Ellagic Acid
Genotoxicity
Mercury
Micronucleus Assay
Toxicology
Hydrargyrum (familiar as mercury) is a persistent transition metal element. They are known as bio-accumulative properties that are dangerous to the environment and has serious damaging effects on biota, including genetic changes or mutagenesis. Moreover, it can accumulate indirectly in the human body due to the consumption of products that have contaminated. Whereas, ellagic acid has reported as one of 13 flavonoid compounds that have potential as an anti-mutagen and anti-cancer in the walnuts seeds. This study was aimed to ensure the potential extent of ellagic acid extracts in walnut seeds to reducing and repairing the genotoxicity effects of mercury. Therefore, using the experimental method, this study was divided into several test treatments. Two controls treatment as a comparison of the presence of micronucleus with group tests that given a 20 ppm mercury dosage. Then continued with the addition of walnut seed extract with various dosage (10, 15, and 20 ppm) by oral injection continuously for two weeks as a recovery process to reducing and repairing the genotoxicity effect of mercury. The significant results showed that there are differences between pre and post-treatment. It indicated that the extract has the potential for improving and reducing the genotoxicity effect of mercury. The data were evaluated and obtained the total micronucleus from the smear of peripheral blood of mice by comparing the total micronucleus before and after giving of walnut extract.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2019-11-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1020
10.33084/bjop.v2i2.1020
Borneo Journal of Pharmacy; Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy; 48-54
2621-4814
10.33084/bjop.v2i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/1020/977
Copyright (c) 2019 Cakra Haryo Wibowo, Essy Oktarina, Rafika Destiana Wardani, Khoirul Ngibad
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/1246
2020-04-15T01:05:25Z
bjop:Pharm-Tox
Effect of Broccoli (Brassica oleracea L. var. italica) Extract on Bleeding Time in Male White Mice (Mus musculus L.)
Sammulia, Suci Fitriani
Almahdy, Almahdy
Rezky, Aldo Wahyu
Bleeding time
Brassica oleracea
Hemostatic
Pharmacology-Toxicology
Cessation of bleeding is influenced by many factors including the type of medication used. The use of drugs to stop bleeding can be done in various ways, one of which is the use of traditional medicine. One of the traditional plants that can be used as a stop bleeding is broccoli (Brassica oleracea L. var. italica) which has a fairly high vitamin K content, where is efficacious as hemostatic. This study aims to determine the effect of broccoli on the bleeding time of mice tail cuts. The first group was negative control (Na-CMC), the second group was positive control (tranexamic acid), while groups three, four, and five were broccoli extract dose of 20, 40, and 60 mg/kg BW, respectively. All treatments were given orally for seven days. Bleeding time was calculated from the initial blood loss until the blood stopped (tail bleeding I method) and the data were analyzed with the ANOVA one way test and the post hoc Least Significant Difference (LSD) statistical test. The results showed that there were differences in the time to stop bleeding in the treatment control group at a dose of 20 mg/kg BW (122.60 ± 29.535 seconds), 40 mg/kg BW (102.40 ± 9.607 seconds) and 60 mg/kg BW (90.40 ± 3.845 seconds). From these results, it can be concluded that the extract of broccoli at a dose of 60 mg/kg BW gives the best results as hemostatic, while the effect is almost similar to the positive control group.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2020-02-27
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
application/xml
https://journal.umpr.ac.id/index.php/bjop/article/view/1246
10.33084/bjop.v3i1.1246
Borneo Journal of Pharmacy; Vol. 3 No. 1 (2020): Borneo Journal of Pharmacy; 1-6
2621-4814
10.33084/bjop.v3i1
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/1246/1119
https://journal.umpr.ac.id/index.php/bjop/article/view/1246/1320
Copyright (c) 2020 Suci Fitriani Sammulia, Almahdy Almahdy, Aldo Wahyu Rezky
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/1318
2020-06-27T14:29:43Z
bjop:Pharm-Tox
Level of Cytokine Interleukin-6 and Interleukin 1-β on Infectious Rat Model Treated with Etlingera elatior (Jack) R.M. Smith Fruit Extract as Immunomodulator
Fristiohady, Adryan
Wahyuni, Wahyuni
Malik, Fadhliyah
Yusuf, Muhammad Ilyas
Salma, Wa Ode
Hamsidi, Rini
Talebong, Fredy
Yuliansyah, Yuliansyah
Purnama, La Ode Muhammad Julian
Saripuddin, Saripuddin
Sahidin, Sahidin
Etlingera elatior (Jack) R.M. Smith
Immunomodulator
Plasma IL-1β
Plasma IL-6
Pharmacology
Etlingera elatior (Jack) R.M Smith or locally in Southeast Sulawesi known as Wualae fruit has activity as an immunomodulator by increasing phagocytosis activity. Prior studies have been conducted to observe the effect of E. elatior as an immunomodulator, thus further study is needed to observe the production of cytokines such as IL-1β and IL-6 which are responsible for the immune responses. Etlingera elatior fruit macerated with 96% ethanol for three days and produced a total of ±74.6 g concentrated extract. Experimental animals used were divided into four groups (n=4) and treated orally once a day for seven days as follows: group I (0.5% Na CMC); group II (Stimuno®); group III (E. elatior fruit extract dose of 300 mg/kg BW); and group IV (E. elatior fruit extract dose of 400 mg/kg BW). On the eight-day, animals were infected with Staphylococcus aureus intraperitoneally and left for an hour. Thereafter, blood was collected and assayed using ELISA Kit (Elabscience rat IL-1β and Elabscience rat IL-6). Results demonstrated that group IV increased levels of IL-1β and group III and IV increased level of IL-6 (p<0.05). Increased levels of IL-1β and IL-6 are associated with phagocytosis in the immune response. In conclusion, E. elatior fruit extract at doses of 300 and 400 mg/kg BW increases levels of IL-1β and IL-6.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2020-05-21
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
application/xml
https://journal.umpr.ac.id/index.php/bjop/article/view/1318
10.33084/bjop.v3i2.1318
Borneo Journal of Pharmacy; Vol. 3 No. 2 (2020): Borneo Journal of Pharmacy; 52-57
2621-4814
10.33084/bjop.v3i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/1318/1230
https://journal.umpr.ac.id/index.php/bjop/article/view/1318/1238
Copyright (c) 2020 Adryan Fristiohady, Wahyuni Wahyuni, Fadhliyah Malik, Muhammad Ilyas Yusuf, Wa Ode Salma, Rini Hamsidi, Fredy Talebong, Yuliansyah Yuliansyah, La Ode Muhammad Julian Purnama, Saripuddin Saripuddin, Sahidin Sahidin
oai:journal.umpr.ac.id:article/1365
2020-09-04T06:23:48Z
bjop:Pharm-Tox
Phytochemical Screening and Anti-Hyperuricemia Activity Test In Vivo of Ethanolic Extract of Shallot (Allium cepa L.) Skin
Syahrina, Syahrina
Asfianti, Vivi
Gurning, Kasta
Iksen, Iksen
Hyperuricemia
Allopurinol
Potassium oxonate
Shallot
Shallot skin
Pharmacology
Uric acid is the final product of purine metabolism that will be excreted through urine, feces, and sweat. Excessive production of uric acid can cause hyperuricemia, known as gout. The skin of shallots (Allium cepa L.) is one of the household wastes that are very rarely used by the community. Ethanol extract of shallot skin (EESS) was tested for phytochemical screening and anti-hyperuricemia activity using potassium oxonate. Mice were divided into five groups (Allopurinol, Na-CMC, EESS 200 mg/kg BW, 300 mg/kg BW, and 400 mg/kg BW) and uric acid levels were observed at 2-hour intervals for six hours. Phytochemical screening shows that EESS has potential compounds in the treatment of gout. Tests to reduce uric acid levels showed that EESS has better potential than allopurinol at concentrations of 300 mg/kg BW and 400 mg/kg BW after six hours of induction in reducing uric acid levels.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2020-08-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1365
10.33084/bjop.v3i3.1365
Borneo Journal of Pharmacy; Vol. 3 No. 3 (2020): Borneo Journal of Pharmacy; 146-151
2621-4814
10.33084/bjop.v3i3
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/1365/1383
https://journal.umpr.ac.id/index.php/bjop/article/view/1365/1401
https://journal.umpr.ac.id/index.php/bjop/article/view/1365/1407
Copyright (c) 2020 Syahrina Syahrina, Vivi Asfianti, Kasta Gurning, Iksen Iksen
oai:journal.umpr.ac.id:article/1569
2020-12-08T00:49:53Z
bjop:Pharm-Tox
Role of Cannabinoid Receptors in Psychological Disorder
Jha, Ambika Nand
Patel, Dhaval M
Endocannabinoid
Neurochemical
CB1 receptors
CB2 receptors
Anxiety
Alzheimer
Pharmacology
Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system. Cannabinoid CB1 and CB2 receptors are G protein-coupled receptors present from the early stages of gestation, which is involved in various physiological processes, including appetite, pain-sensation, mood, and memory. Due to the lipophilic nature of cannabinoids, it was initially thought that these compounds exert several biological effects by disrupting the cell membrane nonspecifically. Recent biochemical and behavioral findings have demonstrated that blockade of CB1 receptors engenders antidepressant-like neurochemical changes (increases in extracellular levels of monoamines in cortical but not subcortical brain regions) and behavioral effects consistent with antidepressant/antistress activity. We aim to define various roles of cannabinoid receptors in modulating signaling pathways and association with several pathophysiological conditions.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2020-11-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1569
10.33084/bjop.v3i4.1569
Borneo Journal of Pharmacy; Vol. 3 No. 4 (2020): Borneo Journal of Pharmacy; 199-208
2621-4814
10.33084/bjop.v3i4
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/1569/1490
https://journal.umpr.ac.id/index.php/bjop/article/view/1569/1773
https://journal.umpr.ac.id/index.php/bjop/article/view/1569/1774
Copyright (c) 2020 Ambika Nand Jha, Dhaval M Patel
oai:journal.umpr.ac.id:article/1703
2021-05-24T14:02:35Z
bjop:Pharm-Tox
Combination of Bawang Dayak Extract and Acarbose against Male White Rat Glucose Levels
Putra, Aditya Maulana Perdana
Sari, Ratih Pratiwi
Musiam, Siska
Acarbose
Bawang dayak
Glucose levels
Pharmacology
Diabetes is a chronic metabolic disease with signs of increased blood glucose levels. Type 2 diabetes is common diabetes in adults. Bawang dayak is one of the plants believed to have the efficacy of curing various types of diseases. The purpose of this study was to find out the comparison of hypoglycemic effects between combinations of bawang dayak extract and acarbose with single acarbose. This study was an experimental study using 32 white mice divided into two groups. Group one was given a combination of bawang dayak at a dose of 100 mg/kg BW and acarbose at a dose of 40 mg/100 g BW, while group two was given acarbose at a dose of 40 mg/100 g BW. Treatment is administered after the test animal is induced with dexamethasone at a 1 mg/kg BW dose dissolved in NaCl 0.9% subcutaneously for 12 days. Measurement of glucose levels was carried out using a glucometer. Data retrieval was carried out every three days for 15 days after previously fulfilled for +10 hours. Blood glucose level data were analyzed with the General Linear Model test. The combination of bawang dayak-acarbose onion extract had a greater decrease in blood glucose levels than single acarbose. Average reduction in blood glucose levels for D+3; D+6; D+9; D+12; and D+15 was 187.31; 168.56; 140.81; 119.81; and 102.56 mg/dl, respectively. The General Linear Model test results showed a p <0.05 value that significantly impacted blood glucose levels between groups.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-05-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1703
10.33084/bjop.v4i2.1703
Borneo Journal of Pharmacy; Vol. 4 No. 2 (2021): Borneo Journal of Pharmacy; 84-90
2621-4814
10.33084/bjop.v4i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/1703/1727
https://journal.umpr.ac.id/index.php/bjop/article/view/1703/1764
https://journal.umpr.ac.id/index.php/bjop/article/view/1703/1743
Copyright (c) 2021 Aditya Maulana Perdana Putra, Ratih Pratiwi Sari, Siska Musiam
oai:journal.umpr.ac.id:article/1782
2021-05-24T14:02:32Z
bjop:Pharm-Tox
In Vitro Determination of Sun Protection Factor of Water Extract of Aerodramus fuciphagus from Central Kalimantan
Sandi, Dita Ayulia Dwi
Susiani, Eka Fitri
Adnyana, I Ketut
Wikaningtyas, Pratiwi
Sunscreen
Edible-nest swiftlet's Nest
Erythema transmission
Sun Protection Factor
Pigmentation transmission
Aerodramus fuciphagus
Pharmacology
Sunscreen is a cosmetic substance that has the ability to reflect or absorb sunlight actively. It can prevent skin irritation due to UV rays. One of the natural ingredients with a sunscreen effect is the Edible-nest swiftlet's (Aerodramus fuciphagus) nest (ESN). This study aimed to determine the value of the sun protective factor (SPF) of the ESN water extract. The ESN water extract solution with variation concentration, this is 2000, 2500, 5000, 6000, and 7000 ppm, were measured by spectrophotometric UV-Vis at wavelength 290-375 nm with 5 nm intervals to determine the value of SPF, percentage of erythema transmission (%Te), and percentage of pigmentation transmission (%Tp) of ESN water extract. The result showed that the ESN water extract's SPF values at the concentration 2000, 2500, 5000, 6000, and 7000 ppm were 7.80; 9.68; 18.75; 20.58; and 22.24. The value of %Te of each concentration were 15.60±0.19; 10.03±0.42; 1.24±0.04; 0.81±0.01 and 0.56±0.01. While the value of %Tp of each concentration was showed the sunblock category. In conclusion, the ESN water extract from Central Kalimantan at the concentration of 6000 ppm has potential in ultraviolet protection against the skin in the ultra category with sunblock category mechanism. Further, it can be developed into sunscreen cosmetics from natural ingredients.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-05-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1782
10.33084/bjop.v4i2.1782
Borneo Journal of Pharmacy; Vol. 4 No. 2 (2021): Borneo Journal of Pharmacy; 78-83
2621-4814
10.33084/bjop.v4i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/1782/1717
https://journal.umpr.ac.id/index.php/bjop/article/view/1782/1763
https://journal.umpr.ac.id/index.php/bjop/article/view/1782/1742
Copyright (c) 2021 Dita Ayulia Dwi Sandi, Eka Fitri Susiani, I Ketut Adnyana, Pratiwi Wikaningtyas
oai:journal.umpr.ac.id:article/1916
2021-09-15T08:41:30Z
bjop:Pharm-Tox
Antiasthma Activities of Moringa oleifera Lam. Leaves Extract on the Eosinophil Count and Mast Cells in BALB/c Mice
Palupi, Dian Arsanti
Prasetyowati, Tri Wahyuni
Murtiningsih, Dwi
Mahdiyah, Dede
Asthma
Eosinophil
Moringa oleifera
Toxicology
Asthma is a chronic inflammation of the respiratory tract. This study aimed to prove Moringa oleifera Lam. leaves extract's effect on reducing the eosinophil count and mast cells in asthmatic mice. Twenty BALB/c mice that met the inclusion criteria were divided into four groups of standard control (K1), negative control (K2), dexamethasone (K3), and M. oleifera leaves extract (K4). On days 0 and 7, intraperitoneal ovalbumin (OVA) was sensitized. On days 14, 16, and 18, mice were re-sensitized by inhalation using 1% OVA in sterile 0.9% NaCl. On days 18 to 25, K1 and K2 groups were given Na-CMC, the K3 group was given dexamethasone 1.3 µg/day, and the K4 group was given M. oleifera leaves extract 3.9 mg/day. On the 25th day, the mice were terminated to analyze the eosinophil count and stable bronchiolar mast cells. In conclusion, M. oleifera leaves extract was proven to decrease the eosinophil count with a p-value <0.05 and could stabilize bronchiolar mast cells with a p-value <0.05.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-08-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1916
10.33084/bjop.v4i3.1916
Borneo Journal of Pharmacy; Vol. 4 No. 3 (2021): Borneo Journal of Pharmacy; 171-177
2621-4814
10.33084/bjop.v4i3
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/1916/1931
https://journal.umpr.ac.id/index.php/bjop/article/view/1916/2050
https://journal.umpr.ac.id/index.php/bjop/article/view/1916/1932
Copyright (c) 2021 Dian Arsanti Palupi, Tri Wahyuni Prasetyowati, Dwi Murtiningsih, Dede Mahdiyah
oai:journal.umpr.ac.id:article/1950
2021-05-24T14:02:13Z
bjop:Pharm-Tox
Systemic Lupus Erythematosus Disease: An Overview of the Clinical Approach to Pathogenesis, Diagnosis, and Treatment
Nimesh, Saurabh
Ahmad, Md. Iftekhar
Dhama, Shikhka
Kumar, Pradeep
Akram, Muhammad
Hasaroeih, Neda Esmaeili Nejad
Systemic Lupus Erythematosus
Autoimmune disease
Inflammatory disorder
Pharmacology
The systemic lupus erythematosus (SLE), commonly known as Lupus, is a rare and complex multisystem autoimmune disease where one’s immune system is overactive, and the body attacks its organ systems. SLE is a historically old disease described already in antiquity; it is an example of a chronic disease with physical, psychological, financial, and social implications for individuals diagnosed. It has inspired medical and basic biological scientists that focus on molecular biology, basic immunology, immunopathology, clinical science, genetics, and epidemiology. The syndrome is real in its existence-although hidden behind obstacles, cumbersome for patients and clinicians, and rebellious for scientists. There is currently no cure for SLE. The goal of treatment is to ease symptoms. This article will review information on the general approach to SLE therapy, focusing on currently approved therapies and novel approaches that might be used in the future.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2021-05-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
application/xml
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/1950
10.33084/bjop.v4i2.1950
Borneo Journal of Pharmacy; Vol. 4 No. 2 (2021): Borneo Journal of Pharmacy; 91-98
2621-4814
10.33084/bjop.v4i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/1950/1728
https://journal.umpr.ac.id/index.php/bjop/article/view/1950/1765
https://journal.umpr.ac.id/index.php/bjop/article/view/1950/1747
Copyright (c) 2021 Saurabh Nimesh, Md. Iftekhar Ahmad, Shikhka Dhama, Pradeep Kumar, Muhammad Akram, Neda Esmaeili Nejad Hasaroeih
oai:journal.umpr.ac.id:article/2099
2023-05-25T03:53:13Z
bjop:Pharm-Tox
Acute Toxicity of Self-Nanoemulsifying Drug Delivery System of Ipomoea reptans Poir Leaves Extract on Female Wistar Rats
Putri, Cynthia Astiti
Hayati, Farida
Chabib, Lutfi
Pangestu, Muhammad Iqbal
SNEDDS
Ipomoea reptans leaves
OECD 423
LD50
Acute toxicity
Ipomoea reptans Poir has many health benefits, such as decreasing blood glucose and as an antioxidant. Self-nano emulsifying drug delivery systems (SNEDDS) are an innovation in pharmaceutical technology that minimizes drug molecules and maximizes surface area, thus increasing drug absorption. This study aimed to investigate SNEDDS of I. reptans acute toxicity in female Wistar rats. An acute toxicity test was done using a limit test of OECD 423. Female Wistar rats were divided into control and treatment groups, with three animals for each group being used per step. No animals died after they were given SNEDDS of I. reptans leaves extract at a dose of 2000 mg/kg. No toxic effect was detected at clinical examination and histopathology of the organ. SNEDDS of I. reptans leaves extract had an LD50 cut-off value of 5000 mg/kg.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-02-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/2099
10.33084/bjop.v6i1.2099
Borneo Journal of Pharmacy; Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy; 1-7
2621-4814
10.33084/bjop.v6i1
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/2099/3069
Copyright (c) 2023 Cynthia Astiti Putri, Farida Hayati, Lutfi Chabib, Muhammad Iqbal Pangestu
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/2822
2022-12-17T14:09:42Z
bjop:Pharm-Tox
Antiproliferative Potency of God’s Crown Fruit (Phaleria macrocarpa) Extract Against Breast Cancer Cell
Hasim, Hasim
Mantik, Yonathan Arderian
Husnawati, Husnawati
Priosoeryanto, Bambang Pontjo
Puspita, Ratna
Antiproliferation
MCF-7 cell
breast cancer
Herb
God’s Crown Fruit
Breast cancer is a sickness caused by abnormal cell growth in the breast. Mahkota Dewa fruit or god’s crown fruit products (Phaleria macrocarpa) contain flavonoids, alkaloids, polyphenols, and tannins associated with active compounds. This work directs to influence the potency of P. macrocarpa fruit as an antiproliferative agent against breast cancer cells (MCF-7 cells). The antiproliferative potency of P. macrocarpa fruit was proved by extracting and fractionating P. macrocarpa fruit using maceration. The cytotoxicity of extracts and fractions was determined using Brine Shrimp Lethality Test (BSLT). The antiproliferative potency against MCF-7 cells was tested using the hemacytometer approach. This work demonstrates the crude ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction. The LC50 values in crude ethanol extract, n-hexane fraction, ethyl acetate fraction, and water fraction were 13.72 ppm, 147.55 ppm, 405.81 ppm, and 149. 07 ppm severally. Phaleria macrocarpa fruit has shown antiproliferation potency against MCF-7 cells. The maximum part of crude ethanol extract antiproliferative potency (56 ppm) effectively suppressed MCF-7 cell growth by 70. 9% while doxorubicin (100 ppm) by 46. 92%. This work confirms that crude ethanol extract of P. macrocarpa fruit interacts synergistically as an antiproliferative compound against MCF-7 cells.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-11-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
text/xml
https://journal.umpr.ac.id/index.php/bjop/article/view/2822
10.33084/bjop.v5i4.2822
Borneo Journal of Pharmacy; Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy; 307-314
2621-4814
10.33084/bjop.v5i4
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/2822/2790
https://journal.umpr.ac.id/index.php/bjop/article/view/2822/2983
Copyright (c) 2022 Hasim Hasim, Yonathan Arderian Mantik, Husnawati Husnawati, Bambang Pontjo Priosoeryanto, Ratna Puspita
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/3169
2022-07-20T09:01:34Z
bjop:Pharm-Tox
Anti-Inflammatory and Analgesic Activity of Musa balbisiana Peels In Vivo
Sandhiutami, Ni Made Dwi
Khairani, Sondang
Dewi, Rika Sari
Hakim, Zainur Rahman
Pradani, Anita Rahmi
Anti-Inflammatory
Analgesic
Musa balbisiana peels
Phytochemia pharmacology
Musa balbisiana Peels (MBP) contains high levels of flavonoids, alkaloids, tannins, saponins, and triterpenoids. Flavonoids function to slow down the inflammatory process by inhibiting the arachidonic acid, forming prostaglandins, and releasing histamine. This study aimed to examine the anti-inflammatory and analgesic effects of MBP decoction. This study used the Winter method for anti-inflammatory assay by induction of carrageenan on the soles of rat's feet and Sigmund's method for analgesic assay with intraperitoneal induction of acetic acid in mice. Group I as a negative control, group II as a positive control with diclofenac sodium, group III as a low dose (200 mg/kg BW of MBP), group IV as a medium dose (400 mg/kg BW of MBP), and group V as a high dose (800 mg/kg BW of MBP decoction). The percentage of inhibition in the anti-inflammatory test in rats for groups II, III, IV, and V was 34.43%, 17.68%, 25.53%, and 25.4%, and the percentage of effectiveness for the anti-inflammatory test, respectively, was 51.35%, 74.15%, and 74.01%. The results of the percentage inhibition of the analgesic test in mice for groups II, III, IV, and V were 55.25%, 38.52%, 44.53%, and 49.31%, and the percentage of effectiveness for the analgesic test, respectively, followed by 69.71%, 80.59%, and 89.24%. Based on the results, it can be concluded that the decoction of the MBP has an anti-inflammatory and analgesic effect.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2022-05-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
application/xml
https://journal.umpr.ac.id/index.php/bjop/article/view/3169
10.33084/bjop.v5i2.3169
Borneo Journal of Pharmacy; Vol. 5 No. 2 (2022): Borneo Journal of Pharmacy; 81-92
2621-4814
10.33084/bjop.v5i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/3169/2478
https://journal.umpr.ac.id/index.php/bjop/article/view/3169/2737
Copyright (c) 2022 Ni Made Dwi Sandhiutami, Sondang Khairani, Rika Sari Dewi, Zainur Rahman Hakim, Anita Rahmi Pradani
oai:journal.umpr.ac.id:article/3499
2023-05-25T03:53:13Z
bjop:Pharm-Tox
Cytotoxic Activity of Ethyl Acetate Extract from Voacanga foetida (Bl.) Rolfe Leaves Against T47D Breast Cancer Cells
Susanty, Adriani
Febrina, Mira
Putri, Dian Sanita
Ikhtiarudin, Ihsan
Wahyuni, Fatma Sri
Dachriyanus, Dachriyanus
Breast Cancer
Cytotoxic
MTT Assay
Voacanga foetida
Tampa Badak
The cytotoxicity of ethyl acetate extract from Tampa badak (Voacanga foetida (Bl.) Rolfe) leaves against Artemia salina leach larvae was determined using the brine shrimp lethality test (BSLT) method and was evaluated against T47D breast cancer cells using MTT assay method. The result of BSLT showed a consistent result with MTT assay, which is the result obtained that ethyl acetate extract is very toxic against A. salina Leach larvae with LC50 value of 8.61 µg/mL and very cytotoxic against T47D breast cancer cells with IC50 values of 0.87; 0.66; and 0.95 µg/mL at the 24, 48 and 72 hours of incubation times, respectively. The MTT assay data were analyzed using a two-way ANOVA statistical method to see the effect of the dependent variable (concentration and time) on the independent variable (% viability). Based on the statistical test result, there is a difference in % viability between concentrations of 0.1; 1; and 10 µg/mL (p <0.05), but the length of incubation does not affect % viability (p >0.05).
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-02-28
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/3499
10.33084/bjop.v6i1.3499
Borneo Journal of Pharmacy; Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy; 8-14
2621-4814
10.33084/bjop.v6i1
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/3499/3102
Copyright (c) 2023 Adriani Susanty, Mira Febrina, Dian Sanita Putri, Ihsan Ikhtiarudin, Fatma Sri Wahyuni, Dachriyanus Dachriyanus
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/4217
2023-08-14T09:00:35Z
bjop:Pharm-Tox
Identification of Biological Risk Genes and Candidate Drugs for Psoriasis Vulgaris by Utilizing the Genomic Information
Niarisessa, Lisza
Puspitaningrum, Anisa Nova
Afief, Arief Rahman
Perwitasari, Dyah Aryani
Adikusuma, Wirawan
Cheung, Rocky
Septama, Abdi Wira
Irham, Lalu Muhammad
Psoriasis vulgaris
Autoimmune Disease
Drug repurposing
Genomic Variant
Psoriasis is an autoimmune disease that causes inflammation on the skin's surface, characterized by the appearance of pink plaques covered with white scales. Currently, the availability of psoriasis vulgaris therapy is still limited. Therefore, considering the discovery of new drug candidates by utilizing genetic variations, such as single nucleotide polymorphisms (SNP) through drug repurposing, is a profitable method. The SNP associated with psoriasis was obtained from Genome-Wide Association Studies (GWAS) and Phenom-Wide Association Studies (PheWAS) databases. We identified 245 SNPs associated with psoriasis vulgaris with criteria of r2 >0.8. To prioritize the candidate of a gene associated with psoriasis, we used five criteria of functional annotation (missense/nonsense, cis-eQTL, PPI, KEGG, and KO mice) where if there were more than two criteria of assessment, they were defined as the risk gene of psoriasis vulgaris. Fifty-two genes were identified as the risk gene of psoriasis vulgaris, then expanded using the STRING database to obtain more gene candidates of drug targets. The result is 104 genes candidates for drug targets, of which 24 overlapped with 96 drugs, according to DrugBank. Of the 96 drugs that have been approved for other indications, we found that five drugs (ustekinumab, tildrakizumab, risankizumab, guselkumab, and etanercept) are currently in clinical trials for the treatment of psoriasis that target two genes (IL23A and TNF). We argue that these two genes are the most promising targets based on their high target scores on functional annotations. This research explains the potential that utilizing genomic variation can contribute to drug discovery.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-05-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/4217
10.33084/bjop.v6i2.4217
Borneo Journal of Pharmacy; Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy; 110-119
2621-4814
10.33084/bjop.v6i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/4217/3253
Copyright (c) 2023 Lisza Niarisessa, Anisa Nova Puspitaningrum, Arief Rahman Afief, Dyah Aryani Perwitasari, Wirawan Adikusuma, Rocky Cheung, Abdi Wira Septama, Lalu Muhammad Irham
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/4387
2023-08-14T09:00:35Z
bjop:Pharm-Tox
The Effect of Long Exposure Reed Diffuser Essential Oil Plumeria alba on Cortisol Levels of Male Wistar Rats
Siska, Siska
Bariroh, Tahyatul
Supandi, Supandi
Aromatherapy
Cortisol
Reed diffuser
Frangipani
Stress
Stress can occur due to a person's inability to respond to a stressor, resulting in bodily or mental disorders. Anxiety can be characterized by increased levels of cortisol, which is regulated by the Hypothalamus-Pituitary-Adrenaline (HPA-axis). Aromatherapy is a therapy using essential oils that give a distinctive aroma to plant parts such as flowers, roots, leaves, and stems. Aromatherapy can be done through a reed diffuser. The frangipani (Plumeria alba) is one of the plants in Indonesia that has a particular scent in its flowers. This study aims to determine the effect of prolonged exposure to P. alba essential oil reed diffuser on cortisol levels in rats. Twenty-four rats were divided into four groups: the control group without exposure to a reed diffuser for 5 and 10 days and the other group with exposure for 5 and 10 days. Each blood was drawn through the retro-orbital, centrifuged to obtain serum, and tested using LC-MS to determine cortisol levels. The group with ten days of essential oil exposure showed lower cortisol levels. It can be concluded that the duration of aromatherapy exposure is connected to cortisol levels and that aromatherapy can be utilized as a stress-reduction therapy.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-05-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/4387
10.33084/bjop.v6i2.4387
Borneo Journal of Pharmacy; Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy; 120-124
2621-4814
10.33084/bjop.v6i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/4387/3348
Copyright (c) 2023 Siska Siska, Tahyatul Bariroh, Supandi Supandi
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/4411
2024-03-13T03:22:19Z
bjop:Pharm-Tox
Iron-Overload Conditions: Manifestations to the Kidney Organs – A Review
Heriatmo, Nadia Larasinta
Estuningtyas, Ari
Soetikno, Vivian
hemosiderosis
transfusion
iron deposits
ferritin
ROS
Excess iron is a risk factor for organ dysfunction and damage resulting in various organ diseases such as liver, heart, and kidney, diabetes mellitus, and neurodegenerative diseases. Iron overload in some individuals is caused by various factors, including genetic predisposition such as genetic hemochromatosis, repeated transfusion of red blood cells, and parenteral iron administration in conditions of transfusion-dependent anemia. A disturbance in the globin gene in diseases such as β-thalassemia major causes an imbalance of the globin chain, resulting in chronic anemia in the sufferer. It has been reported that the human body does not have a mechanism for eliminating excess iron levels. Routine transfusion has become a solution to overcome chronic anemia so that patients can maintain hemoglobin levels, and the result of this transfusion repetition is the accumulation of iron in various organs, such as the heart, liver, endocrine glands, pancreas, lungs, and kidneys. Excess iron can be toxic to the body due to the formation of harmful free radicals that can damage cells and tissues. An increase in excessive ROS can result in the saturation of the antioxidant system. The presence of free radicals can lead to damage and the occurrence of filtration dysfunction in the glomerulus.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-11-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/4411
10.33084/bjop.v6i4.4411
Borneo Journal of Pharmacy; Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy; 360-369
2621-4814
10.33084/bjop.v6i4
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/4411/3780
Copyright (c) 2023 Nadia Larasinta Heriatmo, Ari Estuningtyas, Vivian Soetikno
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/4696
2023-08-14T09:00:35Z
bjop:Pharm-Tox
Phytochemical Analysis and Anti-Inflammatory Activity of The Combination of Trigona apicalis propolis Extract and Honey
Kustiawan, Paula Mariana
Luthfi M, Chaerul Fadly Mochtar
Dewi, Sinta Ratna
Pratiwi, Jati
Aisyiyah, Novia Misnawati
Nugraha, Alfin Syahrian Dwi
Setiawan, Irfan Muris
Inflammatory
Propolis
Combination
In vivo
East Kalimantan
Chronic inflammation is common in infectious diseases, rheumatoid arthritis, gout, and autoimmune diseases. However, using non-steroidal anti-inflammatory drugs (NSAIDs) is accompanied by dangerous side effects. Therefore, searching for safer alternative therapies without side effects is very important. A natural blend of ingredients produced by stingless bees from plants was potential as a remedy. Meanwhile, the potential of kelulut bee products from East Kalimantan as an anti-inflammatory is still unknown. This study aimed to compare the chemical composition of kelulut bee (Trigona apicalis) products and evaluate the anti-inflammatory effect of honey, propolis, and their combination. Propolis extract and honey were determined as secondary metabolites. An anti-inflammatory in vivo assay triggered the edema using carrageenan on male mice and measured its anti-inflammatory power value. Propolis extract and honey from T. apicalis have a promising anti-inflammatory effect and are significantly higher than the positive control. Meanwhile, combining propolis extract and honey did not enhance the anti-inflammatory effect. In addition, combining honey and propolis preparations with a ratio of 75 : 25 has a better effect on reducing edema volume than the other two combinations. Still, it is not better than the treatment with propolis extract or honey alone. The content of polyphenol compounds found in honey and propolis preparations is thought to have an important role in reducing edema volume.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-05-31
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/4696
10.33084/bjop.v6i2.4696
Borneo Journal of Pharmacy; Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy; 125-132
2621-4814
10.33084/bjop.v6i2
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/4696/3357
Copyright (c) 2023 Paula Mariana Kustiawan, Chaerul Fadly Mochtar Luthfi M, Sinta Ratna Dewi, Jati Pratiwi, Novia Misnawati Aisyiyah, Alfin Syahrian Dwi Nugraha, Irfan Muris Setiawan
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/4704
2024-03-13T03:22:19Z
bjop:Pharm-Tox
Anti-Rheumatoid Arthritis Activity of 96% Ethanol Extract of Eleutherine bulbosa Bulbs with Arthritis Induction Adjuvant Method
Muthia, Rahmi
Wati, Helmina
Jamaludin, Wahyudin Bin
Kartini, Kartini
Setiawan, Finna
Zanirah, Gina Rizki
inflammation
autoimmune
complete freund’s adjuvant
An autoimmune condition known as rheumatoid arthritis (RA) results in chronic joint inflammation. Side effects that occur during long-term RA treatment are dangerous. Therefore, many people prefer herbal medicines, estimated to have lower side effects; one such herb is bawang dayak (Eleutherine bulbosa Urb.) bulbs. This study aimed to determine the class of compounds and the effective dose of the 96% ethanol extract of E. bulbosa bulbs, which had an anti-RA effect in the Wistar strain with the Adjuvant Induced Arthritis (AIA) model. Eleutherine bulbosa bulb extract was macerated with 96% ethanol. In the tests with extract doses of 100, 200, and 400 mg/KgBW and methylprednisolone 15 mg/KgBW, the induction used Complete Freund's Adjuvant (CFA). Treatment was provided from day eight through 21 of the test's 21-day duration. Phytochemical screening results contain alkaloids, flavonoids, phenols, quinones, saponins, steroids, and tannins. The percentage inhibition of edema volume and joint thickness, respectively, extract doses of 100, 200, 400 mg/KgBW, and methylprednisolone 15 mg/KgBW were 27.9585%, 49.3446%, 53.3239%, and 58.4629%; as well as 64.9809%, 73.8022%, 74.1444%, and 74.1825%. After analyzing the results, it was determined that E. bulbosa bulb extracts in 96% ethanol can treat RA at effective 200 and 400 mg/KgBW (p-value <0.05).
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-11-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/4704
10.33084/bjop.v6i4.4704
Borneo Journal of Pharmacy; Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy; 370-378
2621-4814
10.33084/bjop.v6i4
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/4704/3847
Copyright (c) 2023 Rahmi Muthia, Helmina Wati, Wahyudin Bin Jamaludin, Kartini Kartini, Finna Setiawan, Gina Rizki Zanirah
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/5217
2024-03-13T03:22:19Z
bjop:Pharm-Tox
Diuretic Activity of Various Herbs in India: A Mini Review
Shaikh, Sufiyan Yusuf
Shaikh, Aftab Tanveer
Shaikh, Moinuddin Arif
Diuretics
Herbal
India
One of the primary uses of medicinal plants is as a diuretic. Both mono- and polyherbal-based diuretic formulations have been used in various parts of the world, including in India. One estimate states that more than 650 mono- and polyherbal formulations are in clinical use, including decoctions, tinctures, pills, and capsules made from over 75 plants. Many studies have been conducted supporting the diuretic properties of conventional herbal remedies. This article discusses many herbal plants from India that have historically been used as diuretics and identifies the chemical components with diuretic activity. In addition, this brief review also discusses several plant drugs and their pharmacological profile, concentrating on the administered dose and the bioactive extracts involved in the diuresis process. For researchers, searching for the best therapeutic plants for diuretic research may be a significant turning point in using various herbs from India.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-11-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/5217
10.33084/bjop.v6i4.5217
Borneo Journal of Pharmacy; Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy; 349-359
2621-4814
10.33084/bjop.v6i4
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/5217/3774
Copyright (c) 2023 Sufiyan Yusuf Shaikh, Aftab Tanveer Shaikh, Moinuddin Arif Shaikh
https://creativecommons.org/licenses/by-sa/4.0
oai:journal.umpr.ac.id:article/5351
2023-11-09T08:03:08Z
bjop:Pharm-Tox
Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice
Dibal, Nathan Isaac
Goni, Zainab Muhammad
Attah, Martha Orendu Oche
Imam, Umar
Abdullahi, Muhammad
Bashir, Muzammil
Adam, Usman
Aisami, Fatima
Shuwa, Mohammed
Manye, Sunday Joseph
Gadzama, Madu Nom
Chiroma, Musa Samaila
Ishaya, Helga Bedan
Hyperglycemia
Lymphoid cells
Aloe vera
Testicles
Pancreatic islet
High-fat diet alone or in combination with high fructose has been known to induce diabetes, obesity, hypertension, and immune dysfunction. The study evaluates the role of Aloe vera in fat-rich and high fructose diet-induced (FRHFD) hyperglycemias in addition to testicular and splenic morphology in mice. Twenty BALB/c Mice were randomly distributed into four groups (n=5). The groups were fed on a normal diet, FRHFD, FRHFD + 10 g A. vera, and FRHFD + 20 g A. vera for 10 weeks. All the mice were sacrificed a day after the 10 weeks of treatment. The result showed that mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. The mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. Aloe vera was found to ameliorate FRHFD-induced pancreatic islet and acini damage. It also prevented distorted lymphoid cells and testicular damage induced by FRHFD. Aloe vera prevents hyperglycemia and protects pancreatic islets in FRHFD-fed mice. It further prevents immune dysfunction and protects against testicular damage. Hence, A. vera supplementation could be an alternative and/or complementary therapy for hyperglycemia-related disorders.
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya
2023-08-30
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
text
application/pdf
https://journal.umpr.ac.id/index.php/bjop/article/view/5351
10.33084/bjop.v6i3.5351
Borneo Journal of Pharmacy; Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy; 222-228
2621-4814
10.33084/bjop.v6i3
eng
https://journal.umpr.ac.id/index.php/bjop/article/view/5351/3505
Copyright (c) 2023 Nathan Isaac Dibal, Zainab Muhammad Goni, Martha Orendu Oche Attah, Umar Imam, Muhammad Abdullahi, Muzammil Bashir, Usman Adam, Fatima Aisami, Mohammed Shuwa, Sunday Manye, Madu Nom Gadzama, Musa Samaila Chiroma, Helga Bedan Ishaya
https://creativecommons.org/licenses/by-sa/4.0