Profil Penggunaan Obat Kombinasi Risperidone-Clozapine dan Risperidone dengan Antipsikotik Lain pada Pasien Gangguan Mental Psikotik di Rumah Sakit Jiwa Grhasia Yogyakarta

Profile of the Use of Risperidone-Clozapine and Risperidone Combination with Other Antipsychotics in Psychotic Mental Disorders Patients in Grhasia Mental Hospital Yogyakarta

Keywords: Psychotic mental disorder, Risperidone-clozapine, Risperidone, other antipsychotics

Abstract

Approximately 7% of Indonesia's population experience mental disorders psychosis. Yogyakarta Special Region is the second-highest incidence of psychotic mental disorders with a rate of 10 per 1000 population and 80% of those treated in mental hospitals with schizophrenia. Pharmacotherapy management in patients with psychotic mental disorders with the use of antipsychotics, both single and combination. Antipsychotics are classified as atypical antipsychotics and typical antipsychotics. Both groups of antipsychotics have the same pharmacological activity, namely blocking dopamine D2 receptors. The study design is prospective. Inclusion criteria for adult patients (18-65 years), who are inpatient, get risperidone-clozapine antipsychotic therapy and risperidone with other antipsychotics and have complete data. Data obtained from medical records and analyzed with univariate tests to describe the distribution of patients. Bivariate testing to compare the two treatment groups. The number of samples at the end of the study were 32 patients who were divided into 2 groups of antipsychotic antipsychotics, risperidone-clozapine, and risperidone with other antipsychotics. The results of this study show that the therapeutic group that is often used is the combination of risperidone-clozapine compared to risperidone with other antipsychotics in patients with psychotic mental disorders at Yogyakarta Grhasia Mental Hospital.

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References

Keliat, A.B., 2014, Keperawatan Kesehatan Jiwa Kominitas. EGC: Jakarta.
Raune, D, Kuipers, E, Bebbington, PE, 2004. Expressed Emotion at First-Episode Psychosis: Investigating a Carer Appraisal Model. British Journal of Psychiatry, 184, 321-326
Sadock, B.J., Sadock, V.A. & Ruiz, P., 2015, Kaplan & Sadock's Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry. 11th penyunt. Philadelphia: Wolters Kluwer.
World Health Organization (WHO), 2016, Prevalence of Schyzofrenia Report 2016, Switzerland.
Departemen Kesehatan Republik Indonesia., 2018, Riset Kesehatan Dasar (Riskesdas) 2018, Jakarta: Departemen Kesehatan RI.
Yulianty, M.D, Noor Cahaya, Valentina Meta, S., 2017, Studi Penggunaan Antispikotik dan Efek Samping Pada Pasien Skizofrenia di Rumah Sakit Jiwa Sambang Lihum Kalimantan Selatan, Program Studi Farmasi Universitas Lambung Mangkurat, Jurnal Sains Farmasi dan Klinis, Vol 03. No 02.
Cherrie,G., David, C., Frances, D.,Verity, H., Assen, J., Eóin, K., Jayashri, k., Patrick, McG., Olav, N., Nga, T., 2016, Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders. Australian & New Zealand Journal of Psychiatry, 50(5), 410-472.
Permatasari, V.D., 2016, Pola Penggunaan Antispikotik Pada Pasien Skizofrenia di Instalasi Rawat Inap Rumah Sakit Jiwa Grhasia Yogyakarta Tahun 2014, Skripsi, Universitas Gadjah Mada, 2016, Indonesia.
Chisholm-Burns, M. A. et al., 2016, Pharmacotherapy Principles & Practice Fourth Edition. New York: McGraw-Hill Education. 10. Bruijnzeel, D., Uma, S., Rajiv, T. 2014. Antipsychotic treatment of schizophrenia: An Update. Asian Journal of Psychiatry, 635 p: 1-5.
Sthal, S.M., 2013, Sthal Essensial Psychopharmacology, Fourth Edition, 79-128, Cabridge University Press, New York.
Katzung B.G., Masters S.B., et al., 2012, Basic & Clinical Pharmacology Twelfth Edition. United States: The McGraw-Hill Companies, Inc.
Ravanic, D.B., Dejanovic, S.M., Janjic, V., Jovic, S.D., Milovanovic, D.R., Jakovljevic, V., 2009, Effectiveness of clozapine, haloperidol and chlorpromazine in schizophrenia during a five-year period. Arq Neuropsiquiatr; 67(2):195–202. doi: 10.1590/S0004 -282X2009000200005.
Lacro, J.P., Sanaz Farhadian., et al., 2013, Koda-Kimble & Young’s Applied Therapheutics The Clinical Use Of Drugs 10 Ed. Wolters Kluwer, Philadelphia. 1921-1947.
Huang C.L., Hwang T.J., Chen Y.H., Hsieh M.H., Chen H.H., and Hwu H.G., 2015, Intramuscular olanzapine versus intramuscular haloperidol plus lorazepam for the treatment of acute schizophrenia with agitation: An open-label, randomized controlled trial, J Formos Med Assoc, 2015 May; 114 (5): 438-45. doi: 10.1016 / j.jfma.2015.01.018. Epub 2015 Mar 17.
Marder S.R., Van Putten T., Schatzberg A.F., Nemeroff C.B., 2015, Antipsychotic medications. The American Psychiatric Press Textbook of Psychopharmacology. Washington, DC: American Psychiatric Press p: 247—261.
Medscape., 2019, Drug Interaction Checker, (online), (https://reference.medscape.com/drug-interactionchecker), diakses tanggal 6 November 2019.
Barbui C, Signoretti A, Mule S, Boso M, Cipriani A., 2018, Does the addition of a second antipsychotic drug improve clozapine treatment?, Schizophr Bull; 35 (2) : 458–68. doi: 10.1093/schbul/sbn030.
Syamsudin., 2011, Interaksi Obat Konsep Dasar dan Klinis, Penerbit Universitas Indonesia (UI-Press), Jakarta, Indonesia
Published
2020-02-28
How to Cite
Rissa, M. M., Darmawan, E., & Siwinarni, A. (2020). Profil Penggunaan Obat Kombinasi Risperidone-Clozapine dan Risperidone dengan Antipsikotik Lain pada Pasien Gangguan Mental Psikotik di Rumah Sakit Jiwa Grhasia Yogyakarta. Jurnal Surya Medika (JSM), 5(2), 131-138. https://doi.org/10.33084/jsm.v5i2.1320