Studi Docking Molekular Senyawa Turunan Kuinolin Terhadap Reseptor Estrogen-Α

Study of Molecular Docking of Quinoline Derivative Compounds against Estrogen-A Receptors

Authors

DOI:

https://doi.org/10.33084/jsm.v2i1.215

Keywords:

Docking, ER-alpha, Quinine, Quinoline

Abstract

Estrogen-α (ER-α) is the main target for ER + therapy. Inhibition of ER-α is known to slow the proliferation of ER + breast cancer cells. Quinoline derivatives are known to have anticancer activity by inhibiting several types of receptors. It is not known whether quinoline can inhibit ER-α. This study aims to determine the interaction between ER-α with quinoline derivative compounds. Molecular docking of ER-α showed that quinine gave the most negative bond-free energy and the smallest inhibition constant, respectively -8.73 kcal/mol and 0.398 μM. These results provide predictions that quinine has activity as an ER-α inhibitor and has the potential to be developed in the treatment of ER + breast cancer. However, the affinity shown by quinine was lower than that of 4-hydroxytamoxifen, a potent inhibitor of ER-α.

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Author Biography

Mohammad Rizki Fadhil Pratama, Universitas Muhammadiyah Palangkaraya

References

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Published

2016-08-01

How to Cite

Pratama, M. R. F. (2016). Studi Docking Molekular Senyawa Turunan Kuinolin Terhadap Reseptor Estrogen-Α: Study of Molecular Docking of Quinoline Derivative Compounds against Estrogen-A Receptors. Jurnal Surya Medika (JSM), 2(1), 1–7. https://doi.org/10.33084/jsm.v2i1.215