Optimasi Kombinasi Asam Sitrat dan Asam Tartrat sebagai Zat Pengasam pada Tablet Effervescent Ekstrak Ubi Jalar Ungu (Ipomoea batatas L)

Optimization of the Combination of Citric Acid and Tartaric Acid as an Acidifying Agent in Effervescent Tablets of Purple Sweet Potato Extract (Ipomoea batatas L)

Keywords: Purple sweet potato (Ipomoea batatas L), Citric acid, tartaric acid, Effervescent tablets

Abstract

Purple sweet potato has the content of anthocyanin compounds that are efficacious as antioxidants. To deliver these efficacious compounds, formulations of effervescent tablets are required as antioxidants with a combination of citric acid and tartrate acid to accelerate the solubility of the drug. The research aims to optimize the combination of citric acid and tartrate acid as a sourgent on effervescent tablets of purple sweet potato extract using the simplex lattice design method. The manufacture of tablets using a direct pumping method with effervescent powder evaluation includes flow rate test, silent angle, compressibility, and powder moisture. Evaluation of tablets includes organoleptic tests, uniformity of tablet weight, hardness, fragility, and soluble time of tablets—data analysis using simplex lattice design software design expert version 10. The results of effervescent powder evaluation include a test of flow rate, quiet angle, compressibility, and moisture of powder in each formula that already meets the requirements. The physical evaluation results on the effervescent tablet weight uniformity test on F3, F4, and F5 have met the requirements. The evaluation of tablet hardness F1 and F2 also meet the requirements. The results of the evaluation of fragility and time dissolve tablets have met the requirements of all formulas. The simplex lattice design analysis results obtained F5 as the most optimal formula with a concentration of citric acid 103.25 mg and tartrate acid 44.25 mg. The combination of citric acid and tartaric acid affects the evaluation of hardness, fragility, and time-soluble effervescent tablets of purple sweet potato extract. The optimal concentration based on simplex lattice design analysis was obtained in F5 with a citric acid concentration of 103.25 mg and tartrate acid of 44.25 mg.

Downloads

Download data is not yet available.

References

1. Runtuwene, M.R., & Wewengkang, D. (2016). Uji aktivits antioksidan dan toksisitas ekstrak etanol daun foki sabarati (Solanum torvum). Pharmacon, 5(3), 94-101.
2. Hamid, A.A., Aiyelaagbae, O.O., Usman, L.A., Ameen, O.M & Lawal, A. (2010). Antioxidans : Its medicinal and pharmacological Applications, Vol. 4. no. 8, pp 142-151.
3. Forbes-Hernandez, T. Y., Gasparrini, M., Afrin, S., Cianciosi, D., Gonzales-Paramas, A.M., Santos-Buelga, C., Mezzeti, B., Quiles, J.L., Battino, M.,Giamprieri, F., & Bompadre, S. (2017). Strawberry (cv Romina) methanolic extract and anthocyanin-enriched fraction improve lipid profile and antioxidant status in HepG2 cells. International Journal of Melecular Science, 18 (6).
4. Wahyuningsih, S., Wulandari, L., Wartono, M.W., Munawaroh, H., & Ramelan, A.H. (2017). The effect of Ph and color stability of anthocyanin on food colorant. IOP Conference Series : Materials Science and Engineering, 193 (1).
5. Noval, N., Appriliani, R., & Oktaviannoor, H. (2021). Evaluasi Pengaruh Konsentrasi Pati Biji Cempedak (Artocarpus champeden) sebagai Bahan Pengisi pada Formulasi Tablet Paracetamol. Jurnal Surya Medika (JSM), 6(2), 111-118. https://doi.org/10.33084/jsm.v6i2.2127.
6. Priska, M., Peni, N., Carvallo, L., & Ngapa, Y.D. (2018). Review : antosianin dan pemanfaatannya. Cakra Kimia (Indonesia E-Jurnal of Applied Chemistry). Volume 6 Nomor 2.
7. Safari, A et al. (2019). Ekstraksi dan penentuan antioksidan ekstrak ubi jalar ungu (Ipomoea batatas L.). al-Kimiya, Vol.6, no. 2. (46-51).
8. Tristantini, D., Ismawati, A., Pradana, B. T., & Gabriel, J. (2016). Pengujian Aktivitas Antioksidan Menggunakan Metode DPPH pada Daun Tanjung ( Mimusops elengi L ). Universitas Indonesia, 2.
9. Noval, N., Yuwindry, I., & Syahrina, D. (2019). Phytochemical Screening and Antimicrobial Activity of Bundung Plants Extract by Dilution Method. Jurnal Surya Medika. https://doi.org/10.33084/jsm.v5i1.954.
10. Green, S.C., Noonan, P.K., Sanabria, C., & Peacock, W. F. (2016). Effervescent N-Acetylcysteine Tablets versus Oral Solution N-Acetylcysteine in Fasting Healthy Adults : An Open-Label, Randomized, Singel-Dose, Crossover, Relative Bioavailability Study. Current Therapeutic Research-Clinical and Experimental, 83, 1-7.
11. Saifullah, M., Yusof, Y.A., Chin, N., Le., & Aziz, M.G. (2016). Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets. Powder Technology, 301, 396-404.
12. Anova, I. T., Kamsina, K., & Hermianti, W. (2016). Formulasi perbandingan asam basa serbuk effervescent dari cokelat bubuk. Jurnal Litbang Industri. 6 (2), 99.
13. Anwar, K. (2010). Formulasi sediaan tablet effervescent dari ekstrak kunyit (Curcuma domestica Val.) dengan variasi jumlah asam sitrat dan asam tartrat sebagai sumber asam. Sains dan Terapan Kimia. 4 (2), 168-178.
14. Ansel, H.C. (1989). Pengantar Bentuk Sediaan Farmasi (Terjemahan). Universitas Indonesia Press. Jakarta.
15. Mohrle, R., (1989). Effervescent Tablets, In Lieberman, H.A., Lachman, L., % Schwartz, J.B. (editors), Pharmaceutical Dosage Forms Tablets, Vol. I, 2th Ed, Marcel Dekker Inc 225-255. New York.
16. Bolton, S. (1997). Pharmaecutical statistics : practical and clinical application, 3rd ed, Marcel Dekker Inc. New York.
17. Aprilianto, A. (2011). Optimasi Kombinasi Aspartam- Tropicana Slim® Sebagaipemanis Dalam Formulasi Tablet Effervescent Dari Ekstrak Kelopak Bunga Rosella (Hibiscus Sabdariffa L.) Dengan Metode Simplex Lattice Design. Khazanah, 4(1), 1–8. https://doi.org/10.20885/khazanah.vol4.iss1.art1.
18. Ermawati, D. E., Sulaiman, S., & Purwantini, I. (2017). Optimization Formula of Tumeric (Curcuma longa L.) Extract Chewable with Combination of Mannitol-Lactose as Filler Based on Simplex Lattice Design. JPSCR : Journal of Pharmaceutical Science and Clinical Research, 2(01), 53.
19. Fauzan, HA., (2019). Optimasi Campuran Asam Sitrat dan Asam Tartrat pada Tablet Effervescent Ekstrak Buah Tin (Ficus carica L) dengan Metode Simplex Lattice Design. Universitas Islam Indonesia, Yogyakarta.
20. Septiani, S., Wathoni, N., & Mita, S.R. (2011). Formulasi sediaan masker gel antioksidan dari ekstrak etanol biji belinjo. Fakultas Farmasi. Universitas Padjajaran, 2-4.
21. Mopuri, R., Ganjayi, M., Meriga, B., Koorbanally, N.A., & Islam, M.S. (2018). The effect of ficus carica on the activity of enzymes related to metabolic syndrome. Journal of Food and Drug Analysis, 26 (1), 201-210.
22. Pradana, A.T., et al. (2015). Formulasi floating tablet menggunakan variasi konsentrasi HPMC K100M terhadap kemampuan mengapung dan profil disolusi tablet ranitidine HCl. Jurnal Ilmiah Sains dan Teknologi, 9(1) : 11-21.
23. Patel, H.K., Chauhan, P., Patel, K.N., Patel, B.A., & Patel, P.A. (2012). Formulation and evaluation of effervescent tablets of paracetamol and ibuprofen. International Journal for Pharmaceutical Research Scholars, 1(2), 509-520.
24. Kemenkes RI. (2014). Farmakope Indonesia Edisi V. Direktorat Jenderal Bina Kefarmasian dan Alat Kesehatan. Jakarta.
25. British Pharmacopoeia Volume IV. (2007). The Stationary Office on Behalf of Medicine and Healthcare Products Regulatory Agency (MHRA). England.
26. Noval, N., & Rosyifa, R. (2021). Dispersi Padat untuk Peningkatan Laju Disolusi Natrium Diklofenak dengan Variasi Konsentrasi Polivinil Pirolidon K30. Jurnal Surya Medika (JSM), 6(2), 94-101. https://doi.org/10.33084/jsm.v6i2.2125.
27. Anonim. (2014). Farmakope Indonesia, Edisi V. Departemen Kesehatan Republik Indonesia. Jakarta.
28. Apriyanto, B.H., Rusli, R., Rahmadani, A. (2017). Evaluasi pati umbi talas (Colocasia esculenta Schott) sebagai bahan pengisi pada sediaan tablet Paracetamol. Proceeding of the 5th Mulawarman Pharmaceuticals Conference. Fakultas Farmasi Universitas Mulawarman.
29. BPOM RI. (2014). Peraturan Kepada Badan Pengawas Obat dan Makanan Republik Indonesia Nomor 12 Tahun 2014 Tentang Persyaratan Mutu Obat Tradisional. BPOM RI.
30. Dewi, S. K. (2010). Formulasi Sediaan Tablet Fast Disintegrating Antasida Dengan Starch 1500 Sebagai Bahan Penghancur Dan Laktosa Sebagai Bahan Pengisi. 23.
31. Noval, Noval, Melviani Melviani, Novia Novia, and Dahlia Syahrina. 2020. “Formulasi Dan Evaluasi Sediaan Obat Kumur (Mouthwash) Dari Ekstrak Etanol Tanaman Bundung (Actinoscirpus Grossus) Sebagai Antiseptik Mulut”. Jurnal Surya Medika (JSM) 6 (1), 112-20. https://doi.org/10.33084/jsm.v6i1.1626.
32. Anonim. (2016). The United States Pharmacopeia. 39-The National Formulary 34.
33. Alawiyah, R. (2012). Formulasi tablet ekstrak etanol kulit buah rambutan (Nephelium lappaceum L.) dengan variasi kadar polivynilpyrolidone dan uji aktivitas antioksidan dengan metode DPPH. Skripsi. Universitas Islam Indonesia. Yogyakarta.
34. Voight, R. (1994). Pelajaran Teknologi Farmasi, (Terjemahan), Gadjah Mada University Press, Yogyakarta.
35. Banker, G.S dan Anderson, N.R. (1994). Tablet in the Theory and Practice of Industrial Pharmacy, Ed III, Diterjemahkan Oleh Siti Suyatmi, UI Press. Jakarta.
36. Aslani, A., & Daliri, A. (2016). Design, formulation and evaluation of its physiochemical properties of acetaminophen, ibuprofen and caffeine as effervescent tablet. Journal of Reports in Pharmaceutical Sciences, 5 (2), 122-134.
37. Elisabeth, V et al. (2018). Formulasi sediaan granul dengan bahan pengikat pati kulit pisang goroho (Musa acuminafe L.) dan pengaruhnya pada sifat fisik granul. Jurnal Ilmiah Farmasi-UNSRAT. Vol.7, no.4.
38. Wicjaksono, A.A. (2020). Formulasi dan evaluasi tablet ekstrak temu putih (Curcuma zedoaria (Berg.) Roscoe) Sebagai antibakteri. Skripsi. Universitas Sari Mulia. Banjarmasin.
39. Lynatra, C., Wardiyah., Elisya, Y. (2018). Formulation of effervescent tablet of temulawak extract (Curcuma xanthorrhiza Roxb.) with variation of stevia as sweetener. Jurnal Teknologi dan Seni Kesehatan. Vol. 9, no. 2. 72-82.
40. Gusmayadi, I et al. (2018). Optimasi konsentrasi asam sitrat sebagai sumber asam terhadap waktu larut tablet effervescent ekstrak kering kulit buah manggis (Garcinia mangostana L). Jurnal Ilmiah Ilmu Kefarmasian. Vol.5, no. 1.
41. Khaidir, S et al. (2015). Formulasi tablet ekstrak kangkung air (Ipomoea aquatica F.) dengan variasi kadar amilum manihot sebagai bahan penghancur. Jurnal Ilmiah Farmasi. Vol. 11, no.1.
42. Rori, W. M., et al. (2016). Formulasi dan evaluasi sediaan tablet ekstrak daun gedi hijau (Abelmoschus manihot) dengan metode granulasi basah. Jurnal Ilmiah Farmasi. 5 (2): 243-250.
43. Murtini, G., Yetri E. (2018). Bahan Ajar Farmasi Teknologi Solid. Kementrian Kesehatan Republik Indonesia. Jakarta.
44. Bejugam, N et al. (2015). Tablet formulation of an active pharmaceutical ingredient with a sticking and filming problem:direct compression and dry granulation evaluation. Drug Development Industrial Pharmacy, 41, 333-341.
45. Kartikasari, D.S et al. (2015). Formulasi tablet effervescent ekstrak rimpang jahe emprit (Zingiber officinale Rosc.) dengan variasi kadar asam sitrat dan asam tartrat. Tradisional Medicine Journal, 20 (2).
46. Noval, N., Nugraha, D. F., Nastiti, K., Syahrina, D., & Novia, N. (2021). Local Natural Product Development in the Era of Covid 19 Pandemic. Indonesia Berdaya, 2(2), 133-140.
47. Noval, N., Nastiti, K., Nugraha, D. F., Rahmadani, R., & Alawiyah, T. (2020). PRODUK INOVASI HAND SANITIZER DARI AKAR BAJAKAH SEBAGAI UPAYA PENCEGAHAN DI MASA PANDEMI COVID-19. LOGISTA-Jurnal Ilmiah Pengabdian Kepada Masyarakat, 4(2), 305-312.
48. Hakim A.R. (2019). Formulasi Tablet Efervescen dari Ekstrak Daun Tin (Ficus carica L.) Dengan Kombinasi Asam Sitrat-Asam Tartrat dan Natrium Karbonat. Universitas Islam Indonesia. Yogyakarta.
49. Ainurofiq, A., Azizah, N. (2016). Perbandingan penggunaan bahan penghancur secara intragranular, ekstragranular dan kombinasinya. Journal of Pharmaceutical Science and Clinical Research. 01 (01). Pp 1-9.
50. Apsari, P.A et al. (2018). Formulasi tablet effervescent ekstrak biji melinjo (Gnetum gnemon L.) menggunakan PEG 6000 sebagai lubrikan dan asam sitrat-asam tartrat sebagai sumber asam. Jurnal Ilmu-Ilmu MIPA. Vol. 18.
51. Putri, Y.K & Husni, P. (2018). Artikel tinjaun : pengaruh bahan pengikat terhadap sifat fisik tablet. Farmaka. Vol. 16, no.1.
52. Syamsia., Pratiwi, R.D., & Susana. (2017). Sifat Fisik Tablet Dihiydroartemisinin-Piperaquin (DHP) Sediaan Generik dan Sediaan dengan Nama Dagang yang Beredar di KotaMadya Jayapura. Jurnal Ilmiah Farmasi-UNSRAT, Vol.6 no.3.
53. Yulianti, D.A & Sutoyo, S. (2021). Formulasi tablet effervescent ekstrak daun katuk (Saorupus androgynus L. Merr) dengan variasi konsentrasi asam dan basa. Jurnal Farmasi Sains dan Terapan. Vol.8, no.1.
54. Syukri, Y et al. (2018). Characterization formulation dan evaluation of glibenclamide with B-cyclodextrin inclution complexec tablets. Jurnal Kedokteran dan Kesehatan Indonesia. Vol.9, no. 3.
55. Kumala Sari, L.O.R et al. (2018). Optimasi formula tablet effervescent dispersi padat meloksikam menggunakan desain faktorial. E- Jurnal Pustaka Kesehatan. Vol.6, no.2.
56. Hidayat, I.R., Zuhrotun, A., & Sopyan I. (2021). Design expert software sebagai alat optimasi formulasi sediaan farmasi. Majalah Farmasetika, 6 (1), 99-120.
57. D. Kurniawati, N. Noval, and K. Nastiti, “POTENSI ANTISEPTIK POLIHERBAL DAUN SIRIH (Piper betle), KULIT JERUK NIPIS (Citrus aurantifolia) DAN TANAMAN BUNDUNG (Actinuscirpus grossus) PADA TINDAKAN KEPERAWATAN DAN KEBIDANAN,” Din. Kesehat. J. Kebidanan Dan Keperawatan, vol. 11, no. 1, pp. 420–431, 2020, doi: 10.33859/dksm.v11i1.552.
58. Haryono, I. A., Noval, N., & Nugraha, B. (2021). Formulasi Buah Tampoi (Baccaurea macrocarpa) dalam Sediaan Masker Gel sebagai Antiaging. Jurnal Surya Medika (JSM), 6(2), 102-110. https://doi.org/10.33084/jsm.v6i2.2126.
59. Noval, N., & Raihana, R. (2019). Efek Ekstrak Etanol Akar Pasak Bumi (Eurycoma Longifolia, Jack) terhadap Ekspresi HRAS pada Organ Hati Tikus Galur Sprague Dawley pada Pemberian Doxorubicin. Jurnal Surya Medika (JSM), 5(1), 115-130. https://doi.org/10.33084/jsm.v5i1.952
60. Noorjannah, N., & Noval, N. (2020). Uji Disolusi Terbanding Antara Sediaan Tablet Ramipril Generik Dan Bermerek. Journal of Pharmaceutical Care and Sciences, 1(1), 45-54.
Published
2021-08-30
How to Cite
Syahrina, D., & Noval, N. (2021). Optimasi Kombinasi Asam Sitrat dan Asam Tartrat sebagai Zat Pengasam pada Tablet Effervescent Ekstrak Ubi Jalar Ungu (Ipomoea batatas L). Jurnal Surya Medika (JSM), 7(1), 156-172. https://doi.org/10.33084/jsm.v7i1.2651

Most read articles by the same author(s)

1 2 > >>